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Schizotypal disorder and schizophrenia: A profile analysis of neuropsychological functioning in Japanese patients


This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporolimbic structures provide direction for further studies. (JINS, 2007, 13, 672–682.)

Corresponding author
Correspondence and reprint requests to: Dr. Mié Matsui, Department of Neuropsychology, Graduate School of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. E-mail:
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Addington, J. (2000). Cognitive functioning and negative symptoms in schizophrenia. In T. Sharma & P. Harvey (Eds.), Cognition in schizophrenia (pp. 193209). Oxford: Oxford University Press.
Amano, S. & Kondo, K. (2000). Nihongo-no Goitokusei (Lexical properties of Japanese) 2nd release, Vol. 7 frequency. NTT database series. Tokyo: Sanseido.
American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association Press.
Andreasen, N.C. (1983). The Scale for the Assessment of Negative Symptoms (SANS). Iowa: The University of Iowa.
Andreasen, N.C. (1984). The Scale for the Assessment of Positive Symptoms (SAPS). Iowa: The University of Iowa.
Andreasen, N.C., Flaum, M., & Arndt, S. (1992). The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Archives of General Psychiatry, 49, 615623.
Braff, D.L. (1981). Impaired speed of information processing in nonmedicated schizotypal patients. Schizophrenia Bulletin, 7, 499508.
Cadenhead, K.S., Geyer, M.A., & Braff, D.L. (1993). Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. American Journal of Psychiatry, 150, 18621867.
Cadenhead, K.S, Perry, W., Shafer, K., & Braff, D.L. (1999). Cognitive functions in schizotypal personality disorder. Schizophrenia Research, 37, 123132.
Censits, D.M., Ragland, J.D., Gur, R.C., & Gur, R.E. (1997). Neuropsychological evidence supporting a neurodevelopmental model of schizophrenia: A longitudinal study. Schizophrenia Research, 24, 289298.
Chapman, L.J. & Chapman, J.P. (1978). The measurement of differential deficit. Journal of Psychiatry Research, 14, 303311.
Cohen, J. (1988). Statistical power analysis for the behavioral science (2nd ed.). New York: Academic Press.
Dickey, C.C., McCarley, R.W., & Shenton, M.E. (2002). The brain in schizotypal personality disorder: A review of structural MRI and CT findings. Harvard Review of Psychiatry, 10, 115.
First, M.B., Gibbon, M., Spitzer, R.L., Williams, J.B.W., & Benjamin, L.S. (1997). Structured clinical interview for DSM-IV axis II personality disorders (SCID-II). Washington, DC: American Psychiatric Publishing.
First, M.B., Spitzer, R.L., Gibbon, M., & Williams, J.B.W. (1996). Structured clinical interview for DSM-IV axis I disorders (SCID-I). Washington, DC: American Psychiatric Publishing.
Gold, J.M., Randolph, C., Carpenter, C.J., Goldberg, T.E., & Weinberger, D.R. (1992). Forms of memory failure in schizophrenia. Journal of Abnormal Psychology, 101, 487494.
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., & Curtiss, G. (1993). Wisconsin Card Sorting Test. Manual. Revised and expanded. Odessa, TX: Psychological Assessment Resources.
Heinrichs, R.W. & Zakzanis, K.K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology, 12, 426445.
Inagaki, A. & Inada, T. (2006). Dose equivalence of psychotropic drugs: 2006-version. Rinsyou Seisihn Yakuri (Clinical Psychopharmachology), 9, 14431447 (in Japanese).
Kawasaki, Y., Suzuki, M., Nohara, S., Hagino, H., Takahashi, T., Matsui, M., Yamashita, I., Chitnis, X.A., McGuire, P.K., Seto, H., & Kurachi, M. (2004). Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. European Archives of Psychiatry and Clinical Neurosciences, 254, 406414.
Kolb, B. & Whishow, L.Q. (2003). Fundamentals of human neuropsychology. New York: Worth Publishers.
Kurachi, M. (2003). Pathogenesis of schizophrenia: Part II. Temporo-frontal two-step hypothesis. Psychiatry and Clinical Neurosciences, 57, 915.
Laurent, A., Duly, D., Murry, P., Foussard, N., Boccara, S., Mingat, F., Dalery, J., & d'Amato, T. (2001). WCST performance and schizotypal features in the first-degree relatives of patients with schizophrenia. Psychiatry Research, 104, 133144.
Lencz, T., Smith, C.W., McLaughlin, D., Auther, A., Nakayama, E., Hovey, L., & Cornblatt, B.A. (2006). Generalized and specific neurocognitive deficits in prodromal schizophrenia. Biological Psychiatry, 59, 863871.
Matsui, M., Sumiyoshi, T., Kato, K., Yoneyama, E., & Kurachi, M. (2004). Neuropsychological profile in patients with schizotypal personality disorder or schizophrenia. Psychological Reports, 94, 387397.
Matsui, M., Sumiyoshi, T., Niu, L., Kurokawa, K., & Kurachi, M. (2002). Minnesota Multiphasic Personality Inventory profile characteristics of schizotypal personality disorder. Psychiatry and Clinical Neurosciences, 56, 443452.
Matsui, M., Yuuki, H., Kato, K., & Kurachi, M. (2006). Impairment of memory organization in patients with schizophrenia or schizotypal disorder, Journal of the International Neuropsychological Society, 12, 750754.
Matsuoka, K., Kim, Y., Hiro, H., Miyamoto, Y., Fujita, K., Tanaka, K., Koyama, K., & Kazuki, N. (2002). Development of Japanese Adult Reading Test (JART). Seishin Igaku, 44, 503511 (in Japanese).
Mitropoulou, V., Harvey, P.D., Maldari, L.A., Moriarty, P.J., New, A.S., Silverman, J.M., & Siever, L.J. (2002). Neuropsychological performance in schizotypal personality disorder: Evidence regarding diagnostic specificity. Biological Psychiatry, 52, 11751182.
Mitropoulou, V., Harvey, P.D., Zegarelli, G., New, A.S., Silverman, J.M., & Siever, L.J. (2005). Neuropsychological performance in schizotypal personality disorder: Importance of working memory. American Journal of Psychiatry, 162, 18961903.
Nelson, H.E. (1976). A modified card sorting test sensitive to frontal lobe defects. Cortex, 12, 313324.
New Japanese MMPI Committee. (1993). Manual for the New Japanese Minnesota Multiphasic Personality Inventory. Kyoto: San-Kyo-Bo (in Japanese).
New Japanese MMPI Committee. (1997). Study of Standardization for the New Japanese MMPI. Kyoto: San-Kyo-Bo (in Japanese).
Nuechterlein, K.H., Barch, D.M., Gold, J.M., Goldberg, T.E., Green, M.F., & Heaton, R.K. (2004). Identification of separable cognitive factors in schizophrenia. Schizophrenia Research, 72, 2939.
Ogawa, T. (1972). Table of frequency in the recall of words belonging to 52 categories. Journal of the Literary Association of Kwansei Gakuin University, 22, 160 (in Japanese).
Overall, J.E. & Gorham, D.R. (1952). The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799812.
Raine, R. (2006). Schizotypal personality: Neurodevelopmental and psychosocial trajectories. Annual Review of Clinical Psychology, 2, 291326.
Reitan, R.M. (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271276.
Reitan, R.M. & Wolfson, D. (1985). The Halstead-Reitan Neuropsychological Test Battery. Tucson, AZ: Neuropsychology Press.
Roitman, S.E., Mitropoulou, V., Keefe, R.S., Silverman, J.M., Serby, M., Harvey, P.D., Reynolds, D.A., Mohs, R.C., & Siever, L.R. (2000). Visuospatial working memory in schizotypal personality disorder patients. Schizophrenia Research, 41, 447455.
Saykin, A.J., Gur, R.C., Gur, R.E., Mozley, P.D., Mozley, L.H., Resnick, S.M., Kester, B., & Stafiniak, P. (1991). Neuropsychological function in schizophrenia: Selective impairment in memory and learning. Archives of General Psychiatry, 48, 618624.
Saykin, A.J., Shtasel, D.J., Gur, R.E., Kester, D.B., Mozley, L.H., Stafiniak, P., & Gur, R.C. (1994). Neuropsychological deficits in neuroleptic naïve patients with first-episode schizophrenia. Archives of General Psychiatry, 51, 124131.
Shenton, M.E., Dickey, C.C., Frumin, M., & McCarley, R.W. (2001). A review of MRI findings in schizophrenia. Schizophrenia Research, 49, 152.
Shinagawa, F., Kobayashi, S., Fujita, K., & Maekawa, H. (1990). The Japanese version of the Wechsler Adult Intelligence Scaled-Revised. Tokyo: Nihon Bunka Kagakusya.
Siever, L.J. & Davis, K.L. (2004). The pathophysiology of schizophrenia disorders: Perspectives from the spectrum. American Journal of Psychiatry, 161, 398413.
Siever, L.J., Koenigsberg, H.W., Harvey, P., Mitropoulou, V., Laruelle, M., Abi-Dargham, A., Goodman, M., & Buchsbaum, M. (2002). Cognitive and brain function in schizotypal personality disorder. Schizophrenia Research, 54, 157167.
Spreen, O.S. & Strauss, E. (1998). A Compendium of Neuropsychological Tests. New York: Oxford University Press.
Sugishita, M. (2001). The Japanese version of the Wechsler Memory Scaled-Revised. Tokyo: Nihon Bunka Kagakusya.
Sullivan, E.V., Shear, P.K., Zipursky, R.B., Sagar, H.J., & Pfefferbaum, A. (1994). A deficit profile of executive, memory, and motor functions in schizophrenia. Biological Psychiatry, 36, 641653.
Sumiyoshi, C., Matsui, M., Sumiyoshi, T., Yamashita, I., Sumiyoshi, S., & Kurachi, M. (2001). Semantic structure in schizophrenia as assessed by the category fluency test: Effect of verbal intelligence and age of onset. Psychiatry Research, 105, 187199.
Sumiyoshi, C., Sumiyoshi, T., Matsui, M., Nohara, S., Yamashita, I., Kurachi, M., & Niwa, S. (2004). Effects of orthography on the verbal fluency performance in schizophrenia: Examination using Japanese patients. Schizophrenia Research, 69, 1522.
Suzuki, M., Zhou, S.Y., Takahashi, T., Hagino, H., Kawasaki, Y., Niu, L., Matsui, M., Seto, H., & Kurachi, M. (2005). Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis. Brain, 128, 21092122.
Takahashi, T., Suzuki, M., Zhou, S.Y., Tanino, R., Hagino, H., Kawasaki, Y., Matsui, M., Seto, H., & Kurachi, M. (2006). Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum. Schizophrenia Research, 83, 131143.
Trestman, R.L., Keefe, R.S., Mitropoulou, V., Harvey, P.D., deVegvar, M.L., Lees-Roitman, S., Davidson, M., Aronson, A., Silverman, J., & Siever, L.J. (1995). Cognitive function and biological correlates of cognitive performance in schizotypal personality disorder. Psychiatry Research, 59, 127136.
Voglmaier, M.M., Seidman, L.J., Niznikiewicz, M.A., Dickey, C.C., Shenton, M.E., & McCarley, R.W. (2005). A comparative profile analysis of neuropsychological function in men and women with schizotypal personality disorder. Schizophrenia Research, 74, 4349.
Voglmaier, M.M., Seidman, L.J., Salisbury, D., & McCarley, R.W. (1997). Neuropsychological dysfunction in schizotypal personality disorder: A profile analysis. Biological Psychiatry, 41, 530540.
World Health Organization. (1993). The ICD-10 Classification of Mental and Behavioral Disorders: Diagnostic criteria for research. World Health Organization: Geneva.
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Journal of the International Neuropsychological Society
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