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Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients

Published online by Cambridge University Press:  16 December 2015

H S Lee ,
C Park ,
S W Kim ,
J W Song ,
B K Chun ,
T J Park ,
J C Hong  and
K D Lee
H S Lee
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea
C Park
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea
S W Kim
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea
J W Song
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea
B K Chun
Affiliation:
Department of Pathology, Kosin University College of Medicine, Busan, Korea
T J Park
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Maryknoll Medical Center, Busan, Korea
J C Hong
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea
K D Lee*
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea
*
Address for correspondence: Dr K D Lee, Department of Otolaryngology, Kosin University Gospel Hospital Am-Nam Dong 34, Seo-Gu, Busan 602–702, South Korea Fax: +82 51 245 8539 E-mail: kdlee59@gmail.com
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Abstract

Objective:

This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients.

Method:

A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted.

Results:

A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733).

Conclusion:

Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.

Keywords

Thyroid NeoplasmsLymph NodesLymphatic MetastasisPathology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 3 , March 2016 , pp. 302 - 308
Copyright
Copyright © JLO (1984) Limited 2015 

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