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Value of patient-reported symptoms in the follow up of patients potentially cured of laryngeal carcinoma

  • J Brandstorp-Boesen (a1), U Zätterström (a1), J F Evensen (a2) and M Boysen (a1)

Abstract

Objective

To evaluate the significance of patients’ ability to recognise symptoms that signify recurrence.

Methods

A retrospective analysis was conducted in Norway of demographic, clinical and follow-up data for patients with laryngeal carcinoma considered free of disease following treatment. The study included clinical data from 732 patients with glottic tumours and 249 patients with supraglottic tumours who were considered cured of disease. Data on the site, time and type of recurrence (symptomatic or asymptomatic) were retrieved.

Results

Recurrence was observed in 127 patients with glottic tumours and 71 with supraglottic tumours. A total of 103 glottic recurrences and 53 supraglottic recurrences were symptomatic. For patients with glottic carcinoma, recurrence detection through symptoms was associated with a favourable post-salvage survival rate compared with asymptomatic recurrences (p = 0.003).

Conclusion

A patient's ability to self-detect ‘red flag’ symptoms and self-initiate visits represents a previously ignored prognostic factor, and may rationalise follow up and improve survival.

Copyright

Corresponding author

Author for correspondence: Dr Morten Boysen, Telthusbakken 39, 0172 Oslo, Norway E-mail: moboysen@online.no

Footnotes

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Dr M Boysen takes responsibility for the integrity of the content of the paper

Footnotes

References

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1Posttreatment surveillance of squamous cell carcinoma of the head and neck cancer. In: https://www.uptodate.com/contents/posttreatment-surveillance-of-squamous-cell-carcinoma-of-the-head-and-neck [21 May 2018]
2Boysen, M, Løvdal, O, Tausjö, J, Winther, F. The value of follow-up in patients treated for squamous cell carcinoma of the head and neck. Eur J Cancer 1992;28:426–30
3Agrawal, A, Hammond, TH, Young, GS, Avon, AL, Ozer, E, Schuller, DE et al. Factors affecting long-term survival in patients with recurrent head and neck cancer may help define the role of post-treatment surveillance. Laryngoscope 2009;119:2135–40
4Kernohan, JR, Clark, JR, Gao, K, Ebrahimi, A, Milross, CG. Predicting the prognosis of oral squamous cell carcinoma after first recurrence. Arch Otolaryngol Head Neck Surg 2010;136:1235–9
5Joshi, A, Calman, F, O'Connell, M, Jeannon, JP, Pracy, P, Simo, R. Current trends in the follow-up of head and neck cancer patients in the UK. Clin Oncol (R Coll Radiol) 2010;22:114–18
6Zätteström, U, Boysen, M, Evensen, JF. Significance of self-reported symptoms as part of follow-up routines in patients treated for oral squamous cell carcinoma. Anticancer Res 2014;64:6593–9
7Pagh, A, Vedtofte, T, Duch, C, Lynggaard, CD, Rubek, N, Lonka, M et al. The value of routine follow-up after treatment for head and neck cancer: a national survey from DAHANCA. Acta Oncol 2013;52:277–84
8Leon, X, Quer, M, Diez, S, Orùs, C, Lopez-Pousa, A, Burguès, J. Second neoplasms in patients with head and neck cancer. Head Neck 1999;21:204–10
9Harmer, MH, ed.; UICC. TNM Classification of Malignant Tumours, 3rd edn. Geneva: UICC, 1982
10Sobin, LH, Wittekind, CH, eds.; UICC. TNM Classification of Malignant Tumours, 6th edn. New York: Wiley-Liss, 2002
11Vermund, H, Boysen, M, Brandenburg, JH, Evensen, J, Jacobsen, AB, Kaalhus, O et al. Primary irradiation, surgery or combined therapy in squamous cell carcinoma of the larynx: a comparison of treatment results from two centers. Acta Oncol 1990;29:489–97
12Vermund, H, Boysen, M, Evensen, J. Recurrence after different primary treatment for cancer of the supraglottic larynx. Acta Oncol 1998;37:167–73
13Mahler, V, Boysen, M, Bröndbo, K. Radiotherapy or CO2 laser surgery in the treatment of T1a glottic carcinoma. Eur Arch Otorhinolaryngol 2010;267:743–50
14Warren, S, Gates, O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer 1932;16:1358–414
15Roman, BR, Goldenberg, D, Givi, B. AHNS Series – Do you know your guidelines? Guideline recommended follow-up and surveillance of head and neck cancer survivors. Head Neck 2016;38:168–74
16Simo, R, Homer, PC, Mackenzie, K, Paleri, V, Roland, N. Follow-up after treatment for head and neck cancer. J Laryngol Otol 2016;130(suppl 2):S208–11
17Grégoire, V, Lefebvre, JL, Licitra, L, Felip, E; EHNS-ESMO-ESTRO Guidelines Working Group. Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(suppl 5):v184–6
18Morton, R, Hay, KD, Macann, A. On completion of curative treatment of head and neck cancer: why follow-up? Curr Opin Otolaryngol Head Neck Surg 2004;2:142–6
19Manikantan, K, Khode, S, Dwivedi, RC, Palav, R, Nutting, CM, Rhys-Evans, P et al. Making sense of post-treatment surveillance in head and neck cancer: when and what of follow-up. Cancer Treat Rev 2009;35:744–53
20de Visscher, AV, Manni, JJ. Routine long-term follow-up in patients treated with curative intent for squamous cell carcinoma of the larynx, pharynx and oral cavity. Does it make sense? Arch Otolaryngol Head Neck Surg 1994;120:934–9
21Flynn, CJ, Khaouam, N, Gardner, S, Higgins, D, Enepekeds, D, Balogh, J et al. The value of periodic follow-up in the detection of recurrences after radical treatment in locally advanced head and neck cancer. Clin Oncol 2010;22:868–73
22Kumar, R, Putnam, G, Robson, AK. Can head and neck cancer patients be discharged after three years? J Laryngol Otol 2013;127:991–6
23Stimpson, P, Batt, M, Vallance, N. Head and neck recurrence: a prospective analysis of 401 follow-up visits to an Australian cancer centre. Clin Otolaryngol 2014;39:289315
24Digonnet, A, Hamoir, M, Andry, G, Haigentz, M Jr, Takes, RP, Silver, CE et al. Post-therapeutic surveillance strategies in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol 2013;270:1569–80
25Ritoe, SC, Krabbe, PF, Kaanders, JA, van den Hoogen, FJ, Verbek, AL, Marres, HA. Value of routine follow-up in patients cured of laryngeal carcinoma. Cancer 2004;101:1382–9
26Haas, I, Hauser, U, Ganzer, U. The dilemma of follow-up in head and neck cancer patients. Eur Arch Otorhinolaryngol 2001;258:177–83
27Nordgren, M, Abendstein, H, Jannert, M, Boysen, M, Ahlner-Elmqvist, M, Silander, E et al. Health-related quality of life five years after diagnosis of laryngeal carcinoma. Int J Radiat Oncol Biol Phys 2003;56:133–43
28Bradley, PJ, Bradley, PT. Searching for metachronous tumours in patients with head and neck cancer: the ideal protocol! Curr Opin Otolaryngol Head Neck Surg 2010;18:124–33
29Lewis, RA, Neal, RD, Williams, NH, France, B, Hendry, M, Russel, D. Nurse-led vs. conventional physician-led follow-up for patients with cancer: systematic review. J Adv Nurs 2009;64:706–23
30Kimman, ML, Bloebaum, MM, Dirksen, CD, Houben, RM, Lambin, P, Boersma, LJ. Patient satisfaction with nurse-led telephone follow-up after curative treatment for breast cancer. BMC Cancer 2010;10:174–83
31de Leeuw, J. Nurse-led Follow-up Care in Head and Neck Cancer Patients. Nijmegen: Radboud University, 2013
32Trinidade, A, Kothari, P, Andreou, Z, Hewitt, RJ, O'Flynn, P. Follow-up in head and neck cancer: patients’ perspective. Int J Health Care Qual Assur 2012;25:145–9
33Kothari, P, Trinidade, A, Hewitt, RJ, Sing, A, O'Flynn, P. The follow-up of patients with head and neck cancer: an analysis of 1,039 patients. Eur Arch Otorhinolaryngol 2010;268:1191–200
34Lester, SE, Wight, RG. “When will I see you again?” Using local recurrence data to develop a regimen for routine surveillance in post-treatment head and neck cancer patients. Clin Otolaryngol 2009;34:546–51
35Schwartz, DL, Rajencran, J, Yuch, B, Coltrera, MC. FDG-PET prediction of head and neck squamous cell carcinoma cancer outcomes. Arch Otolaryngol Head Neck Surg 2004;130:1361–7
36Goerres, GW, Schmid, DT, Bandhauer, F, Hugenin, PU, von Schulthess, G, Schmid, S et al. Positron emission tomography in the early follow-up of advanced head and neck cancer. Arch Otolaryngol Head Neck Surg 2004;130:105–9
37Zbären, P, de Bree, R, Takes, P, Rinaldo, A, Ferlito, A. Which is the most reliable diagnostic modality for detecting locally residual or recurrent laryngeal squamous cell carcinoma after (chemo)radiotherapy? Eur Arch Otorhinolaryngol 2013;270:2787–91
39Geurts, TW, Balm, AJ, van Velthuisen, ML, van Tinteren, H, Burgers, JA, van Zandwijk, N. Survival after surgical resection of pulmonary metastasis and second primary squamous cell carcinomas in head and neck cancer patients. Head Neck 2009;31:220–6
40Steinkamp, HJ, Wissgott, C, Rademaker, J, Felix, R. Current status of power Doppler and color Doppler sonography in the differential diagnosis of lymph node lesions. Eur Radiol 2002;12:1785–93
41Wolfsenberger, M. Consumption and value of regular after care by patients with squamous cell carcinomas of the larynx, mouth cavity and pharynx [in German]. HNO 1988;36:2833
42Virgo, KS, Paniello, RC, Johnson, FE. Costs of posttreatment surveillance for patients with upper aerodigestive tract cancer. Arch Otolaryngol Head Neck Surg 1998;124:564–72
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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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