Skip to main content
×
×
Home

Bacterial Change in Mental Disorder: The Bacterial Digestion of Tyrosine

  • F. H. Stewart (a1)
Extract

In a previous paper (Journ. Ment. Sci., April, 1928, p. 269) the writer has pointed out that a culture tube of tyrosine bouillon, if inoculated from the fæces of a healthy person, incubated for forty-eight hours and distilled, will be found to contain not more than cr0.008% of phenol, or at most 0.015%. If, on the other hand, similar cultures are made from mental patients they will contain 0.02 to 0.03% of phenol in one half of the persons examined. In all these cases the phenol is formed by the action of bacteria on the tyrosine in an alkaline medium. The most important phenol-producing bacterium in the insane is B. Morgani, which can be demonstrated in 25% of acute cases, while B. phenologenes, Berthelot, is found in a smaller number. The paper referred to dealt with the toxic effects of B. Morgani and the results of vaccination with this organism. In the present paper another aspect of the matter will be considered, namely, the production of tyramine from tyrosine by intestinal bacteria, and whether poisoning by this substance may be a cause of mental disturbance.

Copyright
References
Hide All
Barger, G., The Simpler Natural Bases. Tyramine and Phenol: Berthelot, 1918, Ann. de l'Institut Pasteur, xxxii, p. 17.
Berthelot, and Bertrand, , 1911, C.R. Soc. Biol.
Dobrowotski, , 1910, Ann. Inst. Past., xxiv, p. 595.
Ewins, and Laidlaw, , 1910, Journ. Physiol., p. 78.
Frohlich, and Pick, , 1913, Arch. of Exp. Path. and Pharm., lxxi, p. 23.
Harvey, W. H., 1911, Journ. Path. and Bact., xvi, p. 95.
Hanke, and Koessler, , 1919, Journ. Biol. Chem., pp. 497 and 521.
Idem. , 1922, ibid., p. 131.
Idem. , 1923, ibid., pp. 879 and 889.
Idem. , 1924, ibid., pp. 835 and 867. Ergot : Robertson and Ashby, 1928, Brit. Med. Journ., i, p. 302.
Histamine, : Bertrand and Berthelot, 1913, Lancet, lxxxiv, p. 523.
Dale, and Laidlaw, , 1910, Journ. Physiol., xli, p. 318.
Eustis, , 1912, A., Amer. Journ. Med. Sci., cxlvi, p. 862, quoted by Martindale, and Westcott, , Extra Pharmacopœia, 1920, p. 399.
Meakins, and Harington, , 1923, Journ. Phar. Exp. Therap., xx, p. 45.
Mellanby, , 1911, Lancet, ii, p. 8.
Mellanby, and Twort, , 1912, Journ. Physiol., xlv, p. 52.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: -
  • EISSN: 2514-9946
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 2 *
Loading metrics...

Abstract views

Total abstract views: 7 *
Loading metrics...

* Views captured on Cambridge Core between 19th February 2018 - 18th June 2018. This data will be updated every 24 hours.

Bacterial Change in Mental Disorder: The Bacterial Digestion of Tyrosine

  • F. H. Stewart (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *