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    Leonard, Alecia Chalmers, Kerry Collins, Clare and Patterson, Amanda 2014. A Study of the Effects of Latent Iron Deficiency on Measures of Cognition: A Pilot Randomised Controlled Trial of Iron Supplementation in Young Women. Nutrients, Vol. 6, Issue. 6, p. 2419.


    Jackson, Jacklyn Williams, Rebecca McEvoy, Mark MacDonald-Wicks, Lesley and Patterson, Amanda 2016. Is Higher Consumption of Animal Flesh Foods Associated with Better Iron Status among Adults in Developed Countries? A Systematic Review. Nutrients, Vol. 8, Issue. 2, p. 89.


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  • Journal of Nutritional Science, Volume 2
  • 2013, e14

Iron deficiency, cognition, mental health and fatigue in women of childbearing age: a systematic review

  • Alecia J. Greig (a1), Amanda J. Patterson (a1), Clare E. Collins (a1) and Kerry A. Chalmers (a2)
  • DOI: http://dx.doi.org/10.1017/jns.2013.7
  • Published online: 29 April 2013
Abstract
Abstract

It is known that Fe deficiency has a negative impact on cognitive function in children by altering brain energy metabolism and neurotransmitter function. It is unclear whether Fe deficiency has detrimental effects on cognition, mental health and fatigue in women of childbearing age. Our aim was to systematically review the literature to determine whether Fe deficiency in women of childbearing age affects cognition, mental health and fatigue, and whether a change in Fe status results in improvements in cognition, mental health and fatigue. Studies using Fe supplement interventions were reviewed to examine the effect of Fe deficiency in women of childbearing age (13–45 years) on their cognition, mental health and fatigue. English-language articles ranging from the earliest record to the year 2011 were sourced. The quality of retrieved articles was assessed and the Fe pathology, cognitive, mental health and fatigue data were extracted. Means and standard deviations from cognitive test data were included in meta-analyses of combined effects. Of the 1348 studies identified, ten were included in the review. Three studies showed poorer cognition and mental health scores and increased fatigue with Fe deficiency at baseline. Seven studies reported an improvement in cognitive test scores after Fe treatment. Results of three of these studies were included in meta-analyses of the effect of Fe supplement intervention on cognition. The results of the meta-analyses showed a significant improvement in Arithmetic scores after treatment (P < 0·01), but no effect on Digit Symbol, Digit Span or Block Design. While an improvement in cognition after Fe treatment was seen in seven out of ten studies, the evidence base is limited by poor study quality and heterogeneity across studies. Additional high-quality studies using consistent measures are warranted.

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Copyright
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence <http://creativecommons.org/licenses/by-nc-sa/2.5/>. The written permission of Cambridge University Press must be obtained for commercial re-use.
Corresponding author
*Corresponding author: A. J. Greig, fax + 61 2 49217053, email Alecia.Greig@uon.edu.au
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3.C Lee , AJ Dobson , WJ Brown , (2005) Cohort profile: the Australian longitudinal study on women's health. Int J Epidemiol 34, 987991.

4.S Samman (2007) Iron. Nutr Diet 64, S126S130.

6.JD Cook (2005) Diagnosis and management of iron-deficiency anaemia. Best Pract Res Clin Haematol 18, 319332.

8.M Falkingham , A Abdelhamid , P Curtis , (2010) The effects of oral iron supplementation on cognition in older children and adults: a systematic review and meta-analysis. Nutr J 9, 4.

9.NS Scrimshaw (1991) Iron deficiency. Sci Am 265, 4652.

10.NS Scrimshaw (1984) Functional consequences of iron-deficiency in human-populations. J Nutr Sci Vitaminol (Tokyo) 30, 4763.

15.K Dwan , DG Altman , JA Arnaiz , (2008) Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS ONE 3, e3081.

16.JA Sterne , AJ Sutton , JP Ioannidis , (2011) Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343, d4002.

21.AB Bruner , A Joffe , AK Duggan , (1996) Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet 348, 992996.

23.PC Elwood & D Hughes (1970) Clinical trial of iron therapy on psychomotor function in anaemic women. Br Med J 3, 254255.

24.JA Groner , NA Holtzman , E Charney , (1986) A randomized trial of oral iron on tests of short-term memory and attention span in young pregnant-women. J Adolesc Health 7, 4448.

26.E Khedr , SA Hamed , E Elbeih , (2008) Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment. Eur Arch Psychiatry Clin Neurosci 258, 489496.

27.J Månsson , G Johansson , M Wiklund , (2005) Symptom panorama in upper secondary school students and symptoms related to iron deficiency. Screening with laboratory tests, questionnaire and interventional treatment with iron. Scand J Prim Health Care 23, 2833.

28.MJ Kretsch , AK Fong , MW Green , (1998) Cognitive function, iron status, and hemoglobin concentration in obese dieting women. Eur J Clin Nutr 52, 512518.

29.A Baddeley (1992) Working memory. Science 255, 556559.

30.AJ Patterson , WJ Brown & DC Roberts (2001) Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age. J Am Coll Nutr 20, 337342.

32.RD Baynes (1996) Assessment of iron status. Clin Biochem 29, 209215.

34.RG Laessle , P Platte , U Schweiger , (1996) Biological and psychological correlates of intermittent dieting behavior in young women. A model for bulimia nervosa. Physiol Behav 60, 15.

35.WD Lassek & SJC Gaulin (2008) Waist-hip ratio and cognitive ability: is gluteofemoral fat a privileged store of neurodevelopmental resources? Evol Hum Behav 29, 2634.

36.PM Maki , JB Rich & RS Rosenbaum (2002) Implicit memory varies across the menstrual cycle: estrogen effects in young women. Neuropsychologia 40, 518529.

37.P Vaucher , PL Druais , S Waldvogel , (2012) Effect of iron supplementation on fatigue in nonanemic menstruating women with low ferritin: a randomized controlled trial. Can Med Assoc J 184, 12471254.

38.PA Krayenbuehl , E Battegay , C Breymann , (2011) Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration. Blood 118, 32223227.

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  • ISSN: 2048-6790
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