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Genetics of otosclerosis

  • R. Sabitha (a1), Ravi Ramalingam (a2), K. K. Ramalingam (a2), T. A. Sivakumaran (a1) and A. Ramesh (a1)
  • DOI: http://dx.doi.org/10.1017/S0022215100136606
  • Published online: 01 June 2007
Abstract
Abstract

Otosclerosis is an early-middle adult life genetic disease affecting bone remodelling in the ear. Current knowledge of otosclerosis as an inherited disease dates to the mid-19th century, and we report here an attempt to understand the genetics of otosclerosis and detect its heterogeneity. The analysis was conducted on 151 otosclerotic families. The results of our study indicate that while heredity plays an important role in the manifestation of the disease a substantial portion of otosclerotic cases could arise due to non-genetic causes.

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Corresponding author
Address for correspondence: Dr A. Ramesh, Department of GeneticsDr ALMPGIBMS, Taramani, Madras 600 113, India. Fax: 91-044-4926709
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This work was presented at the Seminar on Genetic Epidemiology and XX Annual Conference of Indian Society of Human Genetics held December 11–13, 1994, at the Department of Genetics, Osmania University, Hyderabad – 7.

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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

W. H. James (1989) Sex ratios in otosclerotic families. Journal of Laryngology and Otology 103: 10361039.

W. H. James (1991) Sex ratios of probands and secondary cases in conditions of multifactorial inheritance where liability varies with sex. Journal of Medical Genetics 28: 4143.

J. R. McPhee , M. A. Gordon , R. J. Ruben , T. R. Van de Water (1993) Evidence of abnormal stromelysin mRNA expression in suspected carriers of otosclerosis. Archives of Otolaryngology, Head and Neck Surgery 119: 11081116.

R. Raman , J. Mathews , J. Idikula (1991) Obliterative otosclerosis. Journal of Laryngology and Otology 105: 899900.

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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