Dr. Sprengeler, in a paper of 35 pages, gives the results of a laborious statistical inquiry into the causes of this malady. His observations were made at the asylum at Wehnen, near Göttingen, upon 337 paralytics, 295 of whom were men, and 42 women. He found the proportion of male to female paralytics to be about 7 to 1. Most of the cases occurred about the thirty-sixth to the fortieth year of life. The average duration of the disease was two years and eight months; about 74 per cent. of his patients died in the first three years. With women, general paralysis took a slower course, the average duration being about three years and five and a half months. The duration of the disease was the same whether it occurred at an early or late period of life. He gives statistics, the condensed results of many (46) observers, as to the occurrence of syphilis as an ætiological factor in general paralysis.
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