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  • Journal of the International Neuropsychological Society, Volume 18, Issue 5
  • September 2012, pp. 834-844

The Frontal-Anatomic Specificity of Design Fluency Repetitions and Their Diagnostic Relevance for Behavioral Variant Frontotemporal Dementia

Abstract
Abstract

On tests of design fluency, an examinee draws as many different designs as possible in a specified time limit while avoiding repetition. The neuroanatomical substrates and diagnostic group differences of design fluency repetition errors and total correct scores were examined in 110 individuals diagnosed with dementia, 53 with mild cognitive impairment (MCI), and 37 neurologically healthy controls. The errors correlated significantly with volumes in the right and left orbitofrontal cortex (OFC), the right and left superior frontal gyrus, the right inferior frontal gyrus, and the right striatum, but did not correlate with volumes in any parietal or temporal lobe regions. Regression analyses indicated that the lateral OFC may be particularly crucial for preventing these errors, even after excluding patients with behavioral variant frontotemporal dementia (bvFTD) from the analysis. Total correct correlated more diffusely with volumes in the right and left frontal and parietal cortex, the right temporal cortex, and the right striatum and thalamus. Patients diagnosed with bvFTD made significantly more repetition errors than patients diagnosed with MCI, Alzheimer's disease, semantic dementia, progressive supranuclear palsy, or corticobasal syndrome. In contrast, total correct design scores did not differentiate the dementia patients. These results highlight the frontal-anatomic specificity of design fluency repetitions. In addition, the results indicate that the propensity to make these errors supports the diagnosis of bvFTD. (JINS, 2012, 18, 1–11)

Copyright
Corresponding author
Correspondence and reprint requests to: Katherine L. Possin, UCSF Memory and Aging Center, Box 1207, San Francisco, CA 94143-1207. E-mail: kpossin@memory.ucsf.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J.V. Baldo , A.P. Shimamura , D.C. Delis , J. Kramer , E. Kaplan (2001). Verbal and design fluency in patients with frontal lobe lesions. Journal of the International Neuropsychological Society, 7(5), 586596.

A. Bechara (2004). The role of emotion in decision-making: Evidence from neurological patients with orbitofrontal damage. Brain and Cognition, 55(1), 3040.

B.L. Brooks , L.E. Weaver , C.T. Scialfa (2006). Does impaired executive functioning differentially impact verbal memory measures in older adults with suspected dementia? Archives of Clinical Neuropsychology, 20(2), 230242.

C.L. Carey , S.P. Woods , J. Damon , C. Halabi , D. Dean , D.C. Delis , J.H. Kramer (2008). Discriminant validity and neuroanatomical correlates of rule monitoring in frontotemporal dementia and Alzheimer's disease. Neuropsychologia, 46(4), 10811087.

A.M. Dale , B. Fischl , M.I. Sereno (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage, 9(2), 179194.

R.S. Desikan , F. Segonne , B. Fischl , B.T. Quinn , B.C. Dickerson , D. Blacker , R.J. Kiliany (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage, 31(3), 968980.

M. D'Esposito (2007). From cognitive to neural models of working memory. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 362(1481), 761772.

C.I. Elfgren , J. Risberg (1998). Lateralized frontal blood flow increases during fluency tasks: Influence of cognitive strategy. Neuropsychologia, 36(6), 505512.

B. Fischl , A. Liu , A.M. Dale (2001). Automated manifold surgery: Constructing geometrically accurate and topologically correct models of the human cerebral cortex. IEEE Transactions on Medical Imaging, 20(1), 7080.

B. Fischl , D.H. Salat , E. Busa , M. Albert , M. Dieterich , C. Haselgrove , A.M. Dale (2002). Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron, 33(3), 341355.

N.S. Foldi , N. Helm-Estabrooks , J. Redfield , D.G. Nickel (2010). Perseveration in normal aging: A comparison of perseveration rates on design fluency and verbal generative tasks. Aging, Neuropsychology, and Cognition, 10(4), 268280.

M.F. Folstein , S.E. Folstein , P.R. McHugh (1975). “Mini-mental state” A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189198.

A.R. Giovagnoli , A. Erbetta , F. Reati , O. Bugiani (2008). Differential neuropsychological patterns of frontal variant frontotemporal dementia and Alzheimer's disease in a study of diagnostic concordance. Neuropsychologia, 46(5), 14951504.

E. Goldberg (1986). Varieties of perseveration: A comparison of two taxonomies. Journal of Clinical and Experimental Neuropsychology, 8(6), 710726.

M.L. Gorno-Tempini , A.E. Hillis , S. Weintraub , A. Kertesz , M. Mendez , S.F. Cappa , M. Grossman (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 10061014.

L.H. Heflin , V. Laluz , J.Y. Jang , R. Ketelle , B.L. Miller , J.H. Kramer (2011). Let's inhibit our excitement: The relationships between Stroop, behavioral disinhibition, and the frontal lobes. Neuropsychology, 25, 655665.

L. Heimer , G.W. Van Hoesen (2006). The limbic lobe and its output channels: Implications for emotional functions and adaptive behavior. Neuroscience and Biobehavioral Reviews, 30(2), 126147.

J.R. Hodges , K. Patterson , R. Ward , P. Garrard , T. Bak , R. Perry , C. Gregory (1999). The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: A comparative neuropsychological study. Neuropsychology, 13(1), 3140.

G. Hotz , N. Helm-Estabrooks (1995). Perseveration. Part II: A study of perseveration in closed-head injury. Brain Inj, 9(2), 161172.

A.D. Hutchinson , J.L. Mathias (2007). Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: A meta-analytic review. Journal of Neurology, Neurosurgery, and Psychiatry, 78(9), 917928.

C. Jenner , G. Reali , M. Puopolo , M.C. Silveri (2006). Can cognitive and behavioural disorders differentiate frontal variant-frontotemporal dementia from Alzheimer's disease at early stages? Behavioural Neurology, 17(2), 8995.

K.A. Josephs (2008). Frontotemporal dementia and related disorders: Deciphering the enigma. Annals of Neurology, 64(1), 414.

E. Kaplan (1988). A process approach to neuropsychological assessment. In Clinical neuropsychology and brain function: Research, measurement, and practice. Washington, DC: American Psychological Association.

J.H. Kramer , J. Jurik , S.J. Sha , K.P. Rankin , H.J. Rosen , J.K. Johnson , B.L. Miller (2003). Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease. Cognitive and Behavioral Neurology, 16(4), 211218.

M.L. Kringelbach , E.T. Rolls (2004). The functional neuroanatomy of the human orbitofrontal cortex: Evidence from neuroimaging and neuropsychology. Progress in Neurobiology, 72(5), 341372.

M. Lamar , K. Podell , T.G. Carew , B.S. Cloud , R. Resh , C. Kennedy , D.J. Libon (1997). Perseverative behavior in Alzheimer's disease and subcortical ischemic vascular dementia. Neuropsychology, 11(4), 523534.

S.E. Lee , G.D. Rabinovici , M.C. Mayo , S.M. Wilson , W.W. Seeley , S.J. Dearmond , B.L. Miller (2011). Clinicopathological correlations in corticobasal degeneration. Annals of Neurology, 70(2), 327340.

M.L. Levy , B.L. Miller , J.L. Cummings , L.A. Fairbanks , A. Craig (1996). Alzheimer disease and frontotemporal dementias. Behavioral distinctions. Archives of Neurology, 53(7), 687690.

D.J. Libon , S.X. Xie , P. Moore , J. Farmer , S. Antani , G. McCawley , M. Grossman (2007). Patterns of neuropsychological impairment in frontotemporal dementia. Neurology, 68(5), 369375.

I. Litvan , Y. Agid , D. Calne , G. Campbell , B. Dubois , R.C. Duvoisin , D.S. Zee (1996). Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP international workshop. Neurology, 47(1), 19.

X. Liu , D.K. Powell , H. Wang , B.T. Gold , C.R. Corbly , J.E. Joseph (2007). Functional dissociation in frontal and striatal areas for processing of positive and negative reward information. The Journal of Neuroscience, 27(17), 45874597.

A.R. Luria (1965). Two kinds of motor perseveration in massive injury of the frontal lobes. Brain, 88, 110.

F. Manes , B. Sahakian , L. Clark , R. Rogers , N. Antoun , M. Aitken , T. Robbins (2002). Decision-making processes following damage to the prefrontal cortex. Brain, 125(Pt 3), 624639.

G. McKhann , D. Drachman , M. Folstein , R. Katzman , D. Price , E.M. Stadlan (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34(7), 939944.

N.G. Muller , R.T. Knight (2006). The functional neuroanatomy of working memory: Contributions of human brain lesion studies. Neuroscience, 139(1), 5158.

D. Neary , J.S. Snowden , L. Gustafson , U. Passant , D. Stuss , S. Black , D.F. Benson (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51(6), 15461554.

E. Nyhus , F. Barcelo (2009). The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: A critical update. Brain and Cognition, 71(3), 437451.

J. Pa , A. Boxer , L.L. Chao , A. Gazzaley , K. Freeman , J. Kramer , J.K. Johnson (2009). Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Annals of Neurology, 65(4), 414423.

R.J. Perry , A. Graham , G. Williams , H. Rosen , S. Erzinclioglu , M. Weiner , J. Hodges (2006). Patterns of frontal lobe atrophy in frontotemporal dementia: A volumetric MRI study. Dementia and Geriatric Cognitive Disorders, 22(4), 278287.

J.N. Porter , P.F. Collins , R.L. Muetzel , K.O. Lim , M. Luciana (2011). Associations between cortical thickness and verbal fluency in childhood, adolescence, and young adulthood. Neuroimage, 55(4), 18651877.

K.L. Possin , J.V. Filoteo , S.C. Roesch , V. Zizak , L.M. Rilling , J.D. Davis (2005). Is a perseveration a perseveration? An evaluation of cognitive error types in patients with subcortical pathology. Journal of Clinical and Experimental Neuropsychology, 27(8), 953966.

K.P. Rankin , J.H. Kramer , B.L. Miller (2005). Patterns of cognitive and emotional empathy in frontotemporal lobar degeneration. Cognitive and Behavioral Neurology, 18(1), 2836.

K.P. Rankin , W. Santos-Modesitt , J.H. Kramer , D. Pavlic , V. Beckman , B.L. Miller (2008). Spontaneous social behaviors discriminate behavioral dementias from psychiatric disorders and other dementias. Journal of Clinical Psychiatry, 69(1), 6073.

K. Rascovsky , J.R. Hodges , C.M. Kipps , J.K. Johnson , W.W. Seeley , M.F. Mendez , B.L. Miller (2007). Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): Current limitations and future directions. Alzheimer Disease and Associated Disorders, 21(4), S14S18.

K. Rascovsky , D.P. Salmon , G.J. Ho , D. Galasko , G.M. Peavy , L.A. Hansen , L.J. Thal (2002). Cognitive profiles differ in autopsy-confirmed frontotemporal dementia and AD. Neurology, 58(12), 18011808.

T.W. Robbins (1996). Dissociating executive functions of the prefrontal cortex. Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences, 351(1346), 14631470; discussion 1470–1471.

E. Salmon , D. Perani , F. Collette , D. Feyers , E. Kalbe , V. Holthoff , K. Herholz (2008). A comparison of unawareness in frontotemporal dementia and Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 79(2), 176179.

J. Sandson , M.L. Albert (1984). Varieties of perseveration. Neuropsychologia, 22(6), 715732.

J.D. Schmahmann , D.N. Pandya (2008). Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems. Cortex, 44(8), 10371066.

W.W. Seeley , R. Crawford , K. Rascovsky , J.H. Kramer , M. Weiner , B.L. Miller , M.L. Gorno-Tempini (2008). Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. Archives of Neurology, 65(2), 249255.

F. Segonne , A.M. Dale , E. Busa , M. Glessner , D. Salat , H.K. Hahn , B. Fischl (2004). A hybrid approach to the skull stripping problem in MRI. Neuroimage, 22(3), 10601075.

J.C. Thompson , C.L. Stopford , J.S. Snowden , D. Neary (2005). Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 76(7), 920927.

I.V. Viskontas , K.L. Possin , B.L. Miller (2007). Symptoms of frontotemporal dementia provide insights into orbitofrontal cortex function and social behavior. Annals of the New York Academy of Sciences, 1121, 528545.

T.D. Wager , E.E. Smith (2003). Neuroimaging studies of working memory: A meta-analysis. Cognitive, Affective, and Behavioral Neuroscience, 3(4), 255274.

B. Winblad , K. Palmer , M. Kivipelto , V. Jelic , L. Fratiglioni , L.O. Wahlund , R.C. Petersen (2004). Mild cognitive impairment–beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256(3), 240246.

D. Wittenberg , K.L. Possin , K. Rascovsky , K.P. Rankin , B.L. Miller , J.H. Kramer (2008). The early neuropsychological and behavioral characteristics of frontotemporal dementia. Neuropsychology Review, 18(1), 91102.

J.D. Woolley , B.K. Khan , N.K. Murthy , B.L. Miller , K.P. Rankin (2011). The diagnostic challenge of psychiatric symptoms in neurodegenerative disease: Rates of and risk factors for prior psychiatric diagnosis in patients with early neurodegenerative disease. Journal of Clinical Psychiatry, 72(2), 126133.

E.H. Yeterian , D.N. Pandya (1991). Prefrontostriatal connections in relation to cortical architectonic organization in rhesus monkeys. The Journal of Comparative Neurology, 312(1), 4367.

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