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Ototoxicity of ear drops in patients suffering from chronic otitis media*

Published online by Cambridge University Press:  29 June 2007

L. Podoshin ,
M. Fradis  and
J. Ben David
L. Podoshin*
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
M. Fradis
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
J. Ben David
Affiliation:
From the Department of Otolaryngology, Haifa Medical Center (Rothschild), Faculty of Medicine, Tehnion-Israel Institute of Technology, Haifa, Israel.
*
Correspondence and reprints address: Prof. L. Podoshin, M.D., Dept of Otolaryngology, The Haifa Medical Center (Rothschild), P.O. Box 4940, Haifa 31048, Israel.
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Abstract

The sensorineural hearing loss in 150 patients with chronic otitis media who were treated in the Haifa Medical Center (Rothschild) during a ten year period was studied. There were 124 patients treated with a mixture containing neomycin, polymyxin B and dexamethasone and a control group of 26 patients with dexamethasone only.

All patients were followed up for a period of 1–2 years. Patients with hearing loss due to factors such as previous ear surgery, family history, exposure to noise etc., have been excluded.

The conclusions reached were that there is a relationship between the period of disease and the sensorineural hearing loss and that the local treatment with a mixture containing neomycin + polymyxin B appears to contribute to the worsening of the sensorineural hearing loss in patients with chronic otitis media.

Our numbers are small and further studies must be done, but the fact that currently used ear drops may produce a sensorineural hearing loss should not be ignored.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 1 , January 1989 , pp. 46 - 50
Copyright
Copyright © JLO (1984) Limited 1989

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Footnotes

*

Presented at the XI'I World Congress of Otolaryngology, May 1985, Miama Beach, Florida.

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