Skip to main content
×
Home
    • Aa
    • Aa

Adult cystic hygroma: successful use of OK-432 (Picibanil®)

  • S L Woolley (a1), D R K Smith (a2) and S Quine (a2)
Abstract
AbstractObjective:

We report an adult case of cystic lymphangioma treated with OK-432 (Picibanil®).

Method:

A case report and review of the literature concerning the use of OK-432 to treat cystic lymphangioma is presented.

Results:

A 31-year-old woman developed a cystic lymphangioma four weeks post-partum. This was treated initially by aspiration, for diagnostic purposes. Investigation suggested that surgery would be challenging. A review of the literature demonstrated success with OK-432 in the treatment of this condition, although primarily in the paediatric population. This patient was successfully treated thus, and at the time of writing remained symptom free. A suggested management plan is outlined.

Conclusion:

Treatment with OK-432 is useful in the management of cystic lymphangiomas in adults and should be considered as first line treatment.

Copyright
Corresponding author
Address for correspondence: Dr Sarah L Woolley, Consultant, Emergency Department, Bristol Royal Infirmary, Upper Maudlin Street, Bristol BS2 8BJ, UK. Fax: +44 117 928 2713 E-mail: sarah.woolley@ubht.nhs.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1LT Orvidas , JL Kasperbauer . Pediatric lymphangiomas of the head and neck. Ann Otol Rhinol Laryngol 2000;109:411–21

2BE Sherman , KE Kendall . A unique case of the rapid onset of a large cystic hygroma in the adult. Am J Otolaryngol 2001;22:206–10

3S Ogita , T Tsuto , K Tokiwa , T Takahashi . Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 1987;74:690–1

4S Ogita , T Tsuto , E Deguchi , K Tokiwa , M Nagashima , N Iwai . OK-432 therapy for unresectable lymphangiomas in children. J Ped Surg 1991;26:263–70

5S Ogita , T Tsuto , K Nakamura , E Deguchi , N Iwai . OK-432 therapy in 64 patients with lymphangiomas. J Ped Surg 1994;29:784–5

6JH Greinwald Jr, DK Burke , Y Sato , RI Poust , K Kimura , NM Bauman Treatment of lymphangiomas in children: an update of Picibanil (OK-432) sclerotherapy. Otolaryngol Head Neck Surg 1999;121:381–7

7R Smith , D Burke , Y Sato , RI Poust , K Kimura , NM Bauman . OK-432 therapy for lymphangiomas. Arch Otolaryngol Head Neck Surg 1996;122:1195–9

8CM Giguere , N Bauman , RJH Smith . New treatment options for lymphangioma in infants and children. Ann Otol Rhinol Laryngol 2002;111:1066–75

10JY Sichel , R Udassin , D Gozal , BZ Koplewitz , I Dano , R Eliashar . OK-432 Therapy for cervical lymphangioma. Laryngoscope 2004;114:1805–9

16EJ Ricciardelli , MA Richardson . Cervicofacial cystic hygroma patterns of recurrence and management of the difficult case. Arch Otolaryngol Head Neck Surg 1991;117:546–53

18H Riechelmann , G Muehlfay , T Teck . Total, sub-total, and partial surgical removal of cervicofacial lymphangiomas. Arch Otolaryngol Head Neck Surg 1999;125:643–8

19BJ Hancock , D StVil , M Di Lorenzo , H Blanchard . Complications of lymphangiomas in children. Pediatr Surg 1992;27:220–6

20M Farmaud , JJ Kuttenberger . A new therapeutic concept for the treatment of cystic hygroma. Oral Surg Oral Med Oral Pathol 1996;81:389–95

21M Stein , RK Hsu , PD Schneider , BH Ruebner , Y Mina . Alcohol ablation of a mesenteric lymphangioma. J Vasc Interv Radiol 2000;11:247–50

22J Dubois , L Garel , A Abela , L Laberge , S Yazbeck . Lymphangiomas in children: percutaneous sclerotherapy with an alcoholic solution of Zein. Radiology 1997;204:651–4

25M Castanon , J Margarit , R Carrasco , M Vancells , A Albert , L Morales . Long-term follow up of nineteen cystic lymphangiomas treated with fibrin sealant. J Pediatr Surg 1999;34:1276–9

26MA Reinhardt , SC Nelson , SF Sencer , BC Bostrom , SC Kurachek , ME Nesbit . Treatment of childhood lymphangiomas with interferon-alpha. J Pediatr Hematol Oncol 1997;19:232–6

27JL Villavicencio . Primum non nocere: is it always true? The use of absolute ethanol in the management of congenital vascular malformations. J Vasc Surg 2001;33:904–6

28J Orford , A Barker , S Thonell , P King , J Murphy . Bleomycin therapy for cystic hygroma. J Ped Surg 1995;30:1282–7

31RA Ezekowitz , JB Mulliken , I Folkman . Interferon alfa-2a therapy for life-threatening haemangiomas of infancy. NEJM 1992;326:1456–63

34CM Giguere , N Bauman , Y Sato , DK Burke , JH Greinwald , S Pransky Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial. Arch Otolaryngol Head Neck Surg 2002;128:1137–44

36C Luzzatto , P Midrio , Z Tchaprassian , M Guglielmi . Sclerosing treatment of lymphangiomas with OK-432. Arch Dis Child 2000;82:130–4

37MW Sung , DW Lee , DY Kim , SJ Lee , CH Hwang , SW Park Sclerotherapy with Picibanil (OK-432) for congenital lymphatic malformation in the head and neck. Laryngoscope 2001;111:1430–3

39J Laranne , L Keski-Nisula , R Rautio , M Rautiainen , M Airaksinen . OK-432 (Picibanil) therapy for lymphangiomas in children. Eur Arch Otorhinolaryngol 2002;259:274–8

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: