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Investigation of smell and taste function in patients with obstructive sleep apnoea syndrome

  • A Yenigun (a1), N Degirmenci (a1), S S Goktas (a1), R Dogan (a1) and O Ozturan (a1)...

Abstract

Objective

This study investigated the relationship between disease severity and taste and smell functions in patients with obstructive sleep apnoea syndrome.

Methods

A total of 65 patients with recurrent upper airway obstruction during sleep were included. Participants were divided into four groups according to apnoea-hypopnoea index, obtained on polysomnography. Smell and taste tests were performed on these patients.

Results

A significant difference was observed between the smell thresholds of the groups for the identification test (p = 0.016). In the taste test, significant differences were observed between the groups in terms of sweet, sour, salty and bitter taste test thresholds (p = 0.029, p = 0.0005, p = 0.001 and p = 0.017, respectively).

Conclusion

As sleep apnoea severity increased (according to the apnoea-hypopnoea index) in obstructive sleep apnoea syndrome patients, the taste and smell thresholds decreased due to the effect of neuropathy and inflammation in the upper respiratory tract.

Copyright

Corresponding author

Author for correspondence: Dr Alper Yenigun, Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Boulevard, Vatan Street, 34093 Fatih, Istanbul, Turkey E-mail: alperyenigun@gmail.com Fax: +90 (212) 453 18 70

Footnotes

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Dr A Yenigun takes responsibility for the integrity of the content of the paper

Footnotes

References

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1Silva, GE, An, M-W, Goodwin, JL, Shahar, E, Redline, S, Resnick, H et al. Longitudinal evaluation of sleep-disordered breathing and sleep symptoms with change in quality of life: the Sleep Heart Health Study (SHHS). Sleep 2009;32:1049–57
2Berger, G, Berger, R, Oksenberg, A. Progression of snoring and obstructive sleep apnoea: the role of increasing weight and time. Eur Respir J 2009;33:338–45
3Andrews, JG, Oei, TPS. The roles of depression and anxiety in the understanding and treatment of obstructive sleep apnea syndrome. Clin Psychol Rev 2004;24:1031–49
4Kushida, CA, Littner, MR, Morgenthaler, T, Alessi, CA, Bailey, D, Coleman, J et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 2005;28:499521
5Yarmolinsky, DA, Zuker, CS, Ryba, NJP. Common sense about taste: from mammals to insects. Cell 2009;139:234–44
6Fark, T, Hummel, C, Hähner, A, Nin, T, Hummel, T. Characteristics of taste disorders. Eur Arch Otorhinolaryngol 2013;270:1855–60
7Landis, BN, Welge-Luessen, A, Brämerson, A, Bende, M, Mueller, CA, Nordin, S et al. “Taste Strips” - a rapid, lateralized, gustatory bedside identification test based on impregnated filter papers. J Neurol 2009;256:242–8
8Takeuchi, T, Futatsuka, M, Imanishi, H, Yamada, S. Pathological changes observed in the finger biopsy of patients with vibration-induced white finger. Scand J Work Environ Health 1986;12:280–3
9Strömberg, T, Dahlin, LB, Lundborg, G. Hand problems in 100 vibration-exposed symptomatic male workers. J Hand Surg Br 1996;21:315–19
10Virokannas, H. Dose-response relation between exposure to two types of hand-arm vibration and sensorineural perception of vibration. Occup Environ Med 1995;52:332–6
11Svanborg, E. Impact of obstructive apnea syndrome on upper airway respiratory muscles. Respir Physiol Neurobiol 2005;147:263–72
12Yenigun, A, Karamanli, H. Investigation of the relationship between neutrophil-to-lymphocyte ratio and obstructive sleep apnoea syndrome. J Laryngol Otol 2015;129:887–92
13Hori, T, Sugita, Y, Koga, E, Shirakawa, S, Inoue, K, Uchida, S et al. Proposed supplements and amendments to ‘A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects’, the Rechtschaffen & Kales (1968) standard. Psychiatry Clin Neurosci 2001;55:305–10
14Gould, GA, Whyte, KF, Rhind, GB, Airlie, MA, Catterall, JR, Shapiro, CM et al. The sleep hypopnea syndrome. Am Rev Respir Dis 1988;137:895–8
15Cain, WS, Gent, JF, Goodspeed, RB, Leonard, G. Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 1988;98:83–8
16Garvey, JF, Taylor, CT, McNicholas, WT. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Eur Respir J 2009;33:1195–205
17Friberg, D, Ansved, T, Borg, K, Carlsson-Nordlander, B, Larsson, H, Svanborg, E. Histological indications of a progressive snorers disease in an upper airway muscle. Am J Respir Crit Care Med 1998;157:586–93
18Hagander, L, Harlid, R, Svanborg, E. Quantitative sensory testing in the oropharynx: a means of showing nervous lesions in patients with obstructive sleep apnea and snoring. Chest 2009;136:481–9
19Kimoff, RJ, Sforza, E, Champagne, V, Ofiara, L, Gendron, D. Upper airway sensation in snoring and obstructive sleep apnea. Am J Respir Crit Care Med 2001;164:250–5
20Guilleminault, C, Li, K, Chen, N-H, Poyares, D. Two-point palatal discrimination in patients with upper airway resistance syndrome, obstructive sleep apnea syndrome, and normal control subjects. Chest 2002;122:866–70
21Nguyen, ATD, Jobin, V, Payne, R, Beauregard, J, Naor, N, Kimoff, RJ. Laryngeal and velopharyngeal sensory impairment in obstructive sleep apnea. Sleep 2005;28:585–93
22Mackenzie, RA, Skuse, NF, Lethlean, AK. A micro-electrode study of peripheral neuropathy in man. Part 1. Responses to single graded stimuli. J Neurol Sci 1977;34:157–74
23Friberg, D, Gazelius, B, Hökfelt, T, Nordlander, B. Abnormal afferent nerve endings in the soft palatal mucosa of sleep apnoics and habitual snorers. Regul Pept 1997;71:2936
24Friberg, D, Gazelius, B, Lindblad, LE, Nordlander, B. Habitual snorers and sleep apnoics have abnormal vascular reactions of the soft palatal mucosa on afferent nerve stimulation. Laryngoscope 1998;108:431–6
25Sunnergren, O, Broström, A, Svanborg, E. Soft palate sensory neuropathy in the pathogenesis of obstructive sleep apnea. Laryngoscope 2011;121:451–6
26Jeong, KH, Yang, Y, Choi, HR, Cho, JH, Kim, GT, Kim, JK. Assessment of change in palatal sensation in obstructive sleep apnea patients by using two-point palatal discrimination. Clin Exp Otorhinolaryngol 2016;9:226–32
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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