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Assessment and quantification of head motion in neuropsychiatric functional imaging research as applied to schizophrenia

Published online by Cambridge University Press:  14 August 2007

ANDREW R. MAYER ,
ALEXANDRE R. FRANCO ,
JOSEF LING  and
JOSE M. CAÑIVE
ANDREW R. MAYER
Affiliation:
The MIND Institute, Albuquerque, New Mexico Neurology Department, University of New Mexico School of Medicine, Albuquerque, New Mexico
ALEXANDRE R. FRANCO
Affiliation:
The MIND Institute, Albuquerque, New Mexico Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, New Mexico
JOSEF LING
Affiliation:
The MIND Institute, Albuquerque, New Mexico
JOSE M. CAÑIVE
Affiliation:
Center for Functional Brain Imaging, New Mexico VA Health Care System, and Departments of Psychiatry and Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico
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Abstract

Differing degrees of head motion have long been recognized as a potential confound in functional neuroimaging studies comparing neuropsychiatric populations to healthy normal volunteers, and studies often cite excessive head motion as a possible reason for the different patterns of functional activation frequently observed between groups. We empirically tested the degree of head motion in 16 patients with chronic schizophrenia and 16, age- and education-matched controls during the acquisition of functional magnetic resonance imaging data. We examined the degree of motion across three different indices (total motion, relative motion, task-correlated motion) during a complex attentional task and the effect of entering the motion parameters as additional regressors in a general linear model analysis. Results indicate that individuals with schizophrenia did not exhibit more task-correlated or total motion compared with controls. Moreover, the residual error term from the general linear model analysis was similar for both groups of subjects. In conclusion, current results suggest that stable patients with schizophrenia are capable of controlling head motion compared with matched normal controls. However, a direct comparison of the motion parameters is an essential step for any quality assurance protocol to determine whether additional corrective techniques need to be implemented. (JINS, 2007, 13, 839–845.)

Keywords

fMRIMotionArtifactNeuropsychiatricSchizophreniaQuality assurance
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 5 , September 2007 , pp. 839 - 845
Copyright
2007 The International Neuropsychological Society

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