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The Boltz (Acetic-Anhydride) Test in Cerebro-Spinal Fluid

  • C. Thomas (a1)

The acetic anhydride test was introduced in 1923 by Boltz, who regarded a positive result as diagnostic of syphilis of the central nervous system. The technique of the test is simplicity itself, and is as follows: Place 1 c.c. of spinal fluid in a small test-tube. Add 0.3 c.c. of acetic anhydride drop by drop; shake. Add 0.8 c.c. concentrated sulphuric acid drop by drop; shake. After five minutes examine the colour of the fluid against a white background. A lilac or blue-pink coloration is positive.

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1 Boltz, O. H., Amer. Journ. Psychiat., 1923, iii, p. 111; State Hosp. Quart., February, 1923.
2 Greenfield, J. G., and Carmichael, E. A., Journ. of Neur. and Psychopath., 1927, No. 27, vii, p. 220.
3 Herbert, F. K., Brit. Med. Journ., November 23, 1929, p. 953.
4 Grossman, S., ibid., December 7th, 1929, p. 1084.
5 Harris, J. S., ibid., 1926, i, p. 136.
6 Silverston, J. D., Board of Control Annual Report for 1925 (1926).
7 Fleming, G. W. T. H., Journ. Ment. Sci., 1926, lxxii, p. 376.
8 Steele, and Nicole, , Brit. Journ. Ven. Dis., 1926, ii, p. 243.
9 Grossman, S., Journ. Ment. Sci., July, 1925, lxxi, p. 441.
10 Poynder, E. G., and Russell, J., ibid., January, 1926, p. 66.
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The British Journal of Psychiatry
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  • EISSN: 2514-9946
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The Boltz (Acetic-Anhydride) Test in Cerebro-Spinal Fluid

  • C. Thomas (a1)
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