Hostname: page-component-7c8c6479df-8mjnm Total loading time: 0 Render date: 2024-03-26T16:19:08.884Z Has data issue: false hasContentIssue false

Olfactory event-related potentials: a new approach for the evaluation of olfaction in nasopharyngeal carcinoma patients treated with chemo-radiotherapy

Published online by Cambridge University Press:  02 March 2016

B Galletti
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
R Santoro
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
V K Mannella
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
F Caminiti
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
L Bonanno
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
S De Salvo
Affiliation:
Department of Research, Istituto di Ricovero e Cura a Carattere Scientifico (‘IRCCS’) Centro Neurolesi ‘Bonino Pulejo’, Messina, Italy
G Cammaroto*
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
F Galletti
Affiliation:
Department of Otorhinolaryngology, University of Messina, Messina, Italy
*
Address for correspondence: Dr Giovanni Cammaroto, Department of Otorhinolaryngology, Policlinico Universitario, Via Consolare Valeria, 98100 Messina, Italy Fax: +39 (090) 221 2257 E-mail: giovanni.cammaroto@hotmail.com

Abstract

Objective:

Olfactory dysfunction is a possible side effect of chemo-radiotherapy performed in patients affected by nasopharyngeal carcinoma. Self-rating measurements and olfactory event-related potentials were used and compared in order to evaluate the impact of this treatment on the olfactory system.

Methods:

Nine patients underwent subjective evaluation of olfactory function (using visual analogue scales for olfactory symptoms and quality of life, and a six-item Hyposmia Rating Scale), and a quantitative and objective measurement (olfactory event-related potentials).

Results:

Spearman's rank correlation analyses highlighted significant relationships between the clinical scales and olfactory event-related potentials. Inter-group analyses showed significant differences in the latency and in the amplitude of olfactory event-related potentials between patients and controls.

Conclusion:

Taking into account the small sample size and the lack of pre-treatment assessment, olfactory event-related potentials seemed to allow a more objective diagnosis of unilateral and bilateral olfactory loss. Moreover, olfactory event-related potentials and subjective scales results were concordant.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Wenig, BM. Nasopharyngeal carcinoma. Ann Diagn Pathol 1999;3:374–85Google Scholar
2 Black, RJ, Bray, F, Ferlay, J, Parkin, DM. Cancer incidence and mortality in the European Union: cancer registry data and estimates of national incidence for 1990. Eur J Cancer 1997;33:1075–107CrossRefGoogle Scholar
3 Yu, MC, Yuan, JM. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 2002;12:421–9CrossRefGoogle ScholarPubMed
4 Ren, JS, Chen, WQ, Shin, HR, Ferlay, J, Saika, K, Zhang, SW et al. A comparison of two methods to estimate the cancer incidence and mortality burden in China in 2005. Asian Pac J Cancer Prev 2010;11:1587–94Google Scholar
5 Chang, ET, Adami, HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:1765–77CrossRefGoogle ScholarPubMed
6 Kam, MK, Chau, RM, Suen, J. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys 2003;56:145–57Google Scholar
7 Lee, N, Xia, P, Quivey, JM, Sultanem, K, Poon, I, Akazawa, C et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys 2002;53:1222 Google Scholar
8 Geara, FB, Glisson, BS, Sanguineti, G, Tucker, SL, Garden, AS, Ang, KK et al. Induction chemotherapy followed by radiotherapy versus radiotherapy alone in patients with advanced nasopharyngeal carcinoma: results of a matched cohort study. Cancer 1997;79:1279–863.0.CO;2-C>CrossRefGoogle ScholarPubMed
9 Chua, DT, Sham, JS, Choy, D, Lorvidhaya, V, Sumitsawan, Y, Thongprasert, S et al. Preliminary report of the Asian–Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Cancer 1998;83:2270–83Google Scholar
10 Al-Sarraf, M, Pajak, TF, Cooper, JS, Mohiuddin, M, Herskovic, A, Ager, PJ. Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma: a radiation therapy oncology group study. J Clin Oncol 1990;8:1342–51Google Scholar
11 Al-Sarraf, M, LeBlanc, M, Giri, PG, Fu, KK, Cooper, J, Vuong, T et al. Chemotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998;16:1310–17Google Scholar
12 Dimery, IW, Legha, SS, Peters, LJ, Goepfert, H, Oswald, MJ. Adjuvant chemotherapy for advanced nasopharyngeal carcinoma. Cancer 1987;60:943–9Google Scholar
13 Decker, DA, Drelichman, A, Al-Sarraf, M. Chemotherapy for nasopharyngeal carcinoma: a ten-year experience. Cancer 1983;52:602–5Google Scholar
14 Maes, A, Huygh, I, Weltens, C, Vandevelde, G, Delaere, P, Evers, G et al. De Gustibus: time scale of loss and recovery of tastes caused by radiotherapy. Radiother Oncol 2002;63:195201 CrossRefGoogle ScholarPubMed
15 Mossman, KL, Shatzman, A, Chencharick, J. Long-term effects of radiotherapy on taste and salivary function in man. Int J Radiat Oncol Biol Phys 1982;8:991–7Google Scholar
16 Temmel, AF, Quint, C, Schickinger-Fischer, B, Klimek, L, Stoller, E, Hummel, T. Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 2002;128:635–41Google Scholar
17 Ravasco, P. Aspects of taste and compliance in patients with cancer. Eur J Oncol Nurs 2005;9:S84–91Google Scholar
18 Hua, MS, Chen, ST, Tang, LM, Leung, WM. Olfactory function in patients with nasopharyngeal carcinoma following radiotherapy. Brain Inj 1999;13:905–15Google Scholar
19 Bramerson, A, Nyman, J, Nordin, S, Bende, M. Olfactory loss after head and neck cancer radiation therapy. Rhinology 2013;51:206–9CrossRefGoogle ScholarPubMed
20 Ho, W-K, Kwong, DL, Wei, WI, Sham, JS. Change in olfaction after radiotherapy for nasopharyngeal cancer – a prospective study. Am J Otolaryngol 2002;23:209–14Google Scholar
21 Millar, Vernetti P, Perez, Lloret S, Rossi, M, Cerquetti, D, Merello, M. Validation of new scale to assess olfactory dysfunction in patients with Parkinson's disease. Parkinsonism Relat Disord 2012;18:358–61CrossRefGoogle Scholar
22 Rombaux, P, Mouraux, A, Bertrand, B, Guerit, JM, Hummel, T. Assessment of olfactory and trigeminal function using chemosensory event-related potentials. Clin Neurophysiol 2006;36:5362 CrossRefGoogle ScholarPubMed
23 Barresi, M, Ciurleo, R, Giacoppo, S, Foti, Cuzzola V, Celi, D, Pramanti, P et al. Evaluation of olfactory dysfunction in neurodegenerative diseases. J Neurol Sci 2012;323:1624 CrossRefGoogle ScholarPubMed
24 Caminiti, F, Ciurleo, R, Bramanti, P, Marino, S. Persistent anosmia in a traumatic brain injury patient: role of orbitofrontal cortex. Brain Inj 2013;27:1715–18Google Scholar
25 Caminiti, F, De Salvo, S, De Cola, MC, Russo, M, Bramanti, P, Marino, S et al. Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. PLoS One 2014;9:e103151Google Scholar
26 Greene, FL, Page, DL, Fleming, ID, Fritz, AG, Balch, CM, Haller, DG et al. AJCC Cancer Staging Handbook: From the AJCC Cancer Staging Manual, 6th edn. New York: Springer-Verlag, 2002;50–2Google Scholar
27 Hummel, T, Konnerth, CG, Rosenheim, K, Kobal, G. Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss. Ann Otol Rhinol Laryngol 2001;110:976–81CrossRefGoogle ScholarPubMed
28 Hölscher, T, Seibt, A, Appold, S, Dorr, W, Herrmann, T, Huttenbrink, KB et al. Effects of radiotherapy on olfactory function. Radiother Oncol 2005;77:157–63Google Scholar
29 Nakamura, H, Nonomura, N, Fujiwara, M, Nakano, Y. Olfactory disturbances caused by the anti-cancer drug tegafur. Eur Arch Otorhinolaryngol 1995;252:4852 CrossRefGoogle ScholarPubMed
30 Rhodes, VA, McDaniel, RW, Hanson, B, Markway, E, Johnson, M. Sensory perception of patients on selected antineoplastic chemotherapy protocols. Cancer Nurs 1994;17:4551 Google Scholar
31 de Graeff, A, de Leeuw, JR, Ros, WJ, Blijham, GH, Hordijk, GJ, Winnubst, JA. Long-term quality of life of patients with head and neck cancer. Laryngoscope 2000;110:98106 CrossRefGoogle ScholarPubMed
32 Ovesen, L, Sorensen, M, Hannibal, J, Allingstrup, L. Electrical taste detection and chemical smell detection thresholds in patients with cancer. Cancer 1991;68:2260–53.0.CO;2-W>CrossRefGoogle ScholarPubMed
33 Yakirevitch, A, Talmi, YP, Baram, Y, Weitzen, R, Pfeffer, MR. Effects of cisplatin on olfactory function in cancer patients. Br J Cancer 2005;92:1611–13Google Scholar
34 Nguyen, DT, Nguyen-Thi, PL, Jankowski, R. How does measured olfactory function correlate with self-ratings of the sense of smell in patients with nasal polyposis? Laryngoscope 2012;122:947–52Google Scholar