In this preliminary note, Ceni states shortly the results of further experiments which he has undertaken in the investigation of the properties of the blood-serum in epilepsy. His earlier researches, which have been reported in the Journal, led him to the view that the serum of the epileptic contained two active principles—roughly speaking, a toxin and an antitoxin,—and that the inconstancy of the effects of serum injections was due to the opposite properties of these principles. In the inquiries which he now describes he subjected guinea-pigs to a course of injections with epileptic serum, and then injected the serum of these vaccinated animals into a number of epileptics. As a constant result the patients showed phenomena of reaction, local and general, the latter being of a clearly specific sort, viz., rise of temperature with a characteristic state of mental confusion—an epileptic psychosis, often with increased frequency of motor attacks. On the other hand, normal blood-serum of guinea-pigs injected into epileptic patients gave rise to no such specific reaction; and the serum of guinea-pigs previously treated with non-epileptic serum was almost equally inert. Further, the serum which gave characteristic results with epileptics had practically no effect on non-epileptic patients.
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