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Hippocampal volume and declarative memory function in combat-related PTSD

  • STEVEN H. WOODWARD (a1), DANNY G. KALOUPEK (a2) (a3), LAURA J. GRANDE (a4), WENDY K. STEGMAN (a5), CATHERINE J. KUTTER (a6), LORAINE LESKIN (a7), REBECCA PRESTEL (a2), MARIE SCHAER (a8) (a9), ALLAN L. REISS (a10) and STEPHAN ELIEZ (a8)...
Abstract
Abstract

The proposition that declarative memory deficits are systematically related to smaller hippocampal volume was tested in a relatively large sample (n = 95) of U.S. military veterans with and without combat-related posttraumatic stress disorder. This correlative analysis was extended by including multiple measures of verbal and visual declarative memory and multiple memory-relevant regional brain volumes that had been shown to exhibit main effects of PTSD in prior work. Small-to-moderate effects were observed on verbal declarative memory in line with a recent meta-analysis; nevertheless, little or no evidence of systematic linear covariation between memory measures and brain volumes was observed. (JINS, 2009, 15, 830–839.)

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Corresponding author
*Correspondence and reprint requests to: Steven H. Woodward, Ph.D., Dissemination and Training Division, National Center for PTSD, Mail Code 334 PTSD, VA Palo Alto HCS, 3801 Miranda Avenue, Palo Alto, CA 94304. E-mail: steve.woodward@va.gov
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