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Gender and laterality in semicircular canal dehiscence syndrome

  • K Karimnejad (a1), M S Czerny (a2), S Lookabaugh (a3), D J Lee (a4) and A A Mikulec (a1)...

To determine if there is gender or laterality predilection in patients with semicircular canal dehiscence syndrome.


A multi-institutional chart review was performed to identify patients diagnosed with semicircular canal dehiscence between 2000 and 2015. A systematic literature search was conducted using PubMed to further identify patients with semicircular canal dehiscence. Age, gender and laterality data were collected. Statistical analysis was performed to evaluate for gender or laterality preponderance.


A total of 682 patients with semicircular canal dehiscence were identified by literature and chart review. Mean age of diagnosis was 49.75 years (standard deviation = 15.33). Semicircular canal dehiscence was associated with a statistically significant female predominance (chi-square = 7.185, p = 0.007); the female-to-male ratio was 1.2 to 1. Left-sided semicircular canal dehiscence was most common, followed by right-sided then bilateral (chi-square = 23.457, p < 0.001).


Semicircular canal dehiscence syndrome is most commonly left-sided and exhibits a female predominance. This may be secondary to morphological cerebral hemisphere asymmetries in both sexes and a predilection of women to seek more medical care than men.

Corresponding author
Address for correspondence: Dr Anthony A Mikulec, Department of Otolaryngology – Head and Neck Surgery, Saint Louis University School of Medicine, 3635 Vista Avenue, 6FDT, St Louis, MO 63110, USA Fax: +1 314 268 5111 E-mail:
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