In 1897, and again in 1899, Dr. Macleod drew attention to a new method of employing the bromides as sedatives. His method might be described as that of the massive dose, two drachms of the drug being given in half a tumbler of water every two hours (during the day) till an ounce is given. On the second day a similar amount is given in the same way, and this may suffice to induce a sleep lasting from five to nine days. During this sleep the patient is not so deeply unconscious that he cannot be roused to micturate, or for the bowels to act, or for the administration of food; but left to himself he would starve, and the organic functions work unnoticed. Feeding must be rigorously maintained, and a tumblerful of milk every two hours up to seven tumblerfuls will suffice to maintain nutrition. Following the sleep is a gradual return of consciousness; this takes some fourteen days, the whole treatment lasting some twenty-one to twenty-four days.
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