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The Colloidal Gold Reaction with Cerebrospinal Fluid

  • Thomas Houston (a1) and Edward Armstrong (a1)

The history of the colloidal gold reaction is one of great interest. In 1901 Zsigmondy used the precipitation of colloidal gold by proteins as a means of determining quantitatively their amount in given solutions. He discovered that solutions of protein give protection to colloidal solutions of gold up to a certain point, and he determined the so-called goldzahl for various protein substances, by which is meant the number of milligrammes of protein employed, just sufficient to prevent the precipitation of 10 c.c. of colloidal gold of a percentage of .0053 in the presence of 1 c.c. of 10 per cent. sodium chloride. By this method it can be determined whether a given protein is absolutely pure, or, granted that this is the case, how much of the protein is present in a given solution.

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(1) Lange, C. (1912).—Berl. klin. Wochenschr., xlix, p. 897.
(2) Miller, S. R. and Levy, R. L. (1914). —Johns Hopkins Hospital Bulletin, xxv, p. 133.
(3) Miller, S. R., Brush, N. D., Hammers, J. S., and Felton, L. L. D. (1915).—Johns Hopkins Hospital Bulletin, xxvi, p. 391.
(4) Hammes, E. M. (1917).—American Journal of Medical Science, cliv, p. 625.
(5) Weston, P. G. (1918).—American Journal of Insanity, lxxiv, p. 431.
(6) Felton, L. D. (1917).—New York Medical Journal, cv, p. 1170.
(7) Cruickshank, J. (1920).—British Journal of Experimental Pathology, i, p. 71.
(8) Mellanby, J., and Anwyl Davies, T. (1923).—British Journal of Experimental Pathology, iv, p. 132.
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The Colloidal Gold Reaction with Cerebrospinal Fluid

  • Thomas Houston (a1) and Edward Armstrong (a1)
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