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Primary small cell carcinoma of lacrimal sac: case report and literature review

  • T Goto (a1) (a2), N Bandoh (a1) (a2), T Nagato (a1), M Takahara (a1), Y Harabuchi (a1), Y Tokusashi (a3) and N Miyokawa (a3)
  • DOI:
  • Published online: 23 April 2010

We present the first reported case of primary small cell carcinoma of the lacrimal sac.

Case report:

A 67-year-old Japanese woman was referred to our department with a two-month history of left medial canthal swelling, epiphora and occasional nasal bleeding. Nasal endoscopy revealed a readily bleeding tumour in the left inferior meatus. Computed tomography and magnetic resonance imaging scans demonstrated that the tumour was mainly located in the left lacrimal sac. Histopathological studies of a biopsy specimen revealed small cell carcinoma. The patient was treated with four cycles of chemotherapy consisting of cisplatin and etoposide, in combination with radiotherapy. There was no evidence of recurrence or metastasis for five years.


Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and to have a poor prognosis. We report a case of primary small cell carcinoma of the lacrimal sac successfully treated with chemo-radiotherapy.

Corresponding author
Address for correspondence: Dr Nobuyuki Bandoh, Head and Neck Cancer Center, Hokuto Hospital, Inadacho Kisen 7-5, Obihiro, Hokkaido, 080-0833, Japan. Fax: +81 155 47 3094 E-mail:
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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