Skip to main content
×
Home
    • Aa
    • Aa

Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder

  • JESSICA H. KALMAR (a1) (a2), FEI WANG (a1) (a2), LINDA SPENCER (a1) (a2), ERIN EDMISTON (a1) (a2), CHERYL M. LACADIE (a3), ANDRÉS MARTIN (a1) (a4), R. TODD CONSTABLE (a3) (a5) (a6), JAMES S. DUNCAN (a3) (a5) (a7), LAWRENCE H. STAIB (a3) (a5) (a7), XENOPHON PAPADEMETRIS (a3) (a5) and HILARY P. BLUMBERG (a1) (a2) (a3) (a4)...
Abstract
Abstract

Previous cross-sectional study of ventral prefrontal cortex (VPFC) implicated progressive volume abnormalities during adolescence in bipolar disorder (BD). In the present study, a within-subject, longitudinal design was implemented to examine brain volume changes during adolescence/young adulthood. We hypothesized that VPFC volume decreases over time would be greater in adolescents/young adults with BD than in healthy comparison adolescents/young adults. Eighteen adolescents/young adults (10 with BD I and 8 healthy comparison participants) underwent two high-resolution magnetic resonance imaging scans over approximately 2 years. Regional volume changes over time were measured. Adolescents/young adults with BD displayed significantly greater volume loss over time, compared to healthy comparison participants, in a region encompassing VPFC and rostral PFC and extending to rostral anterior cingulate cortex (p < .05). Additional areas where volume change differed between groups were observed. While data should be interpreted cautiously due to modest sample size, this study provides preliminary evidence to support the presence of accelerated loss in VPFC and rostral PFC volume in adolescents/young adults with BD. (JINS, 2009, 15, 476–481.)

Copyright
Corresponding author
*Correspondence and reprint requests to: Jessica H. Kalmar, Mood Disorders Research Program, Department of Psychiatry, Yale School of Medicine, 300 George Street, Suite 901, New Haven, Connecticut 06511. E-mail: jessica.kalmar@yale.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

C.M. Adler , M.P. DelBello , K. Jarvis , A. Levine , J. Adams , & S.M Strakowski . (2007). Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biological Psychiatry, 61(6), 776781.

F. Bermpohl , A. Pascual-Leone , A. Amedi , L.B. Merabet , F. Fregni , N. Gaab , D. Alsop , G. Schlaug , & G Northoff . (2006). Attentional modulation of emotional stimulus processing: An fMRI study using emotional expectancy. Human Brain Mapping, 27(8), 662677.

H.P. Blumberg , D.S. Charney , & J.H Krystal . (2002). Frontotemporal neural systems in bipolar disorder. Seminars in Clinical Neuropsychiatry, 7(4), 243254.

H.P. Blumberg , C. Fredericks , F. Wang , J.H. Kalmar , L. Spencer , X. Papademetris , B. Pittman , A. Martin , B.S. Peterson , R.K. Fulbright , & J.H Krystal . (2005). Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders, 7(6), 570576.

H.P. Blumberg , J. Kaufman , A. Martin , D.S. Charney , J.H. Krystal , & B.S Peterson . (2004). Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Annals of the New York Academy of Sciences, 1021, 376383.

H.P. Blumberg , J.H. Krystal , R. Bansal , A. Martin , J. Dziura , K. Durkin , L. Martin , E. Gerard , D.S. Charney , & B.S Peterson . (2006). Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: A cross-sectional study. Biological Psychiatry, 59(7), 611618.

H.P. Blumberg , H.C. Leung , P. Skudlarski , C.M. Lacadie , C.A. Fredericks , B.C. Harris , D.S. Charney , J.C. Gore , J.H. Krystal , & B.S Peterson . (2003a). A functional magnetic resonance imaging study of bipolar disorder: State- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry, 60(6), 601609.

H.P. Blumberg , A. Martin , J. Kaufman , H.C. Leung , P. Skudlarski , C. Lacadie , R.K. Fulbright , J.C. Gore , D.S. Charney , J.H. Krystal , & B.S Peterson . (2003b). Frontostriatal abnormalities in adolescents with bipolar disorder: Preliminary observations from functional MRI. The American Journal of Psychiatry, 160(7), 13451347.

K. Chang , N. Barnea-Goraly , A. Karchemskiy , D.I. Simeonova , P. Barnes , T. Ketter , & A.L Reiss . (2005). Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder. Biological Psychiatry, 58(3), 197203.

D.P. Dickstein , M.P. Milham , A.C. Nugent , W.C. Drevets , D.S. Charney , D.S. Pine , & E Leibenluft . (2005). Frontotemporal alterations in pediatric bipolar disorder: Results of a voxel-based morphometry study. Archives of General Psychiatry, 62(7), 734741.

W.C. Drevets , J.L. Price , J.R. Simpson Jr., R.D. Todd , T. Reich , M. Vannier , & M.E Raichle . (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386(6627), 824827.

T.F. Farrow , T.J. Whitford , L.M. Williams , L. Gomes , & A.W Harris . (2005). Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biological Psychiatry, 58(9), 713723.

J.A. Frazier , J.L. Breeze , N. Makris , A.S. Giuliano , M.R. Herbert , L. Seidman , J. Biederman , S.M. Hodge , M.E. Dieterich , E.D. Gerstein , D.N. Kennedy , S.L. Rauch , B.M. Cohen , & V.S Caviness . (2005). Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disorders, 7(6), 555569.

J.N. Giedd , J. Blumenthal , N.O. Jeffries , F.X. Castellanos , H. Liu , A. Zijdenbos , T. Paus , A.C. Evans , & J.L Rapoport . (1999). Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neuroscience, 2(10), 861863.

N. Gogtay , J.N. Giedd , L. Lusk , K.M. Hayashi , D. Greenstein , A.C. Vaituzis , T.F. Nugent 3rd, D.H. Herman , L.S. Clasen , A.W. Toga , J.L. Rapoport , & P.M Thompson . (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America, 101(21), 81748179.

N. Gogtay , A. Ordonez , D.H. Herman , K.M. Hayashi , D. Greenstein , C. Vaituzis , M. Lenane , L. Clasen , W. Sharp , J.N. Giedd , D. Jung , T.F. Nugent 3rd, A.W. Toga , E. Leibenluft , P.M. Thompson , & J.L Rapoport . (2007). Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 48(9), 852862.

J. Kaufman , B. Birmaher , D. Brent , U. Rao , C. Flynn , P. Moreci , D. Williamson , & N Ryan . (1997). Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36(7), 980988.

S. Kaur , R.B. Sassi , D. Axelson , M. Nicoletti , P. Brambilla , E.S. Monkul , J.P. Hatch , M.S. Keshavan , N. Ryan , B. Birmaher , & J.C Soares . (2005). Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. The American Journal of Psychiatry, 162(9), 16371643.

D.M. Kronhaus , N.S. Lawrence , A.M. Williams , S. Frangou , M.J. Brammer , S.C. Williams , C.M. Andrew , & M.L Phillips . (2006). Stroop performance in bipolar disorder: Further evidence for abnormalities in the ventral prefrontal cortex. Bipolar Disorders, 8(1), 2839.

E. Leibenluft , B.A. Rich , D.T. Vinton , E.E. Nelson , S.J. Fromm , L.H. Berghorst , P. Joshi , A. Robb , R.J. Schachar , D.P. Dickstein , E.B. McClure , & D.S Pine . (2007). Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder. The American Journal of Psychiatry, 164(1), 5260.

M.P. Lopez-Larson , M.P. DelBello , M.E. Zimmerman , M.L. Schwiers , & S.M Strakowski . (2002). Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biological Psychiatry, 52(2), 93100.

I.K. Lyoo , M.J. Kim , A.L. Stoll , C.M. Demopulos , A.M. Parow , S.R. Dager , S.D. Friedman , D.L. Dunner , & P.F Renshaw . (2004). Frontal lobe gray matter density decreases in bipolar I disorder. Biological Psychiatry, 55(6), 648651.

G.S. Malhi , J. Lagopoulos , P.S. Sachdev , B. Ivanovski , & R Shnier . (2005). An emotional Stroop functional MRI study of euthymic bipolar disorder. Bipolar Disorders, 7(Suppl 5), 5869.

A.C. Nugent , M.P. Milham , E.E. Bain , L. Mah , D.M. Cannon , S. Marrett , C.A. Zarate , D.S. Pine , J.L. Price , & W.C Drevets . (2006). Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage, 30(2), 485497.

M.N. Pavuluri , M.M. O’Connor , E. Harral , & J.A Sweeney . (2007). Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biological Psychiatry, 62(2), 158167.

B.A. Rich , D.T. Vinton , R. Roberson-Nay , R.E. Hommer , L.H. Berghorst , E.B. McClure , S.J. Fromm , D.S. Pine , & E Leibenluft . (2006). Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proceedings of the National Academy of Sciences of the United States of America, 103(23), 89008905.

J.S. Rubinsztein , P.C. Fletcher , R.D. Rogers , L.W. Ho , F.I. Aigbirhio , E.S. Paykel , T.W. Robbins , & B.J Sahakian . (2001). Decision-making in mania: A PET study. Brain, 124(Pt 12), 25502563.

D. Rueckert , L.I. Sonoda , C. Hayes , D.L.G. Hill , M.O. Leach , & D.J Hawkes . (1999). Non-rigid registration using free-form deformations: Application to breast MR images. IEEE Transactions on Medical Imaging, 18(8), 712721

M. Sanches , R.B. Sassi , D. Axelson , M. Nicoletti , P. Brambilla , J.P. Hatch , M.S. Keshavan , N.D. Ryan , B. Birmaher , & J.C Soares . (2005). Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study. Psychiatry Research, 138(1), 4349.

E.R. Sowell , P.M. Thompson , C.J. Holmes , T.L. Jernigan , & A.W Toga . (1999). In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience, 2(10), 859861.

P.M. Thompson , C. Vidal , J.N. Giedd , P. Gochman , J. Blumenthal , R. Nicolson , A.W. Toga , & J.L Rapoport . (2001). Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 98(20), 1165011655.

D.R Weinberger . (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44(7), 660669.

M. Wilke , R.A. Kowatch , M.P. DelBello , N.P. Mills , & S.K Holland . (2004). Voxel-based morphometry in adolescents with bipolar disorder: First results. Psychiatry Research, 131(1), 5769.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Journal of the International Neuropsychological Society
  • ISSN: 1355-6177
  • EISSN: 1469-7661
  • URL: /core/journals/journal-of-the-international-neuropsychological-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: