Dr. Anton, of Graz, described a patient who was of a neurotic heredity, had severe attacks of epilepsy, but no symptoms of cerebritis, although there was a certain slowness in spontaneous movements. The intelligence was always good. He died at the age of twenty years in the status epilepticus. The outer vault of the skull was found to be as thin as paper, and even the bones of the base of the cranium were wasted. The occipital curve was flattened. The brain was of strikingly large size, and weighed not less than 2055 grammes. It was thus one of the heaviest on record. The hypertrophy was general, the proportions of the parts being preserved. For example, the cerebellum was 11 per cent., as in the normal brains. The fissures were very deep, but the proportion of the grey and white substance was normal. There was some hydrocephalus internus, though not considerable. The thymus gland was larger than usual; its blood-supply came directly from the innominate artery. The muscular tissue of the heart was degenerated. Anton thinks that this might be the sequel of immoderate dosing with bromides. The supra-renal capsules were invaded by cysts so that the central substance was quite destroyed; the cortical substance remained, though pathologically altered.
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