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In situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) for peripheral nerve interfaces

Published online by Cambridge University Press:  08 August 2018

Jamie M. Murbach ,
Seth Currlin ,
Adrienne Widener ,
Yuxin Tong ,
Shrirang Chhatre ,
Vivek Subramanian ,
David C. Martin ,
Blake N. Johnson  and
Kevin J. Otto
Jamie M. Murbach
Affiliation:
Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA
Seth Currlin
Affiliation:
Department of Neuroscience, University of Florida, Gainesville, FL 32611, USA
Adrienne Widener
Affiliation:
Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA
Yuxin Tong
Affiliation:
Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA
Shrirang Chhatre
Affiliation:
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA
Vivek Subramanian
Affiliation:
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA
David C. Martin
Affiliation:
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA
Blake N. Johnson
Affiliation:
Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA
Kevin J. Otto*
Affiliation:
Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA Department of Neuroscience, University of Florida, Gainesville, FL 32611, USA J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
*
Address all correspondence to Kevin J. Otto at kevin.otto@bme.ufl.edu
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Abstract

The goal of this study was to perform in situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in peripheral nerves to create a soft, precisely located injectable conductive polymer electrode for bi-directional communication. Intraneural PEDOT polymerization was performed to target both outer and inner fascicles via custom fabricated 3D printed cuff electrodes and monomer injection strategies using a combination electrode-cannula system. Electrochemistry, histology, and laser light sheet microscopy revealed the presence of PEDOT at specified locations inside of peripheral nerve. This work demonstrates the potential for using in situ PEDOT electrodeposition as an injectable electrode for recording and stimulation of peripheral nerves.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 1043 - 1049
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Copyright
Copyright © Materials Research Society 2018 

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