Skip to main content
×
×
Home

Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer

  • J R Qualliotine (a1) (a2), J A Califano (a1) (a2) (a3), R J Li (a1) (a4), D Gold (a3), B Messing (a3), G Lee (a3), P Ha (a1) (a3) (a5) and C Fakhry (a1) (a3)...
Abstract
Background:

Several risk factors for depression in patients with oropharyngeal cancer have been determined. However, it is unknown whether human papillomavirus associated oropharyngeal cancer, which has a distinct clinico-demographic profile, modulates this risk.

Methods:

A retrospective analysis was conducted of patients with oropharyngeal cancer. These patients had completed a 10-item depression screening questionnaire before receiving treatment for their disease from 2011 to 2014. Associations between patient or disease characteristics and depression screening questionnaire results were investigated.

Results:

The study comprised 69 patients, 31 (44.9 per cent) of whom screened positive for depression. There were no significant differences in distributions of clinico-demographic or histopathological characteristics, including human papillomavirus tumour status, by depression screen result.

Conclusion:

This population has a high risk for depression, but no obvious risk factors, including human papillomavirus tumour status, were associated with an elevated risk. This inability to risk-stratify patients by clinico-demographic or disease characteristics emphasises the importance of regular depression screening for all patients in this population.

Copyright
Corresponding author
Address for correspondence: Dr Carole Fakhry, Department of Otolaryngology – Head and Neck Surgery, 601 N Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA Fax: +01 (410) 955 6526 E-mail: cfakhry@jhmi.edu
References
Hide All
1 Waraich, P, Goldner, EM, Somers, J, Hsu, L. Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry 2004;49:124–38
2 Krebber, AM, Buffart, LM, Kleijn, G, Riepma, IC, De Bree, R, Leemans, CR et al. Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self-report instruments. Psychooncology 2014;23:121–30
3 Neilson, KA, Pollard, AC, Boonzaier, AM, Corry, J, Castle, DJ, Mead, KR et al. Psychological distress (depression and anxiety) in people with head and neck cancers. Med J Aust 2010;193:S4851
4 Kugaya, A, Akechi, T, Okuyama, T, Nakano, T, Mikami, I, Okamura, H et al. Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer. Cancer 2000;88:2817–23
5 Barber, B, Dergousoff, J, Nesbitt, M, Mitchell, N, Harris, J, O'Connell, D et al. Depression as a predictor of postoperative functional performance status (PFPS) and treatment adherence in head and neck cancer patients: a prospective study. J Otolaryngol Head Neck Surg 2015;44:38
6 Kim, S-A, Roh, J-L, Lee, S-A, Lee, S, Kim, S-B, Choi, S-H et al. Pretreatment depression as a prognostic indicator of survival and nutritional status in patients with head and neck cancer. Cancer 2016;122:131–40
7 Hammerlid, E, Silander, E, Hörnestam, L, Sullivan, M. Health-related quality of life three years after diagnosis of head and neck cancer--a longitudinal study. Head Neck 2001;23:113–25
8 Hall, RC, Wise, MG. The clinical and financial burden of mood disorders. Cost and outcome. Psychosomatics 1995;36:S1118
9 Beck, D, Koenig, H. Minor depression: a review of the literature. Int J Psychiatry Med 1996;26:177209
10 Yu, GP, Mehta, V, Branovan, D, Huang, Q, Schantz, S. Non-cancer-related deaths from suicide, cardiovascular disease, and pneumonia in patients with oral cavity and oropharyngeal squamous carcinoma. Arch Otolaryngol Head Neck Surg 2012;138:2532
11 Barber, B, Dergousoff, J, Slater, L, Harris, J, O'Connell, D, El-Hakim, H et al. Depression and survival in patients with head and neck cancer. JAMA Otolaryngol Neck Surg 2016;142:284–8
12 Newport, DJ, Nemeroff, CB. Review, assessment and treatment of depression in the cancer patient. J Psychosom Res 1998;45:215–37
13 Söllner, W, DeVries, A, Steixner, E, Lukas, P, Sprinzl, G, Rumpold, G et al. How successful are oncologists in identifying patient distress, perceived social support, and need for psychosocial counselling? Br J Cancer 2001;84:179–85
14 Vodermaier, A, Linden, W, Siu, C. Screening for emotional distress in cancer patients: a systematic review of assessment instruments. J Natl Cancer Inst 2009;101:1464–88
15 Hirschfeld, R, Weissman, M. Risk factors for major depression and bipolar disorder. In: Davis, KL, Charney, D, Coyle, JT, Nemeroff, C, eds. Neuropsychopharmacology. Philadelphia: Lippincott, Williams & Wilkins, 2002;1018–25
16 Katz, MR, Irish, JC, Devins, GM, Rodin, GM, Gullane, PJ. Psychosocial adjustment in head and neck cancer: the impact of disfigurement, gender and social support. Head Neck 2003;25:103–12
17 Haisfield-Wolfe, ME, McGuire, DB, Soeken, K, Geiger-Brown, J, De Forge, BR. Prevalence and correlates of depression among patients with head and neck cancer: a systematic review of implications for research. Oncol Nurs Forum 2009;36:E10725
18 Gillison, ML, D'Souza, G, Westra, W, Sugar, E, Xiao, W, Begum, S et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008;100:407–20
19 Baxi, SS, Shuman, AG, Corner, GW, Shuk, E, Sherman, EJ, Elkin, EB et al. Sharing a diagnosis of HPV-related head and neck cancer: the emotions, the confusion, and what patients want to know. Head Neck 2013;35:1534–41
20 Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A. Pharynx. In: Edge, SB, Byrd, DR, Compton, CC, Fritz, AG, Greene, FL, Trotti, A, eds. AJCC Cancer Staging Manual, 7th edn. New York: Springer, 2010;4156
21 Begum, S, Gillison, ML, Ansari-Lari, MA, Shah, K, Westra, WH. Detection of human papillomavirus in cervical lymph nodes: a highly effective strategy for localizing site of tumor origin. Clin Cancer Res 2003;9:6469–75
22 Eaton, WW, Muntaner, C, Smith, C, Tien, A, Ybarra, M. Center for Epidemiologic Studies Depression Scale: Review and revision (CESD and CESD-R). In: Maruish, ME, ed. The Use of Psychological Testing for Treatment Planning and Outcomes Assessment, 3rd edn. Mahwah, New Jersey: Lawrence Erlbaum, 2004;363–77
23 Irwin, M, Artin, KH, Oxman, MN. Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Arch Intern Med 1999;159:1701–4
24 Bjorgvinsson, T, Kertz, SJ, Bigda-Peyton, JS, McCoy, KL, Aderka, IM. Psychometric properties of the CES-D-10 in a psychiatric sample. Assessment 2013;20:429–36
25 Andresen, EM, Malmgren, JA, Carter, WB, Patrick, DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med 1994;10:7784
26 Tu, CH, Hsu, MC, Chi, SC, Lin, HY, Yen, YC. Routine depression screening and diagnosing strategy for cancer inpatients. Psychooncology 2014;23:1057–67
27 Adachi, Y, Kimura, H, Sato, N, Nagashima, W, Nakamura, K, Aleksic, B et al. Preoperative level of depression is a predictor of postoperative levels of depression in patients with head and neck cancer. Jpn J Clin Oncol 2014;44:311–17
28 Neilson, K, Pollard, A, Boonzaier, A, Corry, J, Castle, D, Smith, D et al. A longitudinal study of distress (depression and anxiety) up to 18 months after radiotherapy for head and neck cancer. Psychooncology 2013;22:1843–8
29 Lydiatt, WM, Bessette, D, Schmid, KK, Sayles, H, Burke, WJ. Prevention of depression with escitalopram in patients undergoing treatment for head and neck cancer: randomized, double-blind, placebo-controlled clinical trial. JAMA Otolaryngol Neck Surg 2013;139:678–86
30 Milbury, K, Rosenthal, DI, El-Naggar, A, Badr, H. An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncol 2013;49:1067–71
31 Hess, CB, Rash, DL, Daly, ME, Farwell, DG, Bishop, J, Vaughan, AT et al. Competing causes of death and medical comorbidities among patients with human papillomavirus-positive vs human papillomavirus-negative oropharyngeal carcinoma and impact on adherence to radiotherapy. JAMA Otolaryngol Head Neck Surg 2014;140:312–16
32 Moubayed, SP, Sampalis, JS, Ayad, T, Guertin, L, Bissada, E, Gologan, OE et al. Predicting depression and quality of life among long-term head and neck cancer survivors. Otolaryngol Head Neck Surg 2015;152:91–7
33 Koch, R, Wittekindt, C, Altendorf-Hoffmann, A, Singer, S, Guntinas-Lichius, O. Employment pathways and work-related issues in head and neck cancer survivors. Head Neck 2015;37:585–93
34 Pinquart, M, Duberstein, P. Depression and cancer mortality: a meta-analysis. Psychol Med 2010;40:1797–810
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score