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Eosinophilic oesophagitis: a systematic review for otolaryngologists

  • M Bahgat (a1), N Dawe (a1) and L Flood (a1)

Abstract

Background:

Eosinophilic oesophagitis is a chronic, immune/antigen-mediated oesophageal disease, only recently, but increasingly, recognised in the world literature. It is diagnosed and managed primarily by medical gastroenterologists and allergy specialists, and is a distinct disease entity, affecting both children and adults. Few studies have been published in otolaryngology journals, although otolaryngologists will encounter patients with undiagnosed eosinophilic oesophagitis. Patients may present with dysphagia, bolus obstruction or with other ENT disorders, such as atopic rhinitis, reflecting the underlying systemic allergic disorder.

Objective:

This paper systematically reviews the evidence base published on the epidemiology, clinical presentation, diagnosis, treatment and prognosis of eosinophilic oesophagitis, particularly as it relates to otolaryngology practice.

Copyright

Corresponding author

Address for correspondence: Mr Liam Flood, Department of ENT, James Cook University Hospital, Middlesbrough TS4 3BW, UK E-mail: liam.flood@nhs.net

References

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1Furuta, GT, Liacouras, CA, Collins, MH, Gupta, SK, Justinich, C, Putnam, PE et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007;133:1342–63
2Liacouras, CA, Furuta, GT, Hirano, I, Atkins, D, Attwood, SE, Bonis, PA et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol 2011;128:320
3Dellon, ES, Gonsalves, N, Hirano, I, Furuta, GT, Liacouras, CA, Katzka, DA. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol 2013;108:679–92
4Winter, HS, Madara, JL, Stafford, RJ, Grand, RJ, Quinlan, JE, Goldman, H. Intraepithelial eosinophils: a new diagnostic criterion for reflux esophagitis. Gastroenterology 1982;83:818–23
5Attwood, SE, Smyrk, T, Demeester, T, Jones, J. Esophageal eosinophilia with dysphagia. Dig Dis Sci 1993;38:109–16
6Kelly, KJ, Lazenby, AJ, Rowe, PC, Yardley, JH, Perman, JA, Sampson, HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology 1995;109:1503–12
7Prasad, GA, Alexander, JA, Schleck, CD, Zinsmeister, AR, Smyrk, TC, Elias, RM et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol 2009;7:1055–61
8Hruz, P, Straumann, A, Bussman, C, Heer, P, Simon, H-U, Zwahlen, M et al. Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J Allergy Clin Immunol 2011;128:1349–50
9Ngiu, CS, Low, SF. Meta-analysis and systematic review of prevalence of eosinophilic esophagitis in Asia. J Gastroenterol Hepatol 2012;27:325
10Cherian, S, Smith, NM, Forbes, DA. Rapidly increasing prevalence of eosinophilic oesophagitis in Western Australia. Arch Dis Child 2006;91:1000–4
11DeBrosse, CW, Collins, MH, Buckmeier, BB, Allen, CL, King, EC, Assa'ad, AH et al. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982–1999. J Allergy Clin Immunol 2010;126:112–19
12Sealock, RJ, Rendon, G, El-Serag, HB. Systematic review: the epidemiology of eosinophilic oesophagitis in adults. Aliment Pharmacol Ther 2010;32:712–19
13Dellon, ES, Jensen, ET, Martin, CF, Shaheen, NJ, Kappelman, MD. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol 2014;12:589–96
14Soon, IS, Butzner, JD, Kaplan, GG, Debruyn, JC. Incidence and prevalence of eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr 2013;57:7280
15Simon, D, Marti, H, Heer, P, Simon, H-U, Braathen, LR, Straumann, A. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol 2005;115:1090–2
16Assa'ad, A. Eosinophilic esophagitis: association with allergic disorders. Gastrointest Endosc Clin N Am 2008;18:119–32
17Karkos, PD, Srivastava, R, Kaptanis, S, Vaughan, C. Eosinophilic esophagitis for the otolaryngologist. Int J Otolaryngol 2012;2012:181402
18Dauer, EH, Ponikau, JU, Smyrk, TC, Murray, JA, Thompson, DM. Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging association. Ann Otol Rhinol Laryngol 2006;115:507–17
19Kelly, EA, Linn, D, Keppel, KL, Noel, RJ, Chun, RH. Otolaryngologic surgeries are frequent in children with eosinophilic esophagitis. Ann Otol Rhinol Laryngol 2014;124:355–60
20Smith, LP, Chewaproug, L, Spergel, JM, Zur, KB. Otolaryngologists may not be doing enough to diagnose pediatric eosinophilic esophagitis. Int J Pediatr Otorhinolaryngol 2009;73:1554–7
21Elliott, EJ, Thomas, D, Markowitz, JE. Non-surgical interventions for eosinophilic esophagitis. Cochrane Database Syst Rev 2010;(3):CD004065
22Kim, HP, Vance, RB, Shaheen, NJ, Dellon, ES. The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. Clin Gastroenterol Hepatol 2012;10:988–96
23Arias, A, Gonzalez-Cervera, J, Tenias, JM, Lucendo, AJ. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology 2014;146:1639–48
24Lucendo, AJ, Arias, A, Tenias, JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014;113:624–9
25Moawad, FJ, Cheatham, JG, Dezee, KJ. Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis. Aliment Pharmacol Ther 2013;38:713–20
26Kavitt, RT, Penson, DF, Vaezi, MF. Eosinophilic esophagitis: dilate or medicate? A cost analysis model of the choice of initial therapy. Dis Esophagus 2014;27:418–23
27Lin, SK, Sabharwal, G, Ghaffari, G. A review of the evidence linking eosinophilic esophagitis and food allergy. Allergy Asthma Proc 2015;36:2633
28Sgouros, SN, Bergele, C, Mantides, A. Eosinophilic esophagitis in adults: what is the clinical significance? Endoscopy 2006;38:515–20
29Molina-Infante, J, Katzka, DA, Gisbert, JP. Review article: proton pump inhibitor therapy for suspected eosinophilic oesophagitis. Aliment Pharmacol Ther 2013;37:1157–64
30Chuang, MY, Chinnaratha, MA, Hancock, DG, Woodman, R, Wong, GR, Cock, C et al. Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): a systematic review and meta-analysis. Clin Transl Gastroenterol 2015;6:e82
31Bohm, ME, Richter, JE. Review article: oesophageal dilation in adults with eosinophilic oesophagitis. Aliment Pharmacol Ther 2011;33:748–57
32Bergquist, H, Bove, M. Eosinophilic esophagitis in adults: an ear, nose, and throat perspective. Laryngoscope 2009;119:1467–71
33Liacouras, CA, Markowitz, JE. Eosinophilic esophagitis: a subset of eosinophilic gastroenteritis. Curr Gastroenterol Rep 1999;1:253–8
34Dellon, ES. Do you see what I see? Towards standardized reporting of endoscopic findings in eosinophilic esophagitis. Endoscopy 2014;46:1043–5
35Collins, MH. Histopathologic features of eosinophilic esophagitis. Gastrointest Endosc Clin N Am 2008;18:5971
36Dellon, ES. Eosinophilic esophagitis: diagnostic tests and criteria. Curr Opin Gastroenterol 2012;28:382–8
37Spechler, SJ, Genta, RM, Souza, RF. Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol 2007;102:1301–6
38Kia, L, Hirano, I. Distinguishing GERD from eosinophilic oesophagitis: concepts and controversies. Nat Rev Gastroenterol Hepatol 2015;12:379–86
39Doerfler, B, Bryce, P, Hirano, I, Gonsalves, N. Practical approach to implementing dietary therapy in adults with eosinophilic esophagitis: the Chicago experience. Dis Esophagus 2015;28:4258
40Amin, MR, Postma, GN, Setzen, M, Koufman, JA. Transnasal esophagoscopy: a position statement from the American Bronchoesophagological Association (ABEA). Otolaryngol Head Neck Surg 2008;138:411–14
41Attwood, SE, Furuta, GT. Eosinophilic esophagitis: historical perspective on an evolving disease. Gastroenterol Clin North Am 2014;43:185–99
42Attwood, S, Sabri, S. Historical aspects of eosinophilic esophagitis: from case reports to clinical trials. Dig Dis 2014;32:34–9
43Helou, EF, Simonson, J, Arora, AS. 3-yr-follow-up of topical corticosteroid treatment for eosinophilic esophagitis in adults. Am J Gastroenterol 2008;103:2194–9
44Konikoff, MR, Noel, RJ, Blanchard, C, Kirby, C, Jameson, SC, Buckmeier, BK et al. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology 2006;131:1381–91
45Alexander, JA, Jung, KW, Arora, AS, Enders, F, Katzka, DA, Kephardt, GM et al. Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2012;10:742–9
46Butz, BK, Wen, T, Gleich, GJ, Furuta, GT, Spergel, J, King, E et al. Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology 2014;147:324–33
47Schaefer, ET, Fitzgerald, JF, Molleston, JP, Croffie, JM, Pfefferkorn, MD, Corkins, MR et al. Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children. Clin Gastroenterol Hepatol 2008;6:165–73
48Dohil, R, Newbury, R, Fox, L, Bastian, J, Aceves, S. Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial. Gastroenterology 2010;139:418–29
49Gupta, SK, Vitanza, JM, Collins, MH. Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2015;13:6676
50Straumann, A, Conus, S, Degen, L, Felder, S, Kummer, M, Engel, H et al. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology 2010;139:1526–37
51Straumann, A, Conus, S, Degen, L, Frei, C, Bussmann, C, Beglinger, C et al. Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol 2011;9:400–9
52Assa'ad, AH, Gupta, SK, Collins, MH, Thomson, M, Heath, AT, Smith, DA et al. An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 2011;141:1593–604
53Straumann, A, Conus, S, Kita, H, Kephart, G, Bussmann, C, Beglinger, C et al. Mepolizumab, a humanized monoclonal antibody to IL-5, for severe eosinophilic esophagitis in adults: a randomized, placebo-controlled double-blind trial. Gastroenterology 2007;132:2586
54Kottyan, LC, Davis, BP, Sherrill, JD, Liu, K, Rochman, M, Kaufman, K et al. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet 2014;46:895900
55Alexander, ES, Martin, LJ, Collins, MH, Kottyan, LC, Sucharew, H, He, H et al. Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol 2014;134:1084–92
56Blanchard, C, Wang, N, Stringer, KF, Mishra, A, Fulkerson, PC, Abonia, JP et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest 2006;116:536–47
57Hirano, I, Moy, N, Heckman, MG, Thomas, CS, Gonsalves, N, Achem, SR. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut 2013;62:489–95
58Tanaka, K, Rubio, CA, Dlugosz, A, Truskaite, K, Befrits, R, Lindberg, G et al. Narrow-band imaging magnifying endoscopy in adult patients with eosinophilic esophagitis/esophageal eosinophilia and lymphocytic esophagitis. Gastrointest Endosc 2013;78:659–64
59Van Rhijn, BD, Warners, MJ, Curvers, WL, Van Lent, AU, Bekkali, NL, Takkenberg, RB et al. Evaluating the Endoscopic Reference Score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability. Endoscopy 2014;46:1049–55
60Brigger, MT, Misdraji, J, Hardy, SC, Hartnick, CJ. Eosinophilic esophagitis in children: a pathologic or clinicopathologic diagnosis? Arch Otolaryngol Head Neck Surg 2009;135:95100
61Dellon, ES, Speck, O, Woodward, K, Gebhart, JH, Madanick, RD, Levinson, S et al. Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study. Am J Gastroenterol 2013;108:1854–60
62Dellon, ES, Speck, O, Woodward, K, Covey, S, Rusin, S, Gebhart, JH et al. Markers of eosinophilic inflammation for diagnosis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia: a prospective study. Clin Gastroenterol Hepatol 2014;12:2015–22
63Lewis, CJ, Lamb, CA, Kanakala, V, Pritchard, S, Armstrong, GR, Attwood, SE. Is the etiology of eosinophilic esophagitis in adults a response to allergy or reflux injury? Study of cellular proliferation markers. Dis Esophagus 2009;22:249–55
64Molina-Infante, J, Hernandez-Alonso, M, Vinagre-Rodriguez, G, Mateos-Rodriguez, JM, Duenas-Sadornil, C, Perez-Gallardo, B et al. Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression. Aliment Pharmacol Ther 2014;40:955–65
65Liacouras, CA, Wenner, WJ, Brown, K, Ruchelli, E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr 1998;26:380–5
66Lopez-Lazaro, L, Marx, C, Bussmann, C, Straumann, A. Active eosinophilic esophagitis is associated with impaired elimination of budesonide by cytochrome P450 3A enzymes. Digestion 2013;87:110–17
67Garrett, JK, Jameson, SC, Thomson, B, Collins, MH, Wagoner, LE, Freese, DK et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol 2004;113:115–19
68Schoepfer, AM, Panczak, R, Zwahlen, M, Kuehni, CE, Coslovsky, M, Maurer, E et al. How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients? Am J Gastroenterol 2015;110:402–14
69Liacouras, CA, Spergel, JM, Ruchelli, E, Verma, R, Mascarenhas, M, Semeao, E et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol 2005;3:1198–206
70Noel, RJ, Putnam, PE, Rothenberg, ME. Eosinophilic esophagitis. N Engl J Med 2004;351:940–1
71Spergel, JM, Brown-Whitehorn, TF, Beausoleil, JL, Franciosi, J, Shuker, M, Verma, R et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 2009;48:30–6
72Lee, RG. Marked eosinophilia in esophageal mucosal biopsies. Am J Surg Pathol 1985;9:475–9
73Rothenberg, ME, Spergel, JM, Sherrill, JD, Annaiah, K, Martin, LJ, Cianferoni, A et al. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet 2010;42:289–91
74Assa'ad, AH, Putnam, PE, Collins, MH, Akers, RM, Jameson, SC, Kirby, CL et al. Pediatric patients with eosinophilic esophagitis: an 8-year follow-up. J Allergy Clin Immunol 2007;119:731–8
75Abonia, JP, Wen, T, Stucke, EM, Grotjan, T, Griffith, MS, Kemme, KA et al. High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders. J Allergy Clin Immunol 2013;132:378–86
76Straumann, A, Spichtin, H-P, Grize, L, Bucher, KA, Beglinger, C, Simon, H-U. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology 2003;125:1660–9
77Sperry, SL, Crockett, SD, Miller, CB, Shaheen, NJ, Dellon, ES. Esophageal foreign-body impactions: epidemiology, time trends, and the impact of the increasing prevalence of eosinophilic esophagitis. Gastrointest Endosc 2011;74:985–91
78Ricker, J, McNear, S, Cassidy, T, Plott, E, Arnold, H, Kendall, B et al. Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Therap Adv Gastroenterol 2011;4:2735
79Prasad, GA, Talley, NJ, Romero, Y, Arora, AS, Kryzer, LA, Smyrk, TC et al. Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study. Am J Gastroenterol 2007;102:2627–32
80Veerappan, GR, Perry, JL, Duncan, TJ, Baker, TP, Maydonovitch, C, Lake, JM et al. Prevalence of eosinophilic esophagitis in an adult population undergoing upper endoscopy: a prospective study. Clin Gastroenterol Hepatol 2009;7:420–6
81Dellon, ES, Kim, HP, Sperry, SL, Rybnicek, DA, Woosley, JT, Shaheen, NJ. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc 2014;79:577–85
82Schoepfer, AM, Safroneeva, E, Bussmann, C, Kuchen, T, Portmann, S, Simon, H-U et al. Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology 2013;145:1230–6
83Lee, J, Huprich, J, Kujath, C, Ravi, K, Enders, F, Smyrk, TC et al. Esophageal diameter is decreased in some patients with eosinophilic esophagitis and might increase with topical corticosteroid therapy. Clin Gastroenterol Hepatol 2012;10:481–6
84Hori, K, Watari, J, Fukui, H, Tanaka, J, Tomita, T, Sakurai, J et al. Do endoscopic features suggesting eosinophilic esophagitis represent histological eosinophilia? Dig Endosc 2014;26:156–63
85Rodrigo, S, Abboud, G, Oh, D, DeMeester, SR, Hagen, J, Lipham, J et al. High intraepithelial eosinophil counts in esophageal squamous epithelium are not specific for eosinophilic esophagitis in adults. Am J Gastroenterol 2008;103:435–42
86Abe, Y, Iijima, K, Ohara, S, Koike, T, Kikuchi, R, Kato, K et al. Localized esophageal eosinophilia: is it an early manifestation of eosinophilic esophagitis or a subtype of gastroesophageal reflux disease? Dig Endosc 2014;26:337–43
87Nielsen, JA, Lager, DJ, Lewin, M, Rendon, G, Roberts, CA. The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinophilic esophagitis. Am J Gastroenterol 2014;109:515–20
88Bove, M, Tegtmeyer, B, Persson, S, Bergquist, H. The pharyngeal mucosa is not involved in eosinophilic oesophagitis. Aliment Pharmacol Ther 2009;30:495500
89Ravi, K, Katzka, DA, Smyrk, TC, Prasad, GA, Romero, Y, Francis, DL et al. Prevalence of esophageal eosinophils in patients with Barrett's esophagus. Am J Gastroenterol 2011;106:851–7
90Mueller, S, Neureiter, D, Aigner, T, Stolte, M. Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material. Histopathology 2008;53:676–84
91Dranove, JE, Horn, DS, Davis, MA, Kernek, KM, Gupta, SK. Predictors of response to proton pump inhibitor therapy among children with significant esophageal eosinophilia. J Pediatr 2009;154:96100
92Arora, AS, Perrault, J, Smyrk, TC. Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults. Mayo Clin Proc 2003;78:830–5
93Faubion, JW, Perrault, J, Burgart, LJ, Zein, NN, Clawson, M, Freese, DK. Treatment of eosinophilic esophagitis with inhaled corticosteroids. J Pediatr Gastroenterol Nutr 1998;27:90–3
94Kuchen, T, Straumann, A, Safroneeva, E, Romero, Y, Bussmann, C, Vavricka, S et al. Swallowed topical corticosteroids reduce the risk for long-lasting bolus impactions in eosinophilic esophagitis. Allergy 2014;69:1248–54
95Bergquist, H, Larsson, H, Johansson, L, Bove, M. Dysphagia and quality of life may improve with mometasone treatment in patients with eosinophilic esophagitis: a pilot study. Otolaryngol Head Neck Surg 2011;145:551–6
96Attwood, SE, Lewis, CJ, Bronder, CS, Morris, CD, Armstrong, GR, Whittam, J. Eosinophilic oesophagitis: a novel treatment using Montelukast. Gut 2003;52:181–5
97Kaplan, M, Mutlu, EA, Jakate, S, Bruninga, K, Losurdo, J, Losurdo, J et al. Endoscopy in eosinophilic esophagitis: “feline” esophagus and perforation risk. Clin Gastroenterol Hepatol 2003;1:433–7
98Cohen, MS, Kaufman, AB, Palazzo, JP, Nevin, D, Dimarino, AJ, Cohen, S. An audit of endoscopic complications in adult eosinophilic esophagitis. Clin Gastroenterol Hepatol 2007;5:1149–53
99Schoepfer, AM, Gonsalves, N, Bussmann, C, Conus, S, Simon, H-U, Straumann, A et al. Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation. Am J Gastroenterol 2010;105:1062–70
100Croese, J, Fairley, SK, Masson, JW, Chong, AK, Whitaker, DA, Kanowski, PA et al. Clinical and endoscopic features of eosinophilic esophagitis in adults. Gastrointest Endosc 2003;58:516–22
101Ally, MR, Dias, J, Veerappan, GR, Maydonovitch, CL, Wong, RK, Moawad, FJ. Safety of dilation in adults with eosinophilic esophagitis. Dis Esophagus 2013;26:241–5
102Orenstein, SR, Shalaby, TM, Di Lorenzo, C, Putnam, PE, Sigurdsson, L, Mousa, H et al. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol 2000;95:1422–30
103Dauer, EH, Freese, DK, El-Youssef, M, Thompson, DM. Clinical characteristics of eosinophilic esophagitis in children. Ann Otol Rhinol Laryngol 2005;114:827–33
104Hill, CA, Ramakrishna, J, Fracchia, MS, Sternberg, D, Ojha, S, Infusino, S et al. Prevalence of eosinophilic esophagitis in children with refractory aerodigestive symptoms. JAMA Otolaryngol Head Neck Surg 2013;139:903–6
105Duval, M, Tarasidis, G, Grimmer, JF, Muntz, HR, Park, AH, Smith, M et al. Role of operative airway evaluation in children with recurrent croup: a retrospective cohort study. Clin Otolaryngol 2015;40:227–33
106Cooper, T, Kuruvilla, G, Persad, R, El-Hakim, H. Atypical croup: association with airway lesions, atopy, and esophagitis. Otolaryngol Head Neck Surg 2012;147:209–14
107Paddack, A, Gibbons, T, Smith, C, Patil, S, Richter, GT. Food hypersensitivity and otolaryngologic conditions in young children. Otolaryngol Head Neck Surg 2012;147:215–20
108Otteson, TD, Mantle, BA, Casselbrant, ML, Goyal, A. The otolaryngologic manifestations in children with eosinophilic esophagitis. Int J Pediatr Otorhinolaryngol 2012;76:116–19
109Greifer, M, Santiago, MT, Tsirilakis, K, Cheng, JC, Smith, LP. Pediatric patients with chronic cough and recurrent croup: the case for a multidisciplinary approach. Int J Pediatr Otorhinolaryngol 2015;79:749–52
110Yawn, RJ, Acra, S, Goudy, SL, Flores, R, Wootten, CT. Eosinophilic laryngitis in children with aerodigestive dysfunction. Otolaryngol Head Neck Surg 2015;153:124–9
111Williams, P, Jameson, S, Bishop, P, Sawaya, D, Nowicki, M. Esophageal foreign bodies and eosinophilic esophagitis - the need for esophageal mucosal biopsy: a 12-year survey across pediatric subspecialties. Surg Endosc 2013;27:2216–20
112Hudson, S, Sampson, C, Muntz, HR, Jackson, WD, Smith, ME. Foreign body impaction as presentation of eosinophilic esophagitis. Otolaryngol Head Neck Surg 2013;149:679–81
113Bennett, AM, Sharma, A, Price, T, Montgomery, PQ. The management of foreign bodies in the pharynx and oesophagus using transnasal flexible laryngo-oesophagoscopy (TNFLO). Ann R Coll Surg Engl 2008;90:1316
114Lucendo, AJ, Arias, T, Molina-Infante, J, Rodriguez-Sanchez, J, Rodrigo, L, Nantes, T et al. Diagnostic and therapeutic management of eosinophilic oesophagitis in children and adults: results from a Spanish registry of clinical practice. Dig Liver Dis 2013;45:562–8
115Butsch Kovacic, M, Biagini Myers, JM, Lindsey, M, Patterson, T, Sauter, S, Ericksen, MB et al. The Greater Cincinnati Pediatric Clinic Repository: a novel framework for childhood asthma and allergy research. Pediatr Allergy Immunol Pulmonol 2012;25:104–13
116Hommel, KA, DeBrosse, CW, Greenberg, AB, Greenler, AJ, Abonia, JP, Rothenberg, ME et al. Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. BMC Gastroenterol 2011;11:126
117Hartnick, CJ, Liu, JH, Cotton, RT, Rudolph, C. Subglottic stenosis complicated by allergic esophagitis: case report. Ann Otol Rhinol Laryngol 2002;111:5760
118Sharaf, RN, Shergill, AK, Odze, RD, Krinsky, ML, Fukami, N, Jain, R et al. Endoscopic mucosal tissue sampling. Gastrointest Endosc 2013;78:216–24
119Sperry, SL, Shaheen, NJ, Dellon, ES. Effect of guidelines for eosinophilic esophagitis on variability of diagnostic criteria in the medical literature. Gastroenterology 2011;140:S2401
120Dellon, ES, Speck, O, Woodward, K, Woosley, JT, Shaheen, NJ. The patchy nature of esophageal eosinophilia in eosinophilic esophagitis: insights from pathology samples from a clinical trial. Gastroenterology 2012;142:S432
121Gonsalves, N, Doerfler, B, Schwartz, S, Yang, G-Y, Zalewski, A, Amsden, K et al. Prospective trial of four food elimination diet demonstrates comparable effectiveness in the treatment of adult and pediatric eosinophilic esophagitis. Gastroenterology 2013;144:S154
122Khanna, S, Kujath, C, Katzka, D, Arora, A, Grothe, R, Romero, Y et al. The natural history of symptomatic esophageal eosinophilia: a longitudinal follow-up over 5 years. Am J Gastroenterol 2011;106:S19
123Gonsalves, N, Policarpio-Nicolas, M, Zhang, Q, Rao, MS, Hirano, I. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc 2006;64:313–19
124Attwood, SE, Lamb, CA. Eosinophilic oesophagitis and other non-reflux inflammatory conditions of the oesophagus: diagnostic imaging and management. Best Pract Res Clin Gastroenterol 2008;22:639–60
125United European Gastroenterology. Harmonizing diagnosis and therapy of Eosinophilic Oesophagitis (EoE) across Europe (HaEoE-EU). In: https://www.ueg.eu/fileadmin/user_upload/documents/Awards/HaEoE_EU_ProjectDescription_LinkAward_2014.pdf [18 September 2015]
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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