Civil society has been associated with challenges and popular struggles for state and democratic reforms. Though these may relate to the articulation of substantive ethnic, regional and communal demands, few studies have addressed the dynamics and ramifications of their engagement in struggles other than democratisation. This study focuses on the ramifications of the entrance of civil society into a regional resource agitation in the Niger Delta region of Nigeria. The study finds that civil society has flowered, taken over and escalated the struggle and constructed itself into a solid formation of regional resistance. Civil groups have reconstructed the agitation into a broad, participatory, highly mobilised and coordinated struggle and redirected it into a struggle for self-determination, equity and civil and environmental rights. The study denotes the roles that civil society can play in the sociopolitical process and reveals the dynamics of their encounters with the state and multinational corporations.