Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
Hostname: page-component-ffbbcc459-ms7tc Total loading time: 3.035 Render date: 2022-03-15T17:12:19.603Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true }
  • English
Journal of Mental Science Journal of Mental Science

Article contents

Schizophrenia: A New Approach. II. Result of a Year's Research

Published online by Cambridge University Press:  08 February 2018

Abram Hoffer ,
Humphrey Osmond  and
John Smythies
Abram Hoffer
Affiliation:
Psychiatric Research in the Psychiatric Services Branch of the Department of Public Health, Saskatchewan
Humphrey Osmond
Affiliation:
Saskatchewan Hospital, Weyburn, Saskatchewan
John Smythies
Affiliation:
Saskatchewan Hospital, Weyburn, Saskatchwan
Get access Rights & Permissions[Opens in a new window]

Extract

About one year ago, with the encouragement of the Editor-in-Chief, a short paper appeared in this Journal entitled “Schizophrenia; A New Approach” (18). In this paper it was noted that mescaline and adrenaline have a similar biochemical structure. It was suggested that one of the aetiological agents in schizophrenia might be a substance or substances lying between these two; with the psychological properties of mescaline but effective in concentrations nearer those of adrenaline. Dr. Harley Mason elaborated this suggestion from the biochemical standpoint. For convenience these hypothetical substances were called, collectively, M substance. If M substance occurred in the body, it would account for the group of illnesses usually referred to as schizophrenia better than any hypothesis so far advanced. It has been the good fortune of the co-authors of that first paper (J. R. S. and H. O.) to be able to join forces with the third author of this paper (A. H.) to test the hypothsis. It is with the efforts of the last year that this paper is concerned.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 100 , Issue 418 , January 1954 , pp. 29 - 45
Copyright
Copyright © Royal College of Psychiatrists, 1954 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Asouith, E., 1952. Private communication.Google Scholar
2. Bacq, Z. M., J. of Pharm. Exp. Ther., 1949, 95, 1.Google Scholar
3. Beyer, K. H., ibid., 1941, 71, 151.Google Scholar
4. Idem, Physiol. Rev., 1946, 26, 169.CrossRefGoogle Scholar
5. Blaschko, H., Nature, 1940, 145, 26.CrossRefGoogle Scholar
6. Bullough, W. S., The J. of Endocrinology, 1952, 8, 265.CrossRefGoogle Scholar
7. Burn, J. H., Brit. Med. J., 1952, i, 784.CrossRefGoogle Scholar
8. Eade, N., Hutcheon, D. E., 1952. Personal communication—to be published.Google Scholar
9. Fischer, R., Georgi, F., Weber, R., Piaget, R. H., Schweiz. Med. Wchnschr., 1950, 80, 129.Google Scholar
10. Green, D. E., Richter, D., Biochem. J., 1937, 31, 596.CrossRefGoogle Scholar
11. De Jong, H. H., Experimental Catatonia, 1945. Baltimore: The Williams & Wilkins Co.Google Scholar
12. Lettre, H., J. Clin. and Exp. Psychopath., 1951, 12, 241.Google Scholar
13. Lindemann, E., Am. J. Psychiat., 1935, 91, 983.CrossRefGoogle Scholar
14. Manske, R. H. F., Holmes, H. L., The Alkaloids, Vol. II, 1952. New York: Academic Press Inc.Google Scholar
15. Martin, G. J., Biological Antagonism, 1951. Toronto: The Blakeston Co., Inc.Google Scholar
16. Idem , Ichniowski, C. T., Wisansky, W. A., Ansbacher, S., Am. J. Physiol., 1942, 136, 66.Google Scholar
17. Meyerhof, O., Randall, L. O., Archiv. Biochem., 1948, 17, 171.Google Scholar
18. Osmond, H., Smythies, J., J. Ment. Sci., 1952, 98, 309.CrossRefGoogle Scholar
19. Szatmari, A., 1952. Personal communication—to be published.Google Scholar
20. Woodford, V., 1952. Private communication—to be published Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.
228
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Schizophrenia: A New Approach. II. Result of a Year's Research
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Schizophrenia: A New Approach. II. Result of a Year's Research
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Schizophrenia: A New Approach. II. Result of a Year's Research
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *