Tryparsamide, the sodium salt of N-phenylglycineanmid-p-arsonic acid, was first prepared by Jacobs and Heidelberger in 1915 in the laboratories of the Rockefeller Institute. Following on the excellent reports of its efficacy in the treatment of neuro-syphilis in America, it was distributed to various research centres in this country through the agency of the Medical Research Council prior to its liberation for general use.
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Tryparsamide Therapy in General Paralysis of the Insane
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