Skip to main content
×
×
Home

Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

  • Corrine Hanson (a1), Marina Verdi Schumacher (a1), Elizabeth Lyden (a2), Dejun Su (a2), Jeremy Furtado (a3), Rex Cammack (a4), Bradley Bereitschaft (a4), Matthew Van Ormer (a5), Howard Needelman (a5), Elizabeth McGinn (a5), Katherine Rilett (a5), Caleb Cave (a5), Rebecca Johnson (a5), Kara Weishaar (a5) and Ann Anderson-Berry (a5)...
Abstract

The objective of the present study was to evaluate intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal–infant pairs in the Midwestern USA in relation to measures of health disparities. Concentrations of carotenoids and tocopherols in maternal serum were measured using HPLC and measures of socio-economic status, including food security and food desert residence, were obtained in 180 mothers upon admission to a Midwestern Academic Medical Center labour and delivery unit. The Kruskal–Wallis and independent-samples t tests were used to compare measures between groups; logistic regression models were used to adjust for relevant confounders. P < 0·05 was considered statistically significant. The odds of vitamin A insufficiency/deficiency were 2·17 times higher for non-whites when compared with whites (95 % CI 1·16, 4·05; P = 0·01) after adjustment for relevant confounders. Similarly, the odds of being vitamin E deficient were 3·52 times higher for non-whites (95 % CI 1·51, 8·10; P = 0·003). Those with public health insurance had lower serum lutein concentrations compared with those with private health insurance (P = 0·05), and living in a food desert was associated with lower serum concentrations of β-carotene (P = 0·02), after adjustment for confounders. Subjects with low/marginal food security had higher serum levels of lutein and β-cryptoxanthin compared with those with high food security (P = 0·004 and 0·02 for lutein and β-cryptoxanthin). Diet quality may be a public health concern in economically disadvantaged populations of industrialised societies leading to nutritional disadvantages as well.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery
      Available formats
      ×
Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
*Corresponding author: Corrine Hanson, email ckhanson@unmc.edu
References
Hide All
1.Radhika, MS, Bhaskaram, P, Balakrishna, N, et al. (2002) Effects of vitamin A deficiency during pregnancy on maternal and child health. BJOG 109, 689693.
2.McCauley, ME, van den Broek, N, Dou, L , et al. (2015) Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst Rev, issue 10, CD008666.
3.Zhang, X, Chen, K, Wei, XP, et al. (2009) Perinatal vitamin A status in relation to neurodevelopmental outcome at two years of age. Int J Vitam Nutr Res 79, 238249.
4.Azais-Braesco, V & Pascal, G (2000) Vitamin A in pregnancy: requirements and safety limits. Am J Clin Nutr 71, 5 Suppl., 1325S1333S.
5.Agarwal, R, Virmani, D, Jaipal, M, et al. (2013) Vitamin A status of low and normal birth weight infants at birth and in early infancy. Indian Pediatr 50, 951953.
6.Major, D, Cadenas, M, Fournier, L, et al. (1998) Retinol status of newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 13, 547549.
7.Spears, K, Cheney, C & Zerzan, J (2004) Low plasma retinol concentrations increase the risk of developing bronchopulmonary dysplasia and long-term respiratory disability in very-low-birth-weight infants. Am J Clin Nutr 80, 15891594.
8.Sommer, A, Katz, J & Tarwotjo, I (1984) Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am J Clin Nutr 40, 10901095.
9.Checkley, W, West, KP Jr, Wise, RA, et al. (2010) Maternal vitamin A supplementation and lung function in offspring. N Engl J Med 362, 17841794.
10.Sommer, AVK (2012) A global clinical view on vitamin A and carotenoids. Am J Clin Nutr 96, Suppl., 1204S1206S.
11.Giampietri, M, Lorenzoni, F, Moscuzza, F, et al. (2016) Lutein and neurodevelopment in preterm infants. Front Neurosci 10, 411.
12.Vishwanathan, R, Kuchan, MJ, Sen, S, et al. (2014) Lutein and preterm infants with decreased concentrations of brain carotenoids. J Pediatr Gastroenterol Nutr 59, 659665.
13.Vishwanathan, R, Neuringer, M, Snodderly, DM, et al. (2013) Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates. Nutr Neurosci 16, 2129.
14.Food and Nutrition Board, Institute of Medicine (2000) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academies Press.
15.Bell, EF, Hansen, NI, Brion, LP, et al. (2013) Serum tocopherol levels in very preterm infants after a single dose of vitamin E at birth. Pediatrics 132, e1626e1633.
16.Jiang, Q, Christen, S, Shigenaga, MK, et al. (2001) γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74, 714722.
17.Abdala-Valencia, H, Berdnikovs, S & Cook-Mills, JM (2013) Vitamin E isoforms as modulators of lung inflammation. Nutrients 5, 43474363.
18.McCary, CA, Abdala-Valencia, H, Berdnikovs, S, et al. (2011) Supplemental and highly elevated tocopherol doses differentially regulate allergic inflammation: reversibility of α-tocopherol and γ-tocopherol's effects. J Immunol 186, 36743685.
19.Berdnikovs, S, Abdala-Valencia, H, McCary, C, et al. (2009) Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol 182, 43954405.
20.Cook-Mills, JM, Abdala-Valencia, H & Hartert, T (2013) Two faces of vitamin E in the lung. Am J Respir Crit Care Med 188, 279284.
21.McCary, CA, Yoon, Y, Panagabko, C, et al. (2012) Vitamin E isoforms directly bind PKCα and differentially regulate activation of PKCα. Biochem J 441, 189198.
22.Ghosh-Dastidar, B, Cohen, D, Hunter, G, et al. (2014) Distance to store, food prices, and obesity in urban food deserts. Am J Prev Med 47, 587595.
23.Block, JP & Subramanian, SV (2015) Moving beyond “food deserts”: reorienting United States policies to reduce disparities in diet quality. PLoS Med 12, e1001914.
24.Gubert, MB, Spaniol, AM, Bortolini, GA, et al. (2016) Household food insecurity, nutritional status and morbidity in Brazilian children. Public Health Nutr 19, 22402245.
25.United States Department of Agriculture (2009) Access to affordable and nutritious food: measuring and understanding food deserts and their consequences. Report to Congress. https://www.ers.usda.gov/webdocs/publications/42711/12716_ap036_1_.pdf?v=41055 (accessed March 2018).
26.El-Sohemy, A, Baylin, A, Kabagambe, E, et al. (2002) Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. Am J Clin Nutr 76, 172179.
27.Sivakumar, B, Panth, M, Shatrugna, V, et al. (1997) Vitamin A requirements assessed by plasma response to supplementation during pregnancy. Int J Vitam Nutr Res 67, 232236.
28.Tyson, JE, Wright, LL, Oh, W, et al. (1999) Vitamin A supplementation for extremely-low-birth-weight infants. National Institute of Child Health and Human Development Neonatal Research Network. N Engl J Med 340, 19621968.
29.Biswas, AB, Mitra, NK, Chakraborty, I, et al. (2000) Evaluation of vitamin A status during pregnancy. J Indian Med Assoc 98, 525529.
30.Tanumihardjo, S (2012) Biomarkers of vitamin A status: what do they mean? In World Health Organization Report: Priorities in the Assessment of Vitamin A and Iron Status in Populations, p. 12. Panama City, Panama, 15–17 September 2010. http://apps.who.int/iris/bitstream/10665/75334/1/9789241504225_eng.pdf (accessed March 2018).
31.Sempos, CT, Johnson, NE, Smith, EL, et al. (1985) Effects of intra-individual and inter-individual variation in repeated dietary records. Am J Epidemiol 121, 120130.
32.Basiotis, PP, Welsh, SO, Cronin, FJ, et al. (1987) Number of days of food intake records required to estimate individual and group nutrient intakes with defined confidence. J Nutr 117, 16381641.
33.Longnecker, MP, Lissner, L, Holden, JM, et al. (1993) The reproducibility and validity of a self-administered semiquantitative food frequency questionnaire in subjects from South Dakota and Wyoming. Epidemiology 4, 356365.
34.Salvini, S, Hunter, DJ, Sampson, L, et al. (1989) Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 18, 858867.
35.Eck, LH, Klesges, RC, Hanson, CL, et al. (1991) Measuring short-term dietary intake: development and testing of a 1-week food frequency questionnaire. J Am Diet Assoc 91, 940945.
36.Stryker, WS, Salvini, S, Stampfer, MJ, et al. (1991) Contributions of specific foods to absolute intake and between-person variation of nutrient consumption. J Am Diet Assoc 91, 172178.
37.Suitor, CJ, Gardner, J & Willett, WC (1989) A comparison of food frequency and diet recall methods in studies of nutrient intake of low-income pregnant women. J Am Diet Assoc 89, 17861794.
38.Hamilton, W, Cook, J, Thompson, W, et al. (1997) Household Food Security in the United States in 1995. Summary Report of the Food Security Measurement Project. United States Department of Agriculture Food and Consumer Service Office of Analysis and Evaluation. https://fns-prod.azureedge.net/sites/default/files/SUMRPT.PDF (accessed March 2018).
39.Rai, D, Bird, JK, McBurney, MI, et al. (2015) Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America? Public Health Nutr 18, 16581669.
40.Krebs-Smith, SM, Guenther, PM, Subar, AF, et al. (2010) Americans do not meet federal dietary recommendations. J Nutr 140, 18321838.
41.Fulgoni, VL 3rd, Keast, DR, Bailey, RL, et al. (2011) Foods, fortificants, and supplements: where do Americans get their nutrients? J Nutr 141, 18471854.
42.Grimm, KA, Foltz, JL, Blanck, HM, et al. (2012) Household income disparities in fruit and vegetable consumption by state and territory: results of the 2009 behavioral risk factor surveillance system. J Acad Nutr Diet 112, 20142021.
43.Di Noia, J, Contento, IR & Schinke, SP (2008) Fat avoidance and replacement behaviors predict low-fat intake among urban African American adolescents. Nutr Res 28, 358363.
44.Di Noia, J, Schinke, SP & Contento, IR (2008) Dietary fat intake among urban, African American adolescents. Eat Behav 9, 251256.
45.Casagrande, SS, Wang, Y, Anderson, C, et al. (2007) Have Americans increased their fruit and vegetable intake? The trends between 1988 and 2002. Am J Prev Med 32, 257263.
46.Pilch, SM (1987) Analysis of vitamin A data from the Health and Nutrition Examination Surveys. J Nutr 117, 636640.
47.Ballew, C, Bowman, BA, Sowell, AL, et al. (2001) Serum retinol distributions in residents of the United States: Third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 73, 586593.
48.Hanson, C, Lyden, E, Abresch, C, et al. (2016) Serum retinol concentrations, race, and socioeconomic status in of women of childbearing age in the United States. Nutrients 8, 508.
49.Butte, NF & Calloway, DH (1982) Proteins, vitamin A, carotene, folacin, ferritin and zinc in Navajo maternal and cord blood. Biol Neonate 41, 273278.
50.Godel, JC, Basu, TK, Pabst, HF, et al. (1996) Perinatal vitamin A (retinol) status of northern Canadian mothers and their infants. Biol Neonate 69, 133139.
51.Wagner, KH, Kamal-Eldin, A & Elmadfa, I (2004) γ-Tocopherol – an underestimated vitamin? Ann Nutr Metab 48, 169188.
52.Shamim, AA, Schulze, K, Merrill, RD, et al. (2015) First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh. Am J Clin Nutr 101, 294301.
53.Girard, AW, Self, J, McAuliffe, C, et al. (2012) The effects of household food production strategies on the health and nutrition outcomes of women and young children: a systematic review. Paediatr Perinat Epidemiol 26, Suppl. 1, 205222.
54.Kirkpatrick, SI, Dodd, KW, Parsons, R, et al. (2015) Household food insecurity is a stronger marker of adequacy of nutrient intakes among Canadian compared to American youth and adults. J Nutr 145, 15961603.
55.McGuire, S (2015) FAO, IFAD, and WFP. The state of food insecurity in the world 2015: meeting the 2015 international hunger targets: taking stock of uneven progress. Rome: FAO, 2015. Adv Nutr 6, 623624.
56.Satia, JA (2009) Diet-related disparities: understanding the problem and accelerating solutions. J Am Diet Assoc 109, 610615.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of Nutritional Science
  • ISSN: 2048-6790
  • EISSN: 2048-6790
  • URL: /core/journals/journal-of-nutritional-science
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed