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Detection of dementia of the Alzheimer type in a population-based sample: Neuropsychological test performance

Published online by Cambridge University Press:  26 February 2009

Deborah A. Cahn ,
David P. Salmon ,
Nelson Butters ,
Wigbert C. Wiederholt ,
Jody Corey-Bloom ,
Sharon L. Edelstein  and
Elizabeth Barrett-Connor
Deborah A. Cahn
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 Department of Psychology, San Diego State University, San Diego, CA 92182
David P. Salmon
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0948
Nelson Butters
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093
Wigbert C. Wiederholt
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0948
Jody Corey-Bloom
Affiliation:
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093-0948
Sharon L. Edelstein
Affiliation:
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093
Elizabeth Barrett-Connor
Affiliation:
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093
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Abstract

The ability to detect dementia of the Alzheimer type (DAT) in a community-dwelling sample of elderly individuals on the basis of neuropsychological test performance was examined. Three hundred sixty community-dwelling individuals were identified by neurological examination as having probable or possible Alzheimer’s disease, being at risk for Alzheimer’s disease, or having no cognitive impairment. A logistic model comprised of tests of verbal and nonverbal memory, mental flexibility, and confrontation naming correctly classified 82% of DAT subjects and 98% of normal elderly subjects. The logistic model classified 77% of subjects who were diagnosed as at risk for Alzheimer's disease as being cognitively normal. A cross-validation with a clinically based sample of subjects correctly classified 89% of DAT patients and 100% of normal control subjects. The results suggest that psychometric discrimination of dementia may be less accurate in community-dwelling populations than in clinically based samples. (JINS, 1995, I, 252–260.)

Keywords

Neuropsychological testingAlzheimer's diseaseDementia
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 3 , May 1995 , pp. 252 - 260
Copyright
Copyright © The International Neuropsychological Society 1995

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