Skip to main content

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
Cancel
×
×
Home
  • Home
Article
  • Cited by 5
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Mitsudo, Kenji Hayashi, Yuichiro Minamiyama, Shuhei Ohashi, Nobuhide Iida, Masaki Iwai, Toshinori Oguri, Senri Koizumi, Toshiyuki Kioi, Mitomu Hirota, Makoto Koike, Izumi Hata, Masaharu and Tohnai, Iwai 2018. Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases. Oral Oncology, Vol. 79, Issue. , p. 71.
    Dissanayake, Upul 2017. Malignancy grading of invasive fronts of oral squamous cell carcinomas. Translational Research in Oral Oncology, Vol. 2, Issue. , p. 2057178X1770887.
    Okuyemi, Oluwafunmilola T. Piccirillo, Jay F. and Spitznagel, Edward 2014. TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival. Head & Neck, p. n/a.
    Goldstein, David P. Bachar, Gideon Y. Lea, Jane Shrime, Mark G. Patel, Rajan S. Gullane, Patrick J. Brown, Dale H. Gilbert, Ralph W. Kim, John Waldron, Jonathan Perez-Ordonez, Bayardo Davis, Aileen M. Cheng, Lu Xu, Wei and Irish, Jonathan C. 2013. Outcomes of squamous cell cancer of the oral tongue managed at the princess margaret hospital. Head & Neck, Vol. 35, Issue. 5, p. 632.
    Lin, Chien-Yu Wang, Hung-Ming Kang, Chung-Jan Lee, Li-Yu Huang, Shiang-Fu Fan, Kang-Hsing Chen, Eric Yen-Chao Chen, I-How Liao, Chun-Ta and Chang, Joseph Tung-Chieh 2010. Primary Tumor Site as a Predictor of Treatment Outcome for Definitive Radiotherapy of Advanced-Stage Oral Cavity Cancers. International Journal of Radiation Oncology*Biology*Physics, Vol. 78, Issue. 4, p. 1011.
    ×
  • Get access
    Add to cart USD35.00
    Check if you have access via personal or institutional login
    Log in Register Recommend to librarian

Squamous cell carcinoma of the oral tongue: a 25-year, single institution experience

  • M S Mosleh-Shirazi (a1) (a2), M Mohammadianpanah (a1) and M A Mosleh-Shirazi (a1)
Abstract
Aim:

To report the characteristics, prognostic factors and treatment outcomes of 102 patients with squamous cell carcinoma of the oral tongue treated and followed up at a single institution over a 25-year period.

Patients and methods:

This retrospective study was carried out by auditing the medical records of 102 patients diagnosed with squamous cell carcinoma of the oral tongue and treated at our institution between 1982 and 2007. Patient follow up ranged from nine to 310 months (median 35 months). Fifty per cent of the patients were treated with surgery followed by a combination of chemotherapy and radiotherapy (43.1 per cent received concurrent chemoradiation and 6.9 per cent received sequential chemotherapy and radiotherapy), whereas 29.4 per cent received surgery followed by adjuvant radiotherapy alone. The remaining patients (20.6 per cent) did not undergo surgery and were treated with definitive radiotherapy with or without chemotherapy.

Results:

There were 48 men and 54 women. The age at presentation was 19–85 years (median 57 years). The peak incidence was observed between 60 and 70 years. Resection margins were clear in 75 per cent of patients and involved in 25 per cent. Stage I disease was found in 11.8 per cent of patients, stage II in 34.3 per cent, stage III in 22.5 per cent and stage IV in 31.4 per cent. The five-year disease-free survival and overall survival were 65.7 and 72.5 per cent, respectively. Thirty-five patients suffered recurrence after treatment, 74.0 per cent of them at the site of initial cervical nodal involvement. Univariate analysis for overall survival revealed the following as prognostic factors: treatment schedule (surgical vs non-surgical; p < 0.001); age (<60 years vs ≥60 years; p = 0.038); extent of cervical lymph node involvement (p = 0.015); primary tumour stage (p < 0.001); node stage (p = 0.034); and disease stage (p = 0.013). However, on multivariate analysis, only non-surgical treatment (p = 0.001) and advanced disease stage (p = 0.05) were found to have a negative influence on survival.

Conclusions:

Our limited data suggest that, in Iran, squamous cell carcinoma of the oral tongue tends to present at a locally advanced stage, with a high frequency of locoregional failure and a poor outcome. Combined modality therapy should be considered for the majority of patients with squamous cell carcinoma of the tongue.

Copyright
COPYRIGHT: © JLO (1984) Limited 2008
Corresponding author
Address for correspondence: Dr Mohammad Mohammadianpanah, Department of Radiation Oncology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz 71936-13311, Iran. Fax: +98 711 6260135 E-mail: mohpanah@sums.ac.ir
References
Hide All
1 Prince, S, Bailey, BM. Squamous carcinoma of the tongue: review. Br J Oral Maxillofac Surg 1999;37:164–74
2 Lam, L, Logan, RM, Luke, C, Rees, GL. Retrospective study of survival and treatment pattern in a cohort of patients with oral and oropharyngeal tongue cancers from 1987 to 2004. Oral Oncol 2007;43:150–8
3 Zwetyenga, N, Majoufre-Lefebvre, C, Siberchicot, F, Demeaux, H, Pinsolle, J. Squamous-cell carcinoma of the tongue: treatment results and prognosis [in French]. Rev Stomatol Chir Maxillofac 2003;104:10–17
4 Stelow, EB, Mills, SE. Squamous cell carcinoma variants of the upper aerodigestive tract. Am J Clin Pathol 2005;124 Suppl:S96–109
5 Lee, CC, Ho, HC, Chen, HL, Hsiao, SH, Hwang, JH, Hung, SK. Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis. Acta Otolaryngol 2007;127:1214–17
6 El-Husseiny, G, Kandil, A, Jamshed, A, Khafaga, Y, Saleem, M, Allam, A et al. Squamous cell carcinoma of the oral tongue: an analysis of prognostic factors. Br J Oral Maxillofac Surg 2000;38:193–9
7 Davidson, BJ, Root, WA, Trock, BJ. Age and survival from squamous cell carcinoma of the oral tongue. Head Neck 2001;23:273–9
8 Gorsky, M, Epstein, JB, Oakley, C, Le, ND, Hay, J, Stevenson-Moore, P. Carcinoma of the tongue: a case series analysis of clinical presentation, risk factors, staging, and outcome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98:546–52
9 Atula, S, Grenman, R, Laippala, P, Syrjanen, S. Cancer of the tongue in patients younger than 40 years. A distinct entity? Arch Otolaryngol Head Neck Surg 1996;122:1313–19
10 Davidson, BJ, Root, WA, Trock, BJ. Age and survival from squamous cell carcinoma of the oral tongue. Head Neck 2001;23:273–9
11 Funk, GF, Karnell, LH, Robinson, RA, Zhen, WK, Trask, DK, Hoffman, HT. Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck 2002;24:165–80
12 Mäkitie, AA, Koivunen, P, Keski-Säntti, H, Törnwall, J, Pukkila, M, Laranne, J et al. Oral tongue carcinoma and its treatment in Finland. Eur Arch Otorhinolaryngol 2007;264:263–7
13 Kuriakose, M, Sankaraarayanan, M, Nair, MK, Cherian, T, Sugar, AW, Scully, C et al. Comparison of oral squamous cell carcinoma in younger and older patients in India. Eur J Cancer B Oral Oncol 1992;28:113–20
14 Schantz, SP, Byers, RM, Goepfert, H, Shallenberger, RC, Beddingfield, N. The implication of tobacco use in the young adult with head and neck cancer. Cancer 1988;62:1374–80
15 Bell, RB, Kademani, D, Homer, L, Dierks, EJ, Potter, BE. Tongue cancer: is there a difference in survival compared with other subsites in the oral cavity? J Oral Maxillofac Surg 2007;65:229–36
16 Tan, EH, Adelstein, DJ, Droughton, ML, Van Kirk, MA, Lavertu, P. Squamous cell head and neck cancer in nonsmokers. Am J Clin Oncol 1997;20:146–50
17 Burzynski, NJ, Flynn, MB, Faller, NM, Ragsdale, TL. Squamous cell carcinoma of the upper aerodigestive tract in patients 40 years of age and younger. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1992;74:404–8
18 Lo, WL, Kao, SY, Chi, LY, Wong, YK, Chang, RC. Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg 2003;61:751–8
19 Chen, YK, Huang, HC, Lin, LM, Lin, CC. Primary oral squamous cell carcinoma: an analysis of 703 cases in southern Taiwan. Oral Oncol 1999;35:173–9
20 Sargeran, K, Murtomaa, H, Safavi, SM, Vehkalahti, M, Teronen, O. Malignant oral tumors in Iran: ten-year analysis on patient and tumor characteristics of 1042 patients in Tehran. J Craniofac Surg 2006;17:1230–3
21 Sargeran, K, Murtomaa, H, Safavi, SM, Vehkalahti, M, Teronen, O. Survival after diagnosis of cancer of the oral cavity. Br J Oral Maxillofac Surg 2008;46:187–91
22 Finlay, PM, Dawson, F, Robertson, AG, Soutar, DS. An evaluation of functional outcome after surgery and radiotherapy for intraoral cancer. Br J Oral Maxillofac Surg 1992;30:14–17
23 Zelefski, MJ, Harrison, LB, Armstrong, JG. Long term treatment results of postoperative radiation therapy for advanced stage oropharyngeal carcinoma. Cancer 1992;70:2388–95
24 Franceschi, D, Gupta, R, Spiro, RH, Shah, JP. Improved survival in the treatment of squamous carcinoma of the oral tongue. Am J Surg 1993;166:360–5
25 Fein, DA, Mendenhall, WM, Parsons, JT, McCarty, PJ, Stringer, SP, Million, RR et al. Carcinoma of the oral tongue: a comparison of results and complications of treatment with radiotherapy and/or surgery. Head Neck 1994;16:358–65
26 Sessions, DG, Spector, GJ, Lenox, J, Haughey, B, Chao, C, Marks, J. Analysis of treatment results for oral tongue cancer. Laryngoscope 2002;112:616–25
27 Pernot, M, Malissard, L, Hoffstetter, S, Luporsi, E, Peiffert, D, Aletti, P et al. The study of tumoral, radiobiological, and general health factors that influence results and complications in a series of 448 oral tongue carcinomas treated exclusively by irradiation. Int J Radiat Oncol Biol Phys 1994;29:673–9
28 Shah, JP, Andersen, PE. Evolving role of modifications in neck dissection for oral squamous carcinoma. Br J Maxillofac Surg 1995;33:3–8
29 Friedlander, PL, Schantz, SP, Shaha, AR, Yu, G, Shah, JP. Squamous cell carcinoma of the tongue in young patients. Head Neck 1998;20:363–8
30 Schrijvers, AHGJ. MAb U36, a novel monoclonal antibody successful in immunotargeting of squamous cell carcinoma of the head and neck. Cancer Res 1993;53:4383–90
31 Vargas, H, Pitman, KT, Johnson, JT, Galati, LT. More aggressive behavior of squamous cell carcinoma of the anterior tongue in young women. Laryngoscope 2000;110:1623–6
32 Popovtzer, A, Shpitzer, T, Bahar, G, Marshak, G, Ulanovski, D, Feinmesser, R. Squamous cell carcinoma of the oral tongue in young patients. Laryngoscope 2004;114:915–17
33 Sasaki, T, Moles, DR, Imai, Y, Speight, PM. Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age. J Oral Pathol Med 2005;34:129–33
34 Lim, YC, Lee, JS, Koo, BS, Kim, SH, Kim, YH, Choi, EC. Treatment of contralateral N0 neck in early squamous cell carcinoma of the oral tongue: elective neck dissection versus observation. Laryngoscope 2006;116:461–5
35 Kurita, H, Koike, T, Narikawa, J, Sakai, H, Nakatsuka, A, Uehara, S et al. Clinical predictors for contralateral neck lymph node metastasis from unilateral squamous cell carcinoma in the oral cavity. Oral Oncol 2004;40:898–903
36 Deng, LF, Chen, FJ, Zeng, ZY, Wei, MW, Yang, AK, Zhang, Q. Neck management in oral tongue squamous cell carcinoma of stage I: a report of 95 cases [in Chinese]. Ai Zheng 2005;24:204–7
37 Wolfensberger, M, Zbaeren, P, Dulguerov, P, Müller, W, Arnoiux, A, Schmid, S. Surgical treatment of early oral carcinoma – results of a prospective controlled multicenter study. Head Neck 2001;23:525–30
38 Schiff, BA, Roberts, DB, El-Naggar, A, Garden, AS, Myers, JN. Selective vs modified radical neck dissection and postoperative radiotherapy vs observation in the treatment of squamous cell carcinoma of the oral tongue. Arch Otolaryngol Head Neck Surg 2005;131:874–8
39 Woolgar, JA, Rogers, S, West, CR, Errington, RD, Brown, JS, Vaughan, ED. Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection. Oral Oncol 1999;35:257–65
40 Malone, JP, Stephens, JA, Grecula, JC, Rhoades, CA, Ghaheri, BA, Schuller, DE. Disease control, survival, and functional outcome after multimodal treatment for advanced-stage tongue base cancer. Head Neck 2004;26:561–72
41 Fan, KH, Lin, CY, Kang, CJ, Huang, SF, Wang, HM, Chen, EY et al. Combined-modality treatment for advanced oral tongue squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2007;67:453–61
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *

CAPTCHA *

Skip to the audio challenge
×

Keywords:

Metrics

Full text views

Total number of HTML views: 2
Total number of PDF views: 15 *
Loading metrics...

Abstract views

Total abstract views: 148 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 12th June 2018. This data will be updated every 24 hours.

Cancel
Confirm
×