Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 5
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Tang, H. Gouldstone, A. and DiMarzio, C.A. 2015. 2015 41st Annual Northeast Biomedical Engineering Conference (NEBEC). p. 1.

    Golabchi, Ali Faust, J. Golabchi, F. N. Brooks, D. H. Gouldstone, A. and DiMarzio, C. A. 2012. Refractive errors and corrections for OCT images in an inflated lung phantom. Biomedical Optics Express, Vol. 3, Issue. 5, p. 1101.

    Golabchi, F. N. Brooks, D. H. Gouldstone, A. and DiMarzio, C. A. 2011. 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. p. 7771.

    Gouldstone, A. Caner, N. Swedish, T. B. Kalkhoran, S. M. and DiMarzio, C. A. 2011. Mechanical and Optical Dynamic Model of Lung. IEEE Transactions on Biomedical Engineering, Vol. 58, Issue. 10, p. 3012.

    Silva, Maricris R. Shen, Hsuan-Tso Marzban, Ali and Gouldstone, Andrew 2010. Instrumented Indentation of Lung Reveals Significant Short Term Alteration in Mechanical Behavior with 100% Oxygen. Journal of Healthcare Engineering, Vol. 1, Issue. 3, p. 415.


Spherical indentation of lungs: Experiments, modeling and sub-surface imaging

  • Maricris R. Silva (a1), Zhijia Yuan (a2), Jae Hun Kim (a3), Zhenguo Wang (a2), Melissa Hoyos (a3), Yingtian Pan (a2) and Andrew Gouldstone (a1)
  • DOI:
  • Published online: 01 January 2011

Knowledge of mechanics in atelectasis (alveolar collapse) and reinflation would be useful during anesthesia and critical care. Here an investigation is presented in which atelectasis is induced in a controlled manner on excised inflated lungs using spherical indentation, and noninvasive imaging of the deformed subsurface region is performed using optical coherence tomography (OCT). Indentation loads are physiologic, and spatial dimensions are far larger than alveolar size to allow continuum discussions. Experimental observations of atelectasis are compared with finite element model calculations of maximum stresses. Finally, atelectasis is compared during inflation of lungs with different gases (e.g., air, oxygen/anesthesia mixture).

Corresponding author
b) Address all correspondence to this author. e-mail:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2.A.P. Sarnaik , K.M. Daphtary , K.L. Meert , M.W. Lieh-Lai , and S.M. Heidemann : Pressure-controlled ventilation in children with severe status asthmaticus. Pediatr. Crit. Care Med. 5, 133 (2004).

3.D. Dreyfuss and G. Saumon : Ventilator-induced lung injury—Lessons from experimental studies. Am. J. Respir. Crit. Care Med. 157, 294 (1998).

4.M. Duggan and B.P. Kavanagh : Pulmonary atelectasis-A pathogenic perioperative entity. Anesthesioloev 102, 838 (2005).

5.L. Magnusson and D.R. Spahn : New concepts of atelectasis during general anaesthesia. Br. J. Anaesth. 91, 61 (2003).

8.M.A. Hajji : Indentation of a membrane on an elastic half space. J. Appl. Mech. Trans. ASME 45, 320 (1978).

12.K. Aoshiba , N. Yokohori , and A. Nagai : Alveolar wall apoptosis causes lung destruction and emphysematous changes. Am. J. Respir. Cell Mol. Biol. 28, 555 (2003).

14.N. Hanna , D. Saltzman , D. Mukai , Z. Chen , S. Sasse , J. Milliken , S. Guo , W. Jung , H. Colt , and M. Brenner : Two-dimensional and з-dimensional optical coherence tomographic imaging of the airway, lung, and pleura. J. Thorac. Cardiovasc. Surg. 129, 615 (2005).

15.D. Huang , E.A. Swanson , C.P. Lin , J.S. Schuman , W.G. Stinson , W. Chang , M.R. Hee , T. Flotte , K. Gregory , C.A. Puliafito , and J.G. Fujimoto : Optical coherence tomography. Science 254, 1178 (1991).

16.A. Popp , M. Wendel , L. Knells , T. Koch , and E. Koch : Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography. J. Biomed. Opt. 11, 014015 (2006).

18.A. Gouldstone , R.E. Brown , J.P. Butler , and S.H. Loring : Stiffness of the pleural surface of the chest wall is similar to that of lung. J. Appl. Physiol. 95, 2345 (2003).

22.Y.Y. Zuo , R.A.W. Veldhuizen , A.W. Neumann , N.O. Petersen , and F. Possmayer : Current perspectives in pulmonary surfactant-Inhibition, enhancement and evaluation. Biochim. Biophys. Acta 1778, 1947 (2008).

26.P. Ruiz and D. Chartrand : The effect of isoflurane 0.6% on respiratory mechanics in anesthetized-paralyzed humans is not increased at concentrations of 0.9% and 1.2%. Can. J. Anaesth. 50, 67 (2003).

27.J. Sato , N. Shinozuka , A. Kochi , H. Uchida , and T. Mizuguchi : Low-dose halothane produces airway dilatation but does not alter parenchymal mechanics in the normal canine lung. Can. J. Anaesth. 42, 438 (1995).

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Materials Research
  • ISSN: 0884-2914
  • EISSN: 2044-5326
  • URL: /core/journals/journal-of-materials-research
Please enter your name
Please enter a valid email address
Who would you like to send this to? *