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Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss

  • S H Yoon (a1), M E Kim (a2), H Y Kim (a1), J S Lee (a2) and C H Jang (a1)...
Abstract
Objective

This study evaluated tumour necrosis factor-α, interleukins 10 and 12, and interferon-γ levels, peripheral blood mononuclear cells, and clusters of differentiation 17c and 86 expression in unilateral sudden sensorineural hearing loss.

Methods

Twenty-four patients with unilateral sudden sensorineural hearing loss, and 24 individuals with normal hearing and no history of sudden sensorineural hearing loss (who were attending the clinic for other problems), were enrolled. Peripheral blood mononuclear cells, and clusters of differentiation 11c and 86 were isolated and analysed. Plasma and supernatant levels of tumour necrosis factor-α, interferon-γ, and interleukins 10 and 12 were measured.

Results

There were no significant differences with respect to age and gender. Monocyte population, mean tumour necrosis factor-α level and cluster of differentiation 86 expression were significantly increased in the study group compared to the control group. However, interferon-γ and interleukin 12 levels were significantly decreased. The difference in mean interleukin 10 level was not significant.

Conclusion

Increases in tumour necrosis factor-α level and monocyte population might play critical roles in sudden sensorineural hearing loss. This warrants detailed investigation and further studies on the role of dendritic cells in sudden sensorineural hearing loss.

Copyright
Corresponding author
Author for correspondence: Dr Jun-Sik Lee, Department of Life Science, BK 21-plus Research Team for Bioactive Control Technology, Biology, College of Natural Science, Chosun University, Gwangju, South Korea E-mail: junsiklee@chosun.ac.kr Fax: +822308850
Dr Chul Ho Jang, Department of Otolaryngology, Chonnam National University Hospital, Hakdong 8, Dongku, Gwangju, South Korea E-mail: jchsavio@gmail.com Fax: +82 6222 06776
Footnotes
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Dr C H Jang takes responsibility for the integrity of the content of the paper

SH Yoon and ME Kim, both two authors contributed equally to this work.

Footnotes
References
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  • ISSN: 0022-2151
  • EISSN: 1748-5460
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