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The effects of D and L Isomers of menthol upon nasal sensation of airflow

  • R. Eccles (a1), D. H. Griffiths (a1), C. G. Newton (a1) and N. S. Tolley (a1)

Abstract

Objective and subjective measurements of nasal airflow were made before and after inhalation of Vanilla, D-Menthol and L-Menthol separately. Despite the fact that the menthol isomers were mirror images of one another, only L-Menthol produced the sensation of increased nasal airway patency. No objective change in resistance was found after inhaling either D-Menthol, L-Menthol or the vanilla control. These findings demonstrate that L-Menthol exerts a specific action upon nasal sensory nerve endings, which are responsible for the subjective appreciation of nasal airflow.

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Corresponding author

R. Eccles, Senior Lecturer in Physiology, University College Cardiff, University College, P O Box 78, Cardiff CF1 1XL.

References

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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