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Juvenile nasopharyngeal angiofibroma: a single centre's 11-year experience

  • A E Pamuk (a1), S Özer (a2), A E Süslü (a2), A Akgöz (a3) and M Önerci (a2)...
Abstract
Objective

This study aimed to present the clinical features and surgical outcomes of juvenile nasopharyngeal angiofibroma patients who were surgically treated.

Methods

The medical records of 48 male patients histologically confirmed as having juvenile nasopharyngeal angiofibroma, who underwent transnasal endoscopic surgery between 2005 and 2016, were retrospectively reviewed.

Results

The overall recurrence rate was 20.8 per cent; however, the recurrence rate differed significantly between patients diagnosed aged less than 14 years (34.7 per cent) and more than 14 years (8 per cent) (p < 0.05). Advanced-stage tumours (Radkowski stage of IIC or more, and Önerci stage of III or more) were more aggressive than earlier stage tumours (p < 0.05 and p < 0.01, respectively). Pre-operative embolisation significantly prolonged mean hospitalisation duration, but had no effect on intra-operative blood loss in patients with advanced-stage tumours (p < 0.001 and p = 0.09, respectively).

Conclusion

The findings show that transnasal endoscopic surgery could be considered the treatment of choice for juvenile nasopharyngeal angiofibroma. Patients diagnosed when aged less than 14 years and those with advanced-stage tumours are at risk of recurrence, and should be monitored with extreme care.

Copyright
Corresponding author
Author for correspondence: Dr Ahmet Erim Pamuk, Department of Otorhinolaryngology, Akyurt State Hospital, 06750 Akyurt – Ankara, Turkey E-mail: dr_erim@hotmail.com Fax: +90 312 844 3016
Footnotes
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Dr A E Pamuk takes responsibility for the integrity of the content of the paper

Footnotes
References
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1Midilli, R, Karci, B, Akyildiz, S. Juvenile nasopharyngeal angiofibroma: analysis of 42 cases and important aspects of endoscopic approach. Int J Pediatr Otolaryngol 2009;73:401–8
2Nicolai, P, Schreiber, A, Bolzoni Villaret, A. Juvenile angiofibroma: evolution of management. Int J Pediatr 2012;2012:412545
3Farag, MM, Ghanimah, SE, Ragaie, A, Saleem, TH. Hormonal receptors in juvenile nasopharyngeal angiofibroma. Laryngoscope 1987;97:208–11
4Coutinho-Camillo, CM, Brentani, MM, Nagai, MA. Genetic alterations in juvenile nasopharyngeal angiofibromas. Head Neck 2008;30:390400
5Schick, B, Plinkert, PK, Prescher, A. Aetiology of angiofibromas: reflection on their specific vascular component [in German]. Laryngorhinootologie 2002;81:280–4
6Beham, A, Beham-Schmid, C, Regauer, S, Aubock, L, Stammberger, H. Nasopharyngeal angiofibroma: true neoplasm or vascular malformation? Adv Anat Pathol 2000;7:3646
7Onerci, M, Ogretmenoglu, O, Yucel, T. Juvenile nasopharyngeal angiofibroma: a revised staging system. Rhinology 2006;44:3945
8Radkowski, D, McGill, T, Healy, GB, Ohlms, L, Jones, DT. Angiofibroma. Changes in staging and treatment. Arch Otolaryngol Head Neck Surg 1996;122:122–9
9Herman, P, Lot, G, Chapot, R, Salvan, D, Huy, PT. Long-term follow-up of juvenile nasopharyngeal angiofibromas: analysis of recurrences. Laryngoscope 1999;109:140–7
10Nicolai, P, Villaret, AB, Farina, D, Nadeau, S, Yakirevitch, A, Berlucchi, M et al. Endoscopic surgery for juvenile angiofibroma: a critical review of indications after 46 cases. Am J Rhinol Allergy 2010;24:6772
11Enepekides, DJ. Recent advances in the treatment of juvenile angiofibroma. Curr Opin Otolaryngol Head Neck Surg 2004;12:495–9
12Glad, H, Vainer, B, Buchwald, C, Petersen, BL, Theilgaard, SA, Bonvin, P et al. Juvenile nasopharyngeal angiofibromas in Denmark 1981–2003: diagnosis, incidence, and treatment. Acta Otolaryngol 2007;127:292–9
13Huang, Y, Liu, Z, Wang, J, Sun, X, Yang, L, Wang, D. Surgical management of juvenile nasopharyngeal angiofibroma: analysis of 162 cases from 1995 to 2012. Laryngoscope 2014;124:1942–6
14Howard, DJ, Lloyd, G, Lund, V. Recurrence and its avoidance in juvenile angiofibroma. Laryngoscope 2001;111:1509–11
15Sun, XC, Wang, DH, Yu, HP, Wang, F, Wang, W, Jiang, JJ. Analysis of risk factors associated with recurrence of nasopharyngeal angiofibroma. J Otolaryngol Head Neck Surg 2010;39:5661
16Liu, L, Wang, R, Huang, D, Han, D, Ferguson, EJ, Shi, H et al. Analysis of intra-operative bleeding and recurrence of juvenile nasopharyngeal angiofibromas. Clin Otolaryngol Allied Sci 2002;27:536–40
17Li, JR, Qian, J, Shan, XZ, Wang, L. Evaluation of the effectiveness of preoperative embolization in surgery for nasopharyngeal angiofibroma. Eur Arch Otorhinolaryngol 1998;255:430–2
18Lutz, J, Holtmannspötter, M, Flatz, W, Meier-Bender, A, Berghaus, A, Brückmann, H et al. Preoperative embolization to improve the surgical management and outcome of juvenile nasopharyngeal angiofibroma (JNA) in a single center: 10-year experience. Clin Neuroradiol 2015;26:405–13
19Mohammadi, M, Saedi, B, Basam, A. Effect of embolisation on endoscopic resection of angiofibroma. J Laryngol Otol 2010;124:631–5
20Onerci, M, Gumus, K, Cil, B, Eldem, B. A rare complication of embolization in juvenile nasopharyngeal angiofibroma. Int J Pediatr Otorhinolaryngol 2005;69:423–8
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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