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Rhabdomyosarcoma of the trachea: first reported case treated with proton beam therapy

  • R Exley (a1), J M Bernstein (a1), B Brennan (a2) and M P Rothera (a3)

We report a case of rhabdomyosarcoma of the trachea in a 14-month-old child, and we present the first reported use of proton beam therapy for this tumour.

Case report:

A 14-month-old girl presented acutely with a seven-day history of biphasic stridor. Emergency endoscopic debulking of a posterior tracheal mass was undertaken. Histological examination revealed an embryonal rhabdomyosarcoma with anaplasia. Multimodality therapy with surgery and chemotherapy was administered in the UK, and proton beam therapy in the USA.


Only three cases of rhabdomyosarcoma of the trachea have previously been reported in the world literature. This is the first reported case of treatment of this tumour with proton beam therapy. Compared with conventional radiotherapy, proton beam therapy may confer improved long-term outcome in children, with benefits including reduced irradiation of the spinal cord.

Corresponding author
Address for correspondence: Mr Jonathan M Bernstein, Clinical Research Fellow, Head and Neck Surgical Oncology, Radiotherapy Related Research, 2nd Floor, Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK Fax: +44 (0)161 446 8111 E-mail:
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Presented at the 141st Semon Club Meeting, 2 June 2011, London, UK

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2 JP Vaccani , V Forte , AL de Jong , G Taylor . Ewing's sarcoma of the head and neck in children. Int J Pediatr Otorhinolaryngol 1999;48:209–16

3 P Gradoni , D Giordano , G Oretti , M Fantoni , T Ferri . The role of surgery in children with head and neck rhabdomyosarcoma and Ewing's sarcoma. Surg Oncol 2010;19:e103–9

4 SS Donaldson . The value of adjuvant chemotherapy in the management of sarcomas in children. Cancer 1985;55:2184–97

7 RL Brown , RG Azizkhan . Pediatric head and neck lesions. Pediatr Clin North Am 1998;45:889905

8 C Weber . Investigation of hypertrophic tongue and comments on striated muscle fibres [in German]. Arch Pathol Anat 1854;7:115–21

9 JM Dodd-o , KF Wieneke , PM Rosman . rhabdomyosarcoma Laryngeal . Case report and literature review. Cancer 1987;59:1012–18

10 J Hicks , C Flaitz . Rhabdomyosarcoma of the head and neck in children. Oral Oncol 2002;38:450–9

12 S Larsson , V Lepore , G Cardillo , T Seidal . Primary tracheal rhabdomyosarcoma. Case report. Scand J Thorac Cardiovasc Surg 1989;23:293–5

14 WA Newton Jr, EA Gehan , BL Webber , HB Marsden , AJ van Unnik , AB Hamoudi Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification – an Intergroup Rhabdomyosarcoma Study. Cancer 1995;76:1073–85

16 JH Simon , AC Paulino , RB Smith , JM Buatti . Prognostic factors in head and neck rhabdomyosarcoma. Head Neck 2002;24:468–73

18 WP Levin , H Kooy , JS Loeffler , TF DeLaney . Proton beam therapy. Br J Cancer 2005;93:849–54

19 R Miralbell , A Lomax , L Cella , U Schneider . Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors. Int J Radiat Oncol Biol Phys 2002;54:824–9

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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