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Ménière's disease clinical subtypes in a population from the USA

  • J Crossley (a1) (a2), A S Hussaini (a2), H J Kim (a2) and M Hoa (a2)



To ascertain the distribution of Ménière's disease phenotype subgroups in a US-based cohort, based on a recently introduced classification scheme utilising a Spanish and Portuguese cohort.


A retrospective, cross-sectional, single-institutional chart review was conducted. The electronic medical records of Ménière's disease patients were identified using International Classification of Diseases codes at a tertiary referral centre and reviewed to extract subgroup-defining features. Patients with definite Ménière's disease as per American Academy of Otolaryngology–Head and Neck Surgery criteria were categorised into one of five subgroups, for unilateral and bilateral Ménière's disease.


Eighty-one patients with definite Ménière's disease were identified. Seventy-two cases of unilateral Ménière's disease were observed: 52.8 per cent were type 1, 20.8 per cent were type 2, 4.2 per cent were type 3, 18.1 per cent were type 4, and 4.2 per cent were type 5. This cohort differed significantly in distribution to a comparison Mediterranean cohort (p < 0.01). Nine cases of bilateral Ménière's disease were observed.


The distribution of unilateral Ménière's disease subtypes in this US population was different from that observed in a European population.


Corresponding author

Author for correspondence: Dr J Crossley, Department of Otolaryngology – Head and Neck Surgery, MedStar Georgetown University Hospital, 1st Floor, Gorman Building, 3800 Reservoir Road NW, Washington, DC20007, USA E-mail:


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Dr J Crossley takes responsibility for the integrity of the content of the paper



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1Chaves, AG, Boari, L, Lei Munhoz, MS. The outcome of patients with Ménières disease. Braz J Otorhinolaryngol 2007;73:346–50
2Stahle, J, Friberg, U, Svedberg, A. Long-term progression of Menière's disease. Am J Otol 1989;10:170–3
3Hallpike, CS, Cairns, H. Observations on the pathology of Meniere's syndrome. Proc R Soc Med 1938;31:1317–36
4Foster, CA, Breeze, RE. The Meniere attack: an ischemia/reperfusion disorder of inner ear sensory tissues. Med Hypotheses 2013;81:1108–15
5Merchant, SN, Adams, JC, Nadol, JB. Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops? Otol Neurotol 2005;26:7481
6Lopez-Escamez, JA, Carey, J, Chung, W, Goebel, JA, Magnusson, M, Mandalà, M et al. Diagnostic criteria for Menière's disease. J Vestib Res 2015;25:17
7Hoa, M, Friedman, RA, Fisher, LM, Derebery, MJ. Prognostic implications of and audiometric evidence for hearing fluctuation in Meniere's disease. Laryngoscope 2015;125(suppl 12):S112
8Wright, T. Menière's disease. BMJ Clin Evid 2015;2015:0505
9Frejo, L, Soto-Varela, A, Santos-Perez, S, Aran, I, Batuecas-Caletrio, A, Perez-Guillen, V et al. Clinical subgroups in bilateral Meniere disease. Front Neurol 2016;7:182
10Frejo, L, Martin-Sanz, E, Teggi, R, Trinidad, G, Soto-Varela, A, Santos-Perez, S et al. Extended phenotype and clinical subgroups in unilateral Meniere disease: a cross-sectional study with cluster analysis. Clin Otolaryngol 2017;42:1172–80
11Requena, T, Espinosa-Sanchez, JM, Cabrera, S, Trinidad, G, Soto-Varela, A, Santos-Perez, S et al. Familial clustering and genetic heterogeneity in Meniere's disease. Clin Genet 2014;85:245–52
12Kim, HK, Lee, HJ, An, SY, Sim, S, Park, B, Kim, SW et al. Analysis of the prevalence and associated risk factors of tinnitus in adults. PLoS One 2015;10:e0127578
13Bruderer, SG, Bodmer, D, Stohler, NA, Jick, SS, Meier, CR. Population-based study on the epidemiology of Ménière's disease. Audiol Neurootol 2017;22:7482
14Gaur, K, Kasliwal, N, Gupta, R. Association of smoking or tobacco use with ear diseases among men: a retrospective study. Tob Induc Dis 2012;10:4
15Huppert, D, Strupp, M, Brandt, T. Long-term course of Meniere's disease revisited. Acta Otolaryngol 2010;130:644–51
16House, JW, Doherty, JK, Fisher, LM, Derebery, JM, Berliner, KI. Meniere's disease: prevalence of contralateral ear involvement. Otol Neurotol 2006;27:355–61


Ménière's disease clinical subtypes in a population from the USA

  • J Crossley (a1) (a2), A S Hussaini (a2), H J Kim (a2) and M Hoa (a2)


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