Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 7
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Thys, Melissa and Camp, Guy Van 2009. Genetics of Otosclerosis. Otology & Neurotology, Vol. 30, Issue. 8, p. 1021.

    Yutaka Imauchi, Xavier Jeunemaître, Magali Boussion, Evelyne Ferrary, Olivier Sterkers, and Alexis Bozorg Grayeli, 2008. Relation Between Renin-Angiotensin-Aldosterone System and Otosclerosis. Otology & Neurotology, Vol. 29, Issue. 3, p. 295.

    Moumoulidis, I. Axon, P. Baguley, D. and Reid, E. 2007. A review on the genetics of otosclerosis. Clinical Otolaryngology, Vol. 32, Issue. 4, p. 239.

    Casellini, Carolina Citera, Gustavo Rosemffet, Marcos Ruggeri, Santiago Saviotti, Andrea and Cocco, Jos?? A. Maldonado 2005. Audiovestibular Disorders in Patients With Ankylosing Spondylitis. JCR: Journal of Clinical Rheumatology, Vol. 11, Issue. 2, p. 81.

    Grayeli, Alexis Bozorg Escoubet, Brigitte Bichara, Maurice Julien, Nicolas Silve, Caroline Friedlander, Gérard Sterkers, Olivier and Ferrary, Evelyne 2003. Increased Activity of the Diastrophic Dysplasia Sulfate Transporter in Otosclerosis and Its Inhibition by Sodium Fluoride. Otology & Neurotology, Vol. 24, Issue. 6, p. 854.

    Morín Murillo, G.L. Jáuregui Renaud, K. Zepeda López, E.G. del Castillo Mendoza, S. and Bello Mora, A. 2002. Estabilidad de los umbrales de audición durante las primeras 5 semanas post-estapedectomía. Acta Otorrinolaringológica Española, Vol. 53, Issue. 5, p. 321.

    Shin, Young Je Calvas, Patrick Deguine, Olivier Charlet, Jean-Paul Cognard, Christophe and Fraysse, Bernard 2001. Correlations Between Computed Tomography Findings and Family History in Otosclerotic Patients. Otology & Neurotology, Vol. 22, Issue. 4, p. 461.


Genetics of otosclerosis

  • R. Sabitha (a1), Ravi Ramalingam (a2), K. K. Ramalingam (a2), T. A. Sivakumaran (a1) and A. Ramesh (a1)
  • DOI:
  • Published online: 01 June 2007

Otosclerosis is an early-middle adult life genetic disease affecting bone remodelling in the ear. Current knowledge of otosclerosis as an inherited disease dates to the mid-19th century, and we report here an attempt to understand the genetics of otosclerosis and detect its heterogeneity. The analysis was conducted on 151 otosclerotic families. The results of our study indicate that while heredity plays an important role in the manifestation of the disease a substantial portion of otosclerotic cases could arise due to non-genetic causes.

Corresponding author
Address for correspondence: Dr A. Ramesh, Department of GeneticsDr ALMPGIBMS, Taramani, Madras 600 113, India. Fax: 91-044-4926709
Hide All

This work was presented at the Seminar on Genetic Epidemiology and XX Annual Conference of Indian Society of Human Genetics held December 11–13, 1994, at the Department of Genetics, Osmania University, Hyderabad – 7.

Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

W. H. James (1989) Sex ratios in otosclerotic families. Journal of Laryngology and Otology 103: 10361039.

W. H. James (1991) Sex ratios of probands and secondary cases in conditions of multifactorial inheritance where liability varies with sex. Journal of Medical Genetics 28: 4143.

J. R. McPhee , M. A. Gordon , R. J. Ruben , T. R. Van de Water (1993) Evidence of abnormal stromelysin mRNA expression in suspected carriers of otosclerosis. Archives of Otolaryngology, Head and Neck Surgery 119: 11081116.

R. Raman , J. Mathews , J. Idikula (1991) Obliterative otosclerosis. Journal of Laryngology and Otology 105: 899900.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *