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The effects of D and L Isomers of menthol upon nasal sensation of airflow

  • R. Eccles (a1), D. H. Griffiths (a1), C. G. Newton (a1) and N. S. Tolley (a1)


Objective and subjective measurements of nasal airflow were made before and after inhalation of Vanilla, D-Menthol and L-Menthol separately. Despite the fact that the menthol isomers were mirror images of one another, only L-Menthol produced the sensation of increased nasal airway patency. No objective change in resistance was found after inhaling either D-Menthol, L-Menthol or the vanilla control. These findings demonstrate that L-Menthol exerts a specific action upon nasal sensory nerve endings, which are responsible for the subjective appreciation of nasal airflow.


Corresponding author

R. Eccles, Senior Lecturer in Physiology, University College Cardiff, University College, P O Box 78, Cardiff CF1 1XL.


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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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