Skip to main content Accessibility help
×
Home

A novel prognostic biomarker for recurrent aphthous stomatitis: calprotectin

  • S Kayabasi (a1) and I Kuzucu (a1)

Abstract

Objective

This study aims to investigate whether there is a correlation between serum calprotectin concentration and oral ulcer activity in patients with active recurrent aphthous stomatitis.

Method

This prospective, cross-sectional, historical cohort study included 52 patients (26 with active lesions and 26 with inactive lesions) with recurrent aphthous stomatitis and 27 healthy volunteers. The relationship between the groups was statistically evaluated in terms of serum calprotectin level and other inflammatory parameters.

Results

The median calprotectin value of the active lesion group (80.5 ng/ml) was significantly higher than that of the control group (55.4 ng/ml, p = 0.002). Furthermore, the median calprotectin value of the active lesion group was significantly higher than that of the inactive lesion group (72.5 ng/ml, p = 0.017).

Conclusion

In patients with recurrent aphthous stomatitis and active ulcer lesions, the serum calprotectin value can be used as a reliable and robust prognostic marker for inflammation.

Copyright

Corresponding author

Author for correspondence: Dr Serkan Kayabasi, Department of ENT, Faculty of Medicine, Aksaray University, Aksaray 68100, Turkey E-mail: drserkankayabasi@gmail.com Fax: +90 382 2119100

Footnotes

Hide All

Dr S Kayabasi takes responsibility for the integrity of the content of the paper

Footnotes

References

Hide All
1Jurge, S, Kuffer, R, Scully, C, Porter, SR. Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006;12:121
2Ślebioda, Z, Szponar, E, Kowalska, A. Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review. Arch Immunol Ther Exp (Warsz) 2014;62:205–1510.1007/s00005-013-0261-y
3Greenberg, MS, Pinto, A. Etiology and management of recurrent aphthous stomatitis. Curr Infect Dis Rep 2003;5:194–8
4Pedersen, A, Ryder, LP. Gamma delta T-cell fraction of peripheral blood is increased in recurrent aphthous ulceration. Clin Immunol Immunopathol 1994;72:98104.
5Ozler, GS. Zinc deficiency in patients with recurrent aphthous stomatitis: a pilot study. J Laryngol Otol 2014;128:531–3.
6El-Rıfai, W, Moskaluk, CA, Abdrabbo, MK, Harper, J, Yoshida, C, Riggins, GJ et al. Gastric cancers overexpress S100A calcium-binding proteins. Cancer Res 2002;62:6823–6
7Stříž, I, Trebichavský, I. Calprotectin—a pleiotropic molecule in acute and chronic inflammation. Physiol Res 2004;53:245–53
8Dale, I, Brandtzaeg, P. Expression of the epithelial L1 antigen as an immunohistochemical marker of squamous cell carcinoma of the lung. Histopathology 1989;14:49350210.1111/j.1365-2559.1989.tb02185.x
9Mumcu, G, Sur, H, Inanc, N, Karacayli, U, Cimilli, H, Sisman, N et al. A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. Journal Oral Pathol Med 2009;38:785–91
10Natah, SS, Häyrinen-Immonen, R, Hietanen, J, Patinen, P, Malmström, M, Savilahti, E et al. Increased density of lymphocytes bearing γ/δ T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 2000;29:375–80
11Porter, S, Scully, C. Aphthous stomatitis—an overview of aetiopathogenesis and management. Clin Exp Dermatol 1991;16:235–43
12Boussac, M, Garin, J. Calcium-dependent secretion in human neutrophils: a proteomic approach. Electrophoresis 2000;21:665–72
13Topuz, MF, Binnetoglu, A, Yumusakhuylu, AC, Sarı, M, Baglam, T, Gerin, F. Circulating calprotectin as a biomarker of laryngeal carcinoma. Eur Arch Otorhinolaryngol 2017;274:2499–504
14Arai, K, Teratani, T, Kuruto-Niwa, R, Yamada, T, Nozawa, R. S100A9 expression in invasive ductal carcinoma of the breast: S100A9 expression in adenocarcinoma is closely associated with poor tumour differentiation. Eur J Cancer 2004;40:1179–87
15Arai, K, Yamada, T, Nozawa, R. Immunohistochemical investigatigation of migration inhibitory factor-related protein (MRP)-14 expression in hepatocellular carcinoma. Med Oncol 2000;17:183–8
16Ozler, GS, Akoglu, E. The relationship between neutrophil to lymphocyte ratio and recurrent aphthous stomatitis. JCAM 2016;7:152–4
17Ekiz, O, Balta, I, Sen, BB, Rifaioglu, EN, Ergin, C, Balta, S et al. Mean platelet volume in recurrent aphthous stomatitis and Behçet disease. Angiology 2014;65:161–5
18Alan, S, Tuna, S, Türkoğlu, E. The relation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume with the presence and severity of Behcet's syndrome. Kaohsiung J Med Sci 2015;31:626–31
19Kristinsson, J, Roseth, A, Fagerhol, MK, Aadland, E, Schjonsby, H, Bormer, OP et al. Fecal calprotectin concentration in patients with colorectal carcinoma. Dis Colon Rectum 1998;41:316–2110.1007/BF02237485

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed