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Cognitive Dysfunction and White Matter Abnormalities in Systemic Lupus Erythematosus

  • Elizabeth Kozora (a1) (a2) (a3) and Christopher M. Filley (a2) (a3) (a4)
Abstract

Brain abnormalities have been documented by neuropsychological assessment as well as a variety of neuroimaging techniques in patients with systemic lupus erythematosus (SLE). Conventional neuroimaging in patients with neuropsychiatric disease (NPSLE) typically discloses periventricular white matter (WM) hyperintensities, infarcts, hemorrhages, and cerebral atrophy. In SLE patients with none of these findings, sophisticated neuroimaging techniques have recently supported associations between microstructural WM abnormalities and abnormal attention, executive function, and processing speed. This mild cognitive dysfunction in SLE (MCD-SLE), which may result from early myelinopathy, precedes the more severe cognitive dysfunction of NPSLE, related to more obvious WM and neuronal damage. (JINS, 2011, 17, 385–392)

Copyright
COPYRIGHT: © The International Neuropsychological Society 2011
Corresponding author
Correspondence and reprint requests to: Elizabeth Kozora, Ph.D., National Jewish Health, 1400 Jackson Street, Denver, CO 80206. E-mail: kozorae@njhealth.org
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