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    Song, Si-Youn Woo, Hyun-Jae Bae, Chang Hoon Kim, Yong-Woon and Kim, Yong-Dae 2010. Expression of leptin receptor in nasal polyps: Leptin as a mucosecretagogue. The Laryngoscope, p. NA.


    Taildeman, Jasmien Demetter, Pieter Rottiers, Isabelle Holtappels, Gabriele Bachert, Claus Cuvelier, Claude A and Pérez-Novo, Claudina A 2010. Identification of the nasal mucosa as a new target for leptin action. Histopathology, Vol. 56, Issue. 6, p. 789.


    Woo, Hyun-Jae Yoo, Woo Jong Bae, Chang Hoon Song, Si-Youn Kim, Yong-Woon Park, So-Young and Kim, Yong-Dae 2010. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. Experimental Lung Research, Vol. 36, Issue. 5, p. 262.


    Taildeman, Jasmien Pérez-Novo, Claudina A. Rottiers, Isabelle Ferdinande, Liesbeth Waeytens, Anouk De Colvenaer, Veerle Bachert, Claus Demetter, Pieter Waelput, Wim Braet, Katleen and Cuvelier, Claude A. 2009. Human mast cells express leptin and leptin receptors. Histochemistry and Cell Biology, Vol. 131, Issue. 6, p. 703.


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Serum leptin levels in patients with nasal polyposis

  • M Guven (a1), Y Bulut (a2), I Aladag (a1), K Yelken (a1) and H Erdoğan (a3)
  • DOI: http://dx.doi.org/10.1017/S002221510700967X
  • Published online: 01 June 2008
Abstract
AbstractBackground:

Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. The aetiopathogenetic mechanisms of nasal polyp formation are still unclear.

Objectives:

The aim of this study was to investigate the serum leptin levels in patients with nasal polyposis.

Design:

A randomised, prospective study was performed of 28 adult patients with nasal polyposis and 22 control subjects of a similar age, sex and body mass index.

Results:

Serum leptin levels were 12.10 ± 9.39 ng/ml in the nasal polyposis patients and 6.17 ± 7.68 ng/ml in the controls. A significant difference (p = 0.021) was observed in the mean serum leptin levels between nasal polyposis patients and controls.

Conclusion:

Serum leptin levels were found to be significantly higher in patients with nasal polyposis. Leptin, apart from its primary role in the regulation of body weight and energy expenditure, may have a role in the inflammatory response of nasal polyposis.

Copyright
Corresponding author
Address for correspondence: Dr Mehmet Guven, Gaziosmanpasa University Medical Faculty, Department of Otorhinolaryngology, 60100 Tokat, Turkey. Fax: +9 0356213 31 79 E-mail: guvenmehmet28@yahoo.com
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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