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Rethinking the Cognitive Mechanisms Underlying Pantomime of Tool Use: Evidence from Alzheimer’s Disease and Semantic Dementia

Published online by Cambridge University Press:  16 February 2017

Mathieu Lesourd ,
Josselin Baumard ,
Christophe Jarry ,
Frédérique Etcharry-Bouyx ,
Serge Belliard ,
Olivier Moreaud ,
Bernard Croisile ,
Valérie Chauviré ,
Marine Granjon  and
Didier Le Gall
...Show all authors
Mathieu Lesourd*
Affiliation:
Laboratoire d’Etude des Mécanismes Cognitifs (EA 3082), Université de Lyon, France Service de Neuropsychologie, Hôpital Neurologique Pierre Wertheimer, Bron, France
Josselin Baumard
Affiliation:
Laboratoire de Psychologie des Pays de la Loire (EA4638), Université d’Angers, France Unité de Neuropsychologie, Département de Neurologie, Centre Hospitalier Universitaire d’Angers, France
Christophe Jarry
Affiliation:
Laboratoire de Psychologie des Pays de la Loire (EA4638), Université d’Angers, France Unité de Neuropsychologie, Département de Neurologie, Centre Hospitalier Universitaire d’Angers, France
Frédérique Etcharry-Bouyx
Affiliation:
Laboratoire de Psychologie des Pays de la Loire (EA4638), Université d’Angers, France Unité de Neuropsychologie, Département de Neurologie, Centre Hospitalier Universitaire d’Angers, France
Serge Belliard
Affiliation:
Service de Neurologie, Centre Hospitalier Universitaire, Rennes, France Laboratoire de Neuropsychologie, Unité INSERM U 1077, Caen, France
Olivier Moreaud
Affiliation:
CMRR Grenoble Arc Alpin, Pôle de Psychiatrie et Neurologie, Centre Hospitalier Universitaire de Grenoble, France Laboratoire de Psychologie et Neurocognition CNRS UMR 5105, Grenoble, France
Bernard Croisile
Affiliation:
Service de Neuropsychologie, Hôpital Neurologique Pierre Wertheimer, Bron, France
Valérie Chauviré
Affiliation:
Département de Neurologie, Centre Hospitalier Universitaire d’Angers, France
Marine Granjon
Affiliation:
Laboratoire d’Etude des Mécanismes Cognitifs (EA 3082), Université de Lyon, France
Didier Le Gall
Affiliation:
Laboratoire de Psychologie des Pays de la Loire (EA4638), Université d’Angers, France Unité de Neuropsychologie, Département de Neurologie, Centre Hospitalier Universitaire d’Angers, France
François Osiurak
Affiliation:
Laboratoire d’Etude des Mécanismes Cognitifs (EA 3082), Université de Lyon, France InstitutUniversitaire de France, Paris, France
*
Correspondence and reprint requests to: Mathieu Lesourd, Laboratoired’Etude des MécanismesCognitifs (EA 3082), Institut de Psychologie, 5, avenue Pierre Mendès-France, 69676 BronCedex, France. E-mail: mathieu.lesourd@chu-lyon.fr
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Abstract

Objectives: Pantomiming the use of familiar tools is a central test in the assessment of apraxia. However, surprisingly, the nature of the underlying cognitive mechanisms remains an unresolved issue. The aim of this study is to shed a new light on this issue by exploring the role of functional, mechanical, and manipulation knowledge in patients with Alzheimer’s disease and semantic dementia and apraxia of tool use. Methods: We performed multiple regression analyses with the global performance and the nature of errors (i.e., production and conception) made during a pantomime of tool use task in patients and control participants as dependent variables and tasks investigating functional, mechanical, and manipulation knowledge as predictors. Results: We found that mechanical problem solving, assessing mechanical knowledge, was a good predictor of the global performance of pantomime of tool use. We also found that occurrence of conception errors was robustly predicted by the task assessing functional knowledge whereas that of production errors was not explained by only one predictor. Conclusions: Our results suggest that both functional and mechanical knowledge are important to pantomime the use of tools. To our knowledge, this is the first demonstration that mechanical knowledge plays a role in pantomime of tool use. Although impairment in pantomime of tool use tasks (i.e., apraxia) is widely explained by the disruption of manipulation knowledge, we propose that pantomime of tool use is a complex problem-solving task. (JINS, 2017, 23, 128–138)

Keywords

ApraxiaAlzheimer’s diseaseSemantic dementiaManipulation knowledgeMechanical knowledgeFunctional knowledgePantomime of tool use
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 23 , Special Issue 2: Special Issue: Motor Cognition , February 2017 , pp. 128 - 138
Copyright
Copyright © The International Neuropsychological Society 2017 

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