Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Open access
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Marx, Tennille 2015. Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults.


    Martínez-Abad, Beatriz Garrote, José A. Bernardo, David Montalvillo, Enrique Escudero-Hernández, Celia Vázquez, Enrique Rueda, Ricardo and Arranz, Eduardo 2016. Differential immunomodulatory effects of Lactobacillus rhamnosus DR20, Lactobacillus fermentum CECT 5716 and Bifidobacterium animalis subsp. lactis on monocyte-derived dendritic cells. Journal of Functional Foods, Vol. 22, p. 300.


    Sharma, Rohit Kapila, Rajeev Kapasiya, Meena Saliganti, Vamshi Dass, Gulshan and Kapila, Suman 2014. Dietary supplementation of milk fermented with probiotic Lactobacillus fermentum enhances systemic immune response and antioxidant capacity in aging mice. Nutrition Research, Vol. 34, Issue. 11, p. 968.


    ×
  • Journal of Nutritional Science, Volume 2
  • 2013, e44

Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes

  • Sujira Maneerat (a1), Markus J. Lehtinen (a2), Caroline E. Childs (a1), Sofia D. Forssten (a2), Esa Alhoniemi (a3), Milin Tiphaine (a1), Parveen Yaqoob (a1), Arthur C. Ouwehand (a2) and Robert A. Rastall (a1)
  • DOI: http://dx.doi.org/10.1017/jns.2013.31
  • Published online: 02 January 2014
Abstract
Abstract

Elderly adults have alterations in their gut microbiota and immune functions that are associated with higher susceptibility to infections and metabolic disorders. Probiotics and prebiotics, and their synbiotic combinations are food supplements that have been shown to improve both gut and immune function. The objective of this randomised, double-blind, placebo-controlled, cross-over human clinical trial was to study immune function and the gut microbiota in healthy elderly adults. Volunteers (n 37) consumed prebiotic galacto-oligosaccharides (GOS; 8 g/d), probiotic Bifidobacterium lactis Bi-07 (Bi-07; 109 colony-forming units/d), their combination (Bi-07 + GOS) and maltodextrin control (8 g/d) in four 3-week periods separated by 4-week wash-out periods. Immune function was analysed by determining the phagocytic and oxidative burst activity of monocytes and granulocytes, whole-blood response to lipopolysaccharide, plasma chemokine concentrations and salivary IgA levels. Gut microbiota composition and faecal SCFA content were determined using 16S ribosomal RNA fluorescence in situ hybridisation and HPLC, respectively. Primary statistical analyses indicated the presence of carry-over effects and thus measurements from only the first supplementation period were considered valid. Subsequent statistical analysis showed that consumption of Bi-07 improved the phagocytic activity of monocytes (P < 0·001) and granulocytes (P = 0·02). Other parameters were unchanged. We have for the first time shown that the probiotic Bi-07 may provide health benefits to elderly individuals by improving the phagocytic activity of monocytes and granulocytes. The present results also suggest that in the elderly, the effects of some probiotics and prebiotics may last longer than in adults.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes
      Available formats
      ×
Copyright
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license <http://creativecommons.org/licenses/by/3.0/>.
Corresponding author
*Corresponding author: Dr Caroline Childs, fax +44 23 8079 4221, email c.e.childs@soton.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.E Biagi , M Candela , S Fairweather-Tait , (2012) Aging of the human metaorganism: the microbial counterpart. Age (Dordr) 34, 247267.

2.MJ Hopkins , R Sharp & GT Macfarlane (2001) Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48, 198205.

3.E Biagi , L Nylund , M Candela , (2010) Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS ONE 5, e10667.

4.MJ Claesson , S Cusack , O O'Sullivan , (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 108, Suppl. 1, 45864591.

5.S Mueller , K Saunier , C Hanisch , (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72, 10271033.

6.M Rajilic-Stojanovic , HG Heilig , D Molenaar , (2009) Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults. Environ Microbiol 11, 17361751.


8.EJ Woodmansey , ME McMurdo , GT Macfarlane , (2004) Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects. Appl Environ Microbiol 70, 61136122.

9.D Mariat , O Firmesse , F Levenez , (2009) The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol 9, 123.

10.K Fujihashi & H Kiyono (2009) Mucosal immunosenescence: new developments and vaccines to control infectious diseases. Trends Immunol 30, 334343.

11.AC Shaw , S Joshi , H Greenwood , (2010) Aging of the innate immune system. Curr Opin Immunol 22, 507513.

12.AC Shaw , A Panda , SR Joshi , (2011) Dysregulation of human Toll-like receptor function in aging. Ageing Res Rev 10, 346353.

15.RA Rastall , GR Gibson , HS Gill , (2005) Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: an overview of enabling science and potential applications. FEMS Microbiol Ecol 52, 145152.

16.K Tiihonen , AC Ouwehand & N Rautonen (2010) Human intestinal microbiota and healthy ageing. Ageing Res Rev 9, 107116.

17.GR Gibson , KP Scott , RA Rastall , (2011) Dietary prebiotics: current status and new definition. Food Sci Tech Bull Funct Foods 7, 119.

19.W van Dokkum , B Wezendonk , TS Srikumar (1999) Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. Eur J Clin Nutr 53, 17.

21.D Watson , M O'Connell Motherway , MH Schoterman , (2013) Selective carbohydrate utilization by lactobacilli and bifidobacteria. J Appl Microbiol 114, 11321146.

22.DL Worthley , RK Le Leu , VL Whitehall , (2009) A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 90, 578586.

23.S Fujimori , K Gudis , K Mitsui , (2009) A randomized controlled trial on the efficacy of synbiotic versus probiotic or prebiotic treatment to improve the quality of life in patients with ulcerative colitis. Nutrition 25, 520525.

24.M Alander , J Mättö , W Kneifel , (2001) Effect of galacto-oligosaccharide supplementation on human faecal microflora and on survival and persistence of Bifidobacterium lactis Bb-12 in the gastrointestinal tract. Int Dairy J 11, 817825.

31.W Manz , R Amann , W Ludwig , (1996) Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum CytophagaFlavobacterBacteroides in the natural environment. Microbiology 142, 10971106.

34.HJ Harmsen , AC Wildeboer-Veloo , J Grijpstra , (2000) Development of 16S rRNA-based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl Environ Microbiol 66, 45234527.

35.A Sghir , G Gramet , A Suau , (2000) Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization. Appl Environ Microbiol 66, 22632266.

36.A Suau , V Rochet , A Sghir , (2001) Fusobacterium prausnitzii and related species represent a dominant group within the human fecal flora. Syst Appl Microbiol 24, 139145.


38.H Mäkelainen , S Forssten , M Saarinen , (2010) Xylo-oligosaccharides enhance the growth of bifidobacteria and Bifidobacterium lactis in a simulated colon model. Benef Microbes 1, 8191.

39.M Ventura , R Reniero & R Zink (2001) Specific identification and targeted characterization of Bifidobacterium lactis from different environmental isolates by a combined multiplex–PCR approach. Appl Environ Microbiol 67, 27602765.

40.CN Larsen , S Nielsen , P Kaestel , (2006) Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. Eur J Clin Nutr 60, 12841293.

41.LM Davis , I Martinez , J Walter , (2010) A dose dependent impact of prebiotic galactooligosaccharides on the intestinal microbiota of healthy adults. Int J Food Microbiol 144, 285292.

42.LM Davis , I Martinez , J Walter , (2011) Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans. PLoS ONE 6, e25200.

44.HS Gill , KJ Rutherfurd & ML Cross (2001) Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol 21, 264271.

45.K Arunachalam , HS Gill & RK Chandra (2000) Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 54, 263267.

46.EJ Schiffrin , F Rochat , H Link-Amster , (1995) Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci 78, 491497.

47.BL Chiang , YH Sheih , LH Wang , (2000) Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr 54, 849855.

48.B Foligne , S Nutten , C Grangette , (2007) Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World J Gastroenterol 13, 236243.

49.C Franceschi , M Capri , D Monti , (2007) Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 128, 92105.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Nutritional Science
  • ISSN: 2048-6790
  • EISSN: 2048-6790
  • URL: /core/journals/journal-of-nutritional-science
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
UNKNOWN
Supplementary Materials

Maneerat et al. Supplementary Material
Tables

 Unknown (20 KB)
20 KB