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Immunohistochemical evaluation with Ki-67: An application to salivary gland tumours

  • M. Murakami (a1), I. Ohtani (a1), H. Hojo (a2) and H. Wakasa (a2)
Abstract

Using Ki-67, a monoclonal antibody, the proliferating capacity of 15 salivary gland tumours, including nine pleomorphic adenomas, four adenoid cystic carcinomas, one mucoepidermoid carcinoma and one acinic cell carcinoma was determined immunohistochemically, using normal salivary gland tissue as a control. The frequency of Ki-67 positive cells was 4.7 per cent in the normal salivary gland and one per cent in pleomorphic adenomas, whereas the average frequency in malignant tumours was 18.3 per cent. Among adenoid cystic carcinomas, the frequency was related to the morphological type; the solid sub-type had the highest frequency of Ki-67-positive cells. As this sub-type is recognized as the most aggressive of these tumours, this technique has the potential of providing an early indication of the clinical behaviour of a tumour.

Copyright
COPYRIGHT: © JLO (1984) Limited 1992
Corresponding author
Dr M. Murakami, M.D., Matsukichyo 1–23, Fukushima City, Fukushima 960, Japan.
References
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Barnard, N. J., Hall, P. A., Lemoine, N. R., Kadar, N. (1987) Proliferative index in breast carcinoma determined in situ by Ki-67 immunostaining and its relationship to clinical and pathological variables. Journal of Pathology, 152: 287–295.
Gerdes, J., Schwab, U., Lemke, H., Stein, H. (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. International Journal of Cancer, 31: 13–20.
Gerdes, J., Lemke, H., Baisch, H., Wacker, H.H., Schwab, U., Stein, H. (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. Journal of Immunology, 133: 1710–1715.
Grogan, T. M., Lippmann, S. M., Spier, C. M., Slymen, D. J., Rybski, J. A., Rangel, C. S., Richter, L. C., Miller, T. P. (1988) Independent prognostic significance of a nuclear proliferation antigen in difuse large cell lymphoma as determined by the monoclonal antibody Ki-67. Blood, 171: 1157–1160.
Hall, P. A., Richards, M. M., Gregory, W. M., d'Ardenne, A. J., Lister, T. A., Stansfeld, A. G. (1988) The prognostic value of Ki-67 immunostaining in non-Hodgkin's lymphoma. Journal of Pathology, 154: 223–235.
Lorz, M., Meyer-Breiting, E. (1988) Evaluation of proliferative activity in human head and neck tumor using the monoclonal antibody Ki-67. Otorhinolaryngology, 50: 183–187.
Shibata, T., Burger, P. C., Kleihues, P. (1988) Cell kinetics of oligodendroglioma and oligo-astrocytoma. Ki-67 PAP study. No To Shinkei (Japan), 40: 779–785.
Sternberger, L. A., Hardy, P. H., Cuculis, J. J., Meyer, H. G. (1970) The unlabelled antibody enzyme method of immunochemistry. Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase anti horseradish peroxidase) and its use in identification of spirochates. Journal of Histochemistry and Cytochemistry, 18: 315–333.
Weiss, L. M., Strickler, J. G., Medeiros, L. J., Gerdes, J., Stein, H., Warnke, R. A. (1987) Proliferative rates of non-Hodgkin'slymphomas as assessed by Ki-67 antibody. Human Pathology, 18: 1155–1159.
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
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