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Early prediction of long-term cognitive impairment after cardiac arrest

Published online by Cambridge University Press:  01 May 2009

JÖRN PROHL ,
SEBASTIAN BODENBURG  and
STEPHAN JEFF RUSTENBACH
JÖRN PROHL*
Affiliation:
Department of Cognitive Rehabilitation, Neurological Rehabilitation Center Godeshöhe, Academic Teaching Hospital, University of Bonn, Bonn, Germany
SEBASTIAN BODENBURG
Affiliation:
Neuropsychological Office, Hamburg, Germany* Department of Psychology, University of Hamburg, Hamburg, Germany
STEPHAN JEFF RUSTENBACH
Affiliation:
Center for Internal Medicine and Dermatology, German Center of Competence in Health Services Research in Dermatology, University Clinics of Hamburg, Hamburg, Germany
*
†Correspondence and reprint requests to: Jörn Prohl, Department of Cognitive Rehabilitation, Neurological Rehabilitation Center Godeshöhe, Academic Teaching Hospital, University of Bonn, Waldstraße 2-10, 53117 Bonn, Germany. E-mail: joern.prohl@t-online.de
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Abstract

This prospective study evaluated the prognostic value of early neurobiochemical markers, neuron-specific enolase and astroglial protein S-100B, for long-term cognitive outcome after cardiac arrest. Six months after admission of a cohort of 80 consecutive patients, 26 survivors were able to undergo a neuropsychological test battery. Survivors showed low test performances in attention, learning/memory, and executive functioning. Neuropsychological bedside screening during the first month significantly differentiated between patients with and without long-term cognitive impairment. The neurobiochemical marker S-100B at day 3 after admission was found to predict significant proportions of variance in specific cognitive domains (learning/memory and executive functioning). The results indicate that early neuropsychological assessment might help identify patients who run at risk of long-term neuropsychological dysfunction. This study also suggests that especially the protein S-100B provides valuable information on long-term cognitive outcomes. To understand the exact relationship, results have to be replicated in larger trials. (JINS, 2009, 15, 344–353.)

Keywords

Hypoxic-ischemic encephalopathyPrognosesNeurobiochemical markersS-100BNeuron-specific enolaseNeuropsychological bedside screening
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 3 , May 2009 , pp. 344 - 353
Copyright
Copyright © The International Neuropsychological Society 2009

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