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A Précis of Recent Advances in the Neuropsychology of Mild Cognitive Impairment(s) in Parkinson's Disease and a Proposal of Preliminary Research Criteria

Published online by Cambridge University Press:  08 April 2011

Alexander I. Tröster
Alexander I. Tröster*
Affiliation:
Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina
*
Correspondence and reprint requests to: Alexander I. Tröster, Department of Neurology (CB 7025), University of North Carolina at Chapel Hill, 3128 Physicians’ Office Building, 170 Manning Drive, Chapel Hill, NC 27599-7025. E-mail: trostera@neurology.unc.edu
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Abstract

Cognitive changes of Parkinson's disease (PD) manifest earlier and are more heterogeneous than previously appreciated. Approximately one-third of patients have at least mild cognitive changes at PD diagnosis, and subtle changes might be appreciable among those at risk for PD. Executive dysfunction is the most common cognitive change, but other phenotypes exist. Pathobiologic and potential prognostic differences among cognitive phenotypes remain poorly understood. Progress in the neuropsychology, epidemiology and pathobiology of mild cognitive impairment (MCI) in PD is hampered by lack of diagnostic criteria. This study proposes preliminary research criteria for two categories of PD non-dementia cognitive impairment. (JINS, 2011, 17, 393–406)

Keywords

Lewy body diseaseDementiaMemory disordersExecutive functionAttentionBiological markers
Type
Short Reviews
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 3 , May 2011 , pp. 393 - 406
Copyright
Copyright © The International Neuropsychological Society 2011

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