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Surgical and interventional radiological management of adult epistaxis: systematic review

Published online by Cambridge University Press:  27 December 2017

C Swords*
Affiliation:
Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK
A Patel
Affiliation:
Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK
M E Smith
Affiliation:
Department of Otolaryngology, Addenbrooke's Hospital, Cambridge, UK
R J Williams
Affiliation:
Institute of Naval Medicine, Gosport, UK
I Kuhn
Affiliation:
University of Cambridge School of Clinical Medicine, UK
C Hopkins
Affiliation:
Department of Otolaryngology, Guy's and St Thomas’ Hospital, London, UK
*
Address for correspondence: Miss Chloe Swords, Department of Otolaryngology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK E-mail: chloeswords@doctors.org.uk

Abstract

Background:

There is variation regarding the use of surgery and interventional radiological techniques in the management of epistaxis. This review evaluates the effectiveness of surgical artery ligation compared to direct treatments (nasal packing, cautery), and that of embolisation compared to direct treatments and surgery.

Method:

A systematic review of the literature was performed using a standardised published methodology and custom database search strategy.

Results:

Thirty-seven studies were identified relating to surgery, and 34 articles relating to interventional radiology. For patients with refractory epistaxis, endoscopic sphenopalatine artery ligation had the most favourable adverse effect profile and success rate compared to other forms of surgical artery ligation. Endoscopic sphenopalatine artery ligation and embolisation had similar success rates (73–100 per cent and 75–92 per cent, respectively), although embolisation was associated with more serious adverse effects (risk of stroke, 1.1–1.5 per cent). No articles directly compared the two techniques.

Conclusion:

Trials comparing endoscopic sphenopalatine artery ligation to embolisation are required to better evaluate the clinical and economic effects of intervention in epistaxis.

Type
Review Articles
Copyright
Copyright © JLO (1984) Limited 2017 

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References

1 Tan, LK, Calhoun, KH. Epistaxis. Med Clin North Am 1999;83:4356 Google Scholar
2 Viducich, RA, Blanda, MP, Gerson, LW. Posterior epistaxis: clinical features and acute complications. Ann Emerg Med 1995;25:592–6Google Scholar
3 Jindal, G, Gemmete, J, Gandhi, D. Interventional neuroradiology applications in otolaryngology, head and neck surgery. Otolaryngol Clin North Am 2012;45:1423–49Google Scholar
4 Sokoloff, J, Wickbom, I, McDonald, D, Brahme, F, Goergen, TC, Goldberger, LE. Therapeutic percutaneous embolization in intractable epistaxis. Radiology 1974;111:285–7Google Scholar
5 Khan, M, Conroy, K, Ubayasiri, K, Constable, J, Smith, ME, Williams, RJ et al. Initial assessment in the management of adult epistaxis: systematic review. J Laryngol Otol. In pressGoogle Scholar
6 Moshaver, A, Harris, JR, Liu, R, Diamond, C, Seikaly, H. Early operative intervention versus conventional treatment in epistaxis: randomized prospective trial. J Otolaryngol 2004;33:185–8Google Scholar
7 Asanau, A, Timoshenko, AP, Vercherin, P, Martin, C, Prades, JM. Sphenopalatine and anterior ethmoidal artery ligation for severe epistaxis. Ann Otol Rhinol Laryngol 2009;118:639–44Google Scholar
8 Cullen, MM, Tami, TA. Comparison of internal maxillary artery ligation versus embolization for refractory posterior epistaxis. Otolaryngol Head Neck Surg 1998;118:636–42Google ScholarPubMed
9 della Faille, D, Schmelzer, B, Vidts, G, Kunnen, J, Cammaert, T, Katz, S et al. Posterior epistaxis: our experience with transantral ligation and embolisation. Acta Otorhinolaryngol Belg 1997;51:167–71Google Scholar
10 Cumberworth, VL, Narula, AA, Bradley, PJ. Prospective study of two management strategies for epistaxis. J R Coll Surg Edinb 1991;36:259–60Google Scholar
11 Klotz, DA, Winkle, MR, Richmon, J, Hengerer, AS. Surgical management of posterior epistaxis: a changing paradigm. Laryngoscope 2002;112:1577–82Google Scholar
12 McDonald, TJ, Pearson, BW. Follow-up on maxillary artery ligation for epistaxis. Arch Otolaryngol 1980;106:635–8Google Scholar
13 Schaitkin, B, Strauss, M, Houck, JR. Epistaxis: medical versus surgical therapy: a comparison of efficacy, complications, and economic considerations. Laryngoscope 1987;97:1392–6Google Scholar
14 Small, M, Maran, AG. Epistaxis and arterial ligation. J Laryngol Otol 1984;98:281–4Google Scholar
15 Srinivasan, V, Sherman, IW, O'Sullivan, G. Surgical management of intractable epistaxis: audit of results. J Laryngol Otol 2000;114:697700 Google Scholar
16 Strong, EB, Bell, DA, Johnson, LP, Jacobs, JM. Intractable epistaxis: transantral ligation vs. embolization: efficacy review and cost analysis. Otolaryngol Head Neck Surg 1995;113:674–8Google Scholar
17 Umapathy, N, Quadri, A, Skinner, DW. Persistent epistaxis: what is the best practice? Rhinology 2005;43:305–8Google Scholar
18 Villwock, JA, Goyal, P. Early versus delayed treatment of primary epistaxis in the United States. Int Forum Allergy Rhinol 2014;4:6975 Google Scholar
19 Wehrli, M, Lieberherr, U, Valavanis, A. Superselective embolization for intractable epistaxis: experiences with 19 patients. Clin Otolaryngol Allied Sci 1988;13:415–20Google Scholar
20 Abdelkader, M, Leong, SC, White, PS. Endoscopic control of the sphenopalatine artery for epistaxis: long-term results. J Laryngol Otol 2007;121:759–62Google Scholar
21 Gandomi, B, Arzaghi, MH, Khademi, B, Rafatbakhsh, M. Endoscopic cauterization of the sphenopalatine artery to control severe and recurrent posterior epistaxis. Iran J Otorhinolaryngol 2013;25:147–54Google Scholar
22 Gede, LL, Aanaes, K, Collatz, H, Larsen, PL, von Buchwald, C. National long-lasting effect of endonasal endoscopic sphenopalatine artery clipping for epistaxis. Acta Otolaryngol 2013;133:744–8Google Scholar
23 Eladl, HM, Elmorsy, SM, Khafagy, YW. Endoscopic devascularisation of sphenopalatine bundle in intractable posterior epistaxis: technique, efficacy and safety. J Laryngol Otol 2011;125:1136–40Google Scholar
24 George, A, Smatanova, K, Joshi, H, Jervis, S, Oluwole, M. Sphenopalatine, anterior ethmoid and internal maxillary artery intervention in the management of refractory epistaxis: their efficacy in 25 patients. Clin Otolaryngol 2012;37:321–5Google Scholar
25 Harvinder, S, Rosalind, S, Gurdeep, S. Endoscopic cauterization of the sphenopalatine artery in persistent epistaxis. Med J Malaysia 2008;63:377–8Google Scholar
26 Howe, DJ, Wazir, U, Skinner, DW. Outcomes of endoscopic sphenopalatine artery ligation for epistaxis: a five-year series from a single institution. Ear Nose Throat J 2012;91:70–2Google Scholar
27 Minni, A, Dragonetti, A, Gera, R, Barbaro, M, Magliulo, G, Filipo, R. Endoscopic management of recurrent epistaxis: the experience of two metropolitan hospitals in Italy. Acta Otolaryngol 2010;130:1048–52Google Scholar
28 Nouraei, SA, Maani, T, Hajioff, D, Saleh, HA, Mackay, IS. Outcome of endoscopic sphenopalatine artery occlusion for intractable epistaxis: a 10-year experience. Laryngoscope 2007;117:1452–6Google Scholar
29 O'Flynn, PE, Shadaba, A. Management of posterior epistaxis by endoscopic clipping of the sphenopalatine artery. Clin Otolaryngol Allied Sci 2000;25:374–7Google Scholar
30 Rockey, JG, Anand, R. A critical audit of the surgical management of intractable epistaxis using sphenopalatine artery ligation/diathermy. Rhinology 2002;40:147–9Google Scholar
31 Wiorowski, M, Schultz, P, Perrot, JB, Gentine, A, Debry, C. Indications and results of cauterization by endoscopic approach of the sphenopalatine artery in severe posterior epistaxis. Auris Nasus Larynx 2004;31:131–3Google Scholar
32 Wormald, PJ, Wee, DT, van Hasselt, CA. Endoscopic ligation of the sphenopalatine artery for refractory posterior epistaxis. Am J Rhinol 2000;14:261–4Google Scholar
33 Sharp, HR, Rowe-Jones, JM, Biring, GS, Mackay, IS. Endoscopic ligation or diathermy of the sphenopalatine artery in persistent epistaxis. J Laryngol Otol 1997;111:1047–50Google Scholar
34 Tsai, HM, Shu, CH. Transnasal sphenopalatine artery electrocautery for posterior epistaxis. Zhonghua Yi Xue Za Zhi (Taipei) 2002;65:529–33Google Scholar
35 Snyderman, CH, Carrau, RL. Endoscopic ligation of the sphenopalatine artery for epistaxis. Oper Tech Otolaryngol Head Neck Surg 1997;8:85–9Google Scholar
36 Ellis, DA, LeLiever, WC. Indications for internal maxillary artery ligation in the treatment of epistaxis. J Otolaryngol 1980;9:228–32Google Scholar
37 Metson, R, Lane, R. Internal maxillary artery ligation for epistaxis: an analysis of failures. Laryngoscope 1988;98:760–4CrossRefGoogle ScholarPubMed
38 Nair, KK. Transantral ligation of the internal maxillary artery. Laryngoscope 1982;92:1060–3Google Scholar
39 Premachandra, DJ, Sergeant, RJ. Dominant maxillary artery as a cause of failure in maxillary artery ligation for posterior epistaxis. Clin Otolaryngol Allied Sci 1993;18:42–7Google Scholar
40 Felippu, A, Mora, R, Guastini, L. Endoscopic transnasal cauterization of the anterior ethmoidal artery. Acta Otolaryngol 2011;131:1074–8Google Scholar
41 Rulon, JT. External carotid artery ligation for the management of severe posterior epistaxis. Trans Pac Coast Otoophthalmol Soc Annu Meet 1968;49:8191 Google Scholar
42 Waldron, J, Stafford, N. Ligation of the external carotid artery for severe epistaxis. J Otolaryngol 1992;21:249–51Google Scholar
43 Villwock, JA, Jones, K. Recent trends in epistaxis management in the United States: 2008-2010. JAMA Otolaryngol Head Neck Surg 2013;139:1279–84Google Scholar
44 Baloch, MA, Awan, MS, Nabeel, H. Angioembolization in intractable epistaxis – a tertiary care experience. J Pak Med Assoc 2012;62:254–6Google Scholar
45 Breda, SD, Choi, IS, Persky, MS, Weiss, M. Embolization in the treatment of epistaxis after failure of internal maxillary artery ligation. Laryngoscope 1989;99:809–13Google Scholar
46 Christensen, NP, Smith, DS, Barnwell, SL, Wax, MK. Arterial embolization in the management of posterior epistaxis. Otolaryngol Head Neck Surg 2005;133:748–53Google Scholar
47 Cohen, JE, Moscovici, S, Gomori, JM, Eliashar, R, Weinberger, J, Itshayek, E. Selective endovascular embolization for refractory idiopathic epistaxis is a safe and effective therapeutic option: technique, complications, and outcomes. J Clin Neurosci 2012;19:687–90Google Scholar
48 Duncan, IC, Fourie, PA, le Grange, CE, van der Walt, HA. Endovascular treatment of intractable epistaxis–results of a 4-year local audit. S Afr Med J 2004;94:373–8Google Scholar
49 Elahi, MM, Parnes, LS, Fox, AJ, Pelz, DM, Lee, DH. Therapeutic embolization in the treatment of intractable epistaxis. Arch Otolaryngol Head Neck Surg 1995;121:65–9Google Scholar
50 Elden, L, Montanera, W, Terbrugge, K, Willinsky, R, Lasjaunias, P, Charles, D. Angiographic embolization for the treatment of epistaxis: a review of 108 cases. Otolaryngol Head Neck Surg 1994;111:4450 Google Scholar
51 Fukutsuji, K, Nishiike, S, Aihara, T, Uno, M, Harada, T, Gyoten, M et al. Superselective angiographic embolization for intractable epistaxis. Acta Otolaryngol 2008;128:556–60Google Scholar
52 Gottumukkala, R, Kadkhodayan, Y, Moran, CJ, Cross de, WT 3rd, Derdeyn, CP. Impact of vessel choice on outcomes of polyvinyl alcohol embolization for intractable idiopathic epistaxis. J Vasc Interv Radiol 2013;24:234–9Google Scholar
53 Hicks, JN, Vitek, G. Transarterial embolization to control posterior epistaxis. Laryngoscope 1989;99:1027–9Google Scholar
54 Kordecki, K, Lewszuk, A, Janica, J, Rzewnicki, I, Ustymowicz, A, Konopko-Zubrzycka, M et al. Embolization of carotid artery branch in intractable epistaxis. Pol J Radiol 2008;73:3942 Google Scholar
55 Leppanen, M, Seppanen, S, Laranne, J, Kuoppala, K. Microcatheter embolization of intractable idiopathic epistaxis. Cardiovasc Intervent Radiol 1999;22:499503 Google Scholar
56 Lesley, WS, Rangaswamy, R, Patel, DV. Results of epistaxis embosurgery using detachable platinum fibered coils. J Neurointerv Surg 2010;2:171–5Google Scholar
57 Lopez, RR, Casasco, A, Merland, JJ. Present status of embolization for epistaxis. Int J Neuroradiol 1998;4:5660 Google Scholar
58 Moreau, S, De Rugy, MG, Babin, E, Courtheoux, P, Valdazo, A. Supraselective embolization in intractable epistaxis: review of 45 cases. Laryngoscope 1998;108:887–8Google Scholar
59 Oguni, T, Korogi, Y, Yasunaga, T, Sadanaga, T, Uozumi, H, Kawanaka, K et al. Superselective embolisation for intractable idiopathic epistaxis. Br J Radiol 2000;73:1148–53Google Scholar
60 Roberson, GH, Reardon, EJ. Angiography and embolization of the internal maxillary artery for posterior epistaxis. Arch Otolaryngol 1979;105:333–7Google Scholar
61 Sadri, M, Midwinter, K, Ahmed, A, Parker, A. Assessment of safety and efficacy of arterial embolisation in the management of intractable epistaxis. Eur Arch Otorhinolaryngol 2006;263:560–6Google Scholar
62 Scaramuzzi, N, Walsh, RM, Brennan, P, Walsh, M. Treatment of intractable epistaxis using arterial embolization. Clin Otolaryngol Allied Sci 2001;26:307–9Google Scholar
63 Seidel, DU, Remmert, S, Brassel, F, Schlunz-Hendann, M, Meila, D. Superselective microcoil embolization in severe intractable epistaxis: an analysis of 12 consecutive cases from an otorhinolaryngologic and an interventional neuroradiologic point of view. Eur Arch Otorhinolaryngol 2015;272:3317–26Google Scholar
64 Shah, QA. Bilateral tri-arterial embolization for the treatment of epistaxis. J Vasc Interv Neurol 2008;1:102–5Google Scholar
65 Siniluoto, TM, Leinonen, AS, Karttunen, AI, Karjalainen, HK, Jokinen, KE. Embolization for the treatment of posterior epistaxis: an analysis of 31 cases. Arch Otolaryngol Head Neck Surg 1993;119:837–41Google Scholar
66 Strach, K, Schrock, A, Wilhelm, K, Greschus, S, Tschampa, H, Mohlenbruch, M et al. Endovascular treatment of epistaxis: indications, management, and outcome. Cardiovasc Intervent Radiol 2011;34:1190–8Google Scholar
67 Strutz, J, Schumacher, M. Uncontrollable epistaxis. Angiographic localization and embolization. Arch Otolaryngol Head Neck Surg 1990;116:697–9Google Scholar
68 Tseng, EY, Narducci, CA, Willing, SJ, Sillers, MJ. Angiographic embolization for epistaxis: a review of 114 cases. Laryngoscope 1998;108:615–19Google Scholar
69 Vitek, J. Idiopathic intractable epistaxis: endovascular therapy. Radiology 1991;181:113–16Google Scholar
70 Vokes, DE, McIvor, NP, Wattie, WJ, Chaplin, JM, Morton, RP. Endovascular treatment of epistaxis. ANZ J Surg 2004;74:751–3Google Scholar