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Sinonasal mucosal melanoma: retrospective survival study of 25 patients

  • C Vandenhende (a1), X Leroy (a2), D Chevalier (a1) and G Mortuaire (a1)



To determine potential prognostic factors for survival in patients with mucosal malignant melanoma of the sinonasal tract.


Patients managed between 1991 and 2008 were assessed retrospectively. The seventh edition Union for International Cancer Control (7th UICC) tumour-node-metastasis classification was used for tumour staging. Kaplan–Meier and log rank tests were used for survival analysis.


Twenty-five patients were studied (six were tumour stage three, eight tumour stage four(a) and 11 tumour stage four(b)). Surgery was performed on 23 patients (92 per cent). Fifteen received post-operative radiotherapy. Mean follow up was 31.3 months (range, two to 99 months). Three-year disease-free survival was improved in patients with stage four tumour arising from the nasal fossa, versus other sites, and in those with stage four tumour treated with surgery plus adjuvant radiotherapy, versus other treatments.


Patients with melanoma of the nasal cavity have very poor survival rates. Treatment is still based on adequate surgical resection with safe margins. In this study, post-operative radiotherapy improved local control only for stage four tumours.


Corresponding author

Address for correspondence: Dr Geoffrey Mortuaire, Service d'ORL de Chirurgie Cervico-faciale, Pr Chevalier, CHRU Lille, 59000, France Fax: +33 320446220 E-mail:


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1Enée, V, Houliat, T, Truilhé, Y, Darrouzet V, Stoll D. Malignant melanoma of the nasosinal mucosa [in French]. Retrospective study a propos of 20 cases. Rev Laryngol Otol Rhinol (Bord) 2000;121:243–50
2Huang, SF, Liao, CT, Kan, CR, Chen, IH. Primary mucosal melanoma of the nasal cavity and paranasal sinuses: 12 years of experience. J Otolaryngol 2007;36:124–9
3Ganly, I, Patel, SG, Singh, B, Kraus, DH, Bridger, PG, Cantu, G et al. Craniofacial resection for malignant melanoma of the skull base: report of an international collaborative study. Arch Otolaryngol Head Neck Surg 2006;132:73–8
4Bhattacharyya, N. Cancer of the nasal cavity: survival and factors influencing prognosis. Arch Otolaryngol Head Neck Surg 2002;128:1079–83
5Owens, JM, Roberts, DB, Myers, JN. The role of postoperative adjuvant radiation therapy in the treatment of mucosal melanomas of the head and neck region. Arch Otolaryngol Head Neck Surg 2003;129:864–8
6Prasad, ML, Busam, KJ, Patel, SG, Hoshaw-Woodard, S, Shah, JP, Huvos, AG. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 2003;127:9971002
7Lee, SP, Shimizu, KT, Tran, LM, Juillard, G, Calcaterra, TC. Mucosal melanoma of the head and neck: the impact of local control on survival. Laryngoscope 1994;104:121–6
8Pomar Blanco, P, San Román Carbajo, J, Bouso Montero, M, Martín Villares, C, Fernández Pello, M, Tapia Risueño, M. Sinonasal mucosal melanoma [in Spanish]. An Otorrinolaringol Ibero Am 2007;34:349–58
9Trapp, TK, Fu, YS, Calcaterra, TC. Melanoma of the nasal and paranasal sinus mucosa. Arch Otolaryngol Head Neck Surg 1987;113:1086–9
10Dauer, EH, Lewis, JE, Rohlinger, AL, Weaver, AL, Olsen, KD. Sinonasal melanoma: a clinicopathologic review of 61 cases. Otolaryngol Head Neck Surg 2008;138:347–52
11Meleti, M, Leemans, CR, de Bree, R, Vescovi, P, Sesenna, E, van der Waal, I. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck 2008;30:1543–51
12Temam, S, Mamelle, G, Marandas, P, Wibault, P, Avril, MF, Janot, F et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–19
13Stárek, I, Koranda, P, Benes, P. Sentinel lymph node biopsy: a new perspective in head and neck mucosal melanoma? Melanoma Res 2006;16:423–7
14Lund, VJ, Howard, DJ, Harding, L, Wei, WI. Management options and survival in malignant melanoma of the sinonasal mucosa. Laryngoscope 1999;109:208–11
15Mendenhall, WM, Amdur, RJ, Hinerman, RW, Werning, JW, Villaret, DB, Mendenhall, NP. Head and neck mucosal melanoma. Am J Clin Oncol 2005;28:626–30
16Wu, AJ, Gomez, J, Zhung, JE, Chan, K, Gomez, DR, Wolden, SL et al. Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol 2010;33:281–5
17Wagner, M, Morris, CG, Werning, JW, Mendenhall, WM. Mucosal melanoma of the head and neck. Am J Clin Oncol 2008;31:43–8
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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