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The effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinate

  • S Sengul (a1), İ Kaygusuz (a2), M M Akin (a3), Ş Yalcin (a2), T Karlidag (a2), E Keles (a2) and İ Arslan (a4)...

Abstract

Objective:

This study aimed to assess the histopathological effect of OK-432 (Picibanil) on rabbit nasal turbinates.

Methods:

A total of 21 rabbits were divided into 3 treatment groups and various parts of both nasal turbinates were injected with 0.5 ml OK-432, 0.2 ml OK-432 or 0.6 ml saline (control). Bilateral nasal turbinates were later excised and studied under light microscopy to assess any histopathological changes.

Results:

Animals in the 0.2 ml and 0.5 ml OK-432 groups exhibited mild ciliary loss, goblet cell loss and epithelial damage, and a marked increase in inflammatory cell infiltration, submucosal vascularisation and fibrosis. There was a significant difference in histopathological changes between the two OK-432 treated groups. In addition, each OK-432 treated group had significantly more inflammatory cell infiltration, increased submucosal vascularisation and fibrosis compared with controls.

Conclusion:

The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size.

Copyright

Corresponding author

Address for correspondence: Prof. İ Kaygusuz, Department of Otorhinolaryngology, Firat UniversityMedical Faculty, 23200 Elazig, Turkey Fax: +90 424 238 80 96 E-mail: kaygusuz_67@yahoo.com

Footnotes

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Presented as an oral poster at the 36th Turkish National Otorhinolaryngology Head and Neck Surgery Congress, 5–9 November, 2014. Antalya, Turkey

Footnotes

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