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Decreased Cognitive Function in Extended Family Members from the Single Late-Onset-Alzheimer's-Disease Pedigree

Published online by Cambridge University Press:  07 June 2013

Yan Zeng ,
Wei Chang ,
Chang Shu ,
Lina Ma ,
Yuanyuan Huang ,
Ruoshi Wang ,
Junpeng Zhang ,
Changcai Zhu  and
Shawn M. McClintock
Yan Zeng*
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Wei Chang
Affiliation:
Department of Preventive Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Chang Shu
Affiliation:
Department of Preventive Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Lina Ma
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Yuanyuan Huang
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Ruoshi Wang
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Junpeng Zhang
Affiliation:
School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Changcai Zhu
Affiliation:
Department of Preventive Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, China
Shawn M. McClintock
Affiliation:
Neurocognitive Research Laboratory, Division of Brain Stimulation and Neurophysiology, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas
*
Correspondence and reprint requests to: Yan Zeng, Department of Pathophysiology, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China. E-mail: yanzeng11@yahoo.com
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Abstract

A family history of dementia is associated with an increased risk of developing Alzheimer's disease (AD) late in life (LOAD). This study marked the first attempt to assess the familial contribution to differences in cognitive performance in a large family-based group in the Chinese community. We enrolled 168 participants without dementia from a single pedigree with 9 probable AD patients diagnosed after age 65. These participants were evaluated with a comprehensive neuropsychological battery, the Chinese version of the Mini Mental State Examination, and the Alzheimer Disease Assessment Scale–Cognitive Subscale. Analyses found that extended family members of the LOAD pedigree showed similar performance on measures of global cognitive function and semantic memory compared to controls, but lower scores on episodic memory, attention, and executive function measures. These results indicate that the genetic influences on certain sub-cognitive domains are more detectable despite normal global cognitive function, and that family members with the LOAD pedigree are at risk for developing LOAD by virtue of their family history with an additive risk due to increased age. The findings in this study support the importance of documenting if there is a positive family history of AD in clinical evaluations. (JINS, 2013, 19, 1–11)

Keywords

Alzheimer's diseaseDementiaGeneticsMemoryGeriatricPedigree
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 7 , August 2013 , pp. 809 - 819
Copyright
Copyright © The International Neuropsychological Society 2013 

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