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A method for preparation of fibrin glue

  • L. H. Durham (a1), D. J. Willatt (a1), M. W. Yung (a1), I. Jones (a2), P. A. Stevenson (a2) and M. F. Ramadan (a1)...

Abstract

Otorhinolaryngological operations would be facilitated by the use of a safe, cheap, surgical adhesive. Though commercial fibrin glue is effective, it is both relatively expensive and, because it is prepared from pooled human blood, there has been concern that it carries the risk of transmitting viral disease, in particular hepatitis and acquired immune deficiency syndrome. We describe a rapid, cheap method of preparing sufficient fibrin glue, of adequate bonding power, from a small quantity of the patient's own blood, and therefore with no risk of contracting viral disease. Our method of preparation of fibrin glue promises to provide a valuable adjunct to otorhinolaryngological surgical practice.

Copyright

Corresponding author

Mr. L. H. Durham, Department of Otorhinolaryngology, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF.

References

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Harker, L. A. and Slichter, S. J. (1972) Platelet and fibrinogen consumption in man. New England Journal of Medicine, 287: 9991005.
O'Conner, A. F. and Shea, J. J. (1982) A biologic adhesive for otologic practice. Otolaryngology—Head and Neck Surgery, 90: 347348.
Panis, R. (1982) Human fibrinogen tissue adhesive, a new tool in middle ear surgery. Journal of Head and Neck Pathology, 3: 9495.
Siedentop, K. H., Harris, D. M. and Loewy, A. (1983) Experimental use of fibrin tissue adhesive in middle ear surgery. Laryngoscope, 93: 13101313.
Staindl, O. (1979) Tissue adhesion with highly concentrated human fibrinogen in otolaryngology. Annals of Otology, Rhinology and Laryngology, 88: 413– 418.
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Wingand, M. E. and Panis, R. (1981) Fibrin glue in microsurgery of the middle ear. Clinical Otolaryngology, 6: 127.
Wolf, G. (1983) Der konzentrierte autologe gewebekleber. Archives of Otorhinolaryngology, 237: 279283.
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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