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Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer

  • J R Qualliotine (a1) (a2), J A Califano (a1) (a2) (a3), R J Li (a1) (a4), D Gold (a3), B Messing (a3), G Lee (a3), P Ha (a1) (a3) (a5) and C Fakhry (a1) (a3)...
Abstract Background:

Several risk factors for depression in patients with oropharyngeal cancer have been determined. However, it is unknown whether human papillomavirus associated oropharyngeal cancer, which has a distinct clinico-demographic profile, modulates this risk.


A retrospective analysis was conducted of patients with oropharyngeal cancer. These patients had completed a 10-item depression screening questionnaire before receiving treatment for their disease from 2011 to 2014. Associations between patient or disease characteristics and depression screening questionnaire results were investigated.


The study comprised 69 patients, 31 (44.9 per cent) of whom screened positive for depression. There were no significant differences in distributions of clinico-demographic or histopathological characteristics, including human papillomavirus tumour status, by depression screen result.


This population has a high risk for depression, but no obvious risk factors, including human papillomavirus tumour status, were associated with an elevated risk. This inability to risk-stratify patients by clinico-demographic or disease characteristics emphasises the importance of regular depression screening for all patients in this population.

Corresponding author
Address for correspondence: Dr Carole Fakhry, Department of Otolaryngology – Head and Neck Surgery, 601 N Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA Fax: +01 (410) 955 6526 E-mail:
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1 P Waraich , EM Goldner , J Somers , L Hsu . Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry 2004;49:124–38

2 AM Krebber , LM Buffart , G Kleijn , IC Riepma , R De Bree , CR Leemans Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology 2014;23:121–30

4 A Kugaya , T Akechi , T Okuyama , T Nakano , I Mikami , H Okamura Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer. Cancer 2000;88:2817–23

5 B Barber , J Dergousoff , M Nesbitt , N Mitchell , J Harris , D O'Connell Depression as a predictor of postoperative functional performance status (PFPS) and treatment adherence in head and neck cancer patients: a prospective study. J Otolaryngol Head Neck Surg 2015;44:38

6 S-A Kim , J-L Roh , S-A Lee , S Lee , S-B Kim , S-H Choi Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer. Cancer 2016;122:131–40

7 E Hammerlid , E Silander , L Hörnestam , M Sullivan . Health-related quality of life three years after diagnosis of head and neck cancer--a longitudinal study. Head Neck 2001;23:113–25

8 RC Hall , MG Wise . The clinical and financial burden of mood disorders. Cost and outcome. Psychosomatics 1995;36:S1118

9 D Beck , H Koenig . Minor depression: a review of the literature. Int J Psychiatry Med 1996;26:177209

10 GP Yu , V Mehta , D Branovan , Q Huang , S Schantz . Non-cancer-related deaths from suicide, cardiovascular disease, and pneumonia in patients with oral cavity and oropharyngeal squamous carcinoma. Arch Otolaryngol Head Neck Surg 2012;138:2532

11 B Barber , J Dergousoff , L Slater , J Harris , D O'Connell , H El-Hakim Depression and survival in patients with head and neck cancer. JAMA Otolaryngol Neck Surg 2016;142:284–8

12 DJ Newport , CB Nemeroff . Review, assessment and treatment of depression in the cancer patient. J Psychosom Res 1998;45:215–37

13 W Söllner , A DeVries , E Steixner , P Lukas , G Sprinzl , G Rumpold How successful are oncologists in identifying patient distress, perceived social support, and need for psychosocial counselling? Br J Cancer 2001;84:179–85

14 A Vodermaier , W Linden , C Siu . Screening for emotional distress in cancer patients: a systematic review of assessment instruments. J Natl Cancer Inst 2009;101:1464–88

16 MR Katz , JC Irish , GM Devins , GM Rodin , PJ Gullane . Psychosocial adjustment in head and neck cancer: the impact of disfigurement, gender and social support. Head Neck 2003;25:103–12

17 ME Haisfield-Wolfe , DB McGuire , K Soeken , J Geiger-Brown , BR De Forge . Prevalence and correlates of depression among patients with head and neck cancer: a systematic review of implications for research. Oncol Nurs Forum 2009;36:E10725

18 ML Gillison , G D'Souza , W Westra , E Sugar , W Xiao , S Begum Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008;100:407–20

19 SS Baxi , AG Shuman , GW Corner , E Shuk , EJ Sherman , EB Elkin Sharing a diagnosis of HPV-related head and neck cancer: the emotions, the confusion, and what patients want to know. Head Neck 2013;35:1534–41

23 M Irwin , KH Artin , MN Oxman . Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Arch Intern Med 1999;159:1701–4

24 T Bjorgvinsson , SJ Kertz , JS Bigda-Peyton , KL McCoy , IM Aderka . Psychometric properties of the CES-D-10 in a psychiatric sample. Assessment 2013;20:429–36

26 CH Tu , MC Hsu , SC Chi , HY Lin , YC Yen . Routine depression screening and diagnosing strategy for cancer inpatients. Psychooncology 2014;23:1057–67

27 Y Adachi , H Kimura , N Sato , W Nagashima , K Nakamura , B Aleksic Preoperative level of depression is a predictor of postoperative levels of depression in patients with head and neck cancer. Jpn J Clin Oncol 2014;44:311–17

28 K Neilson , A Pollard , A Boonzaier , J Corry , D Castle , D Smith A longitudinal study of distress (depression and anxiety) up to 18 months after radiotherapy for head and neck cancer. Psychooncology 2013;22:1843–8

30 K Milbury , DI Rosenthal , A El-Naggar , H Badr . An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncol 2013;49:1067–71

31 CB Hess , DL Rash , ME Daly , DG Farwell , J Bishop , AT Vaughan Competing causes of death and medical comorbidities among patients with human papillomavirus-positive vs human papillomavirus-negative oropharyngeal carcinoma and impact on adherence to radiotherapy. JAMA Otolaryngol Head Neck Surg 2014;140:312–16

32 SP Moubayed , JS Sampalis , T Ayad , L Guertin , E Bissada , OE Gologan Predicting depression and quality of life among long-term head and neck cancer survivors. Otolaryngol Head Neck Surg 2015;152:91–7

33 R Koch , C Wittekindt , A Altendorf-Hoffmann , S Singer , O Guntinas-Lichius . Employment pathways and work-related issues in head and neck cancer survivors. Head Neck 2015;37:585–93

34 M Pinquart , P Duberstein . Depression and cancer mortality: a meta-analysis. Psychol Med 2010;40:1797–810

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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